Summary | |
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Symbol | FPR2 |
Name | formyl peptide receptor 2 |
Aliases | LXA4R; HM63; FMLPX; FPR2A; ALXR; FPRL1; formyl peptide receptor-like 1; FMLPXA; FMLP-R-I; FMLP-related recep ...... |
Chromosomal Location | 19q13.3-q13.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Domain |
PF00001 7 transmembrane receptor (rhodopsin family) |
Function |
Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4). |
Biological Process |
GO:0002429 immune response-activating cell surface receptor signaling pathway GO:0002430 complement receptor mediated signaling pathway GO:0002757 immune response-activating signal transduction GO:0002764 immune response-regulating signaling pathway GO:0002768 immune response-regulating cell surface receptor signaling pathway GO:0006874 cellular calcium ion homeostasis GO:0006875 cellular metal ion homeostasis GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway GO:0007204 positive regulation of cytosolic calcium ion concentration GO:0050900 leukocyte migration GO:0051480 regulation of cytosolic calcium ion concentration GO:0055074 calcium ion homeostasis GO:0060326 cell chemotaxis GO:0072503 cellular divalent inorganic cation homeostasis GO:0072507 divalent inorganic cation homeostasis |
Molecular Function |
GO:0001653 peptide receptor activity GO:0004875 complement receptor activity GO:0004982 N-formyl peptide receptor activity GO:0008528 G-protein coupled peptide receptor activity |
Cellular Component | - |
KEGG |
hsa04080 Neuroactive ligand-receptor interaction |
Reactome |
R-HSA-373076: Class A/1 (Rhodopsin-like receptors) R-HSA-444473: Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-418594: G alpha (i) signalling events R-HSA-416476: G alpha (q) signalling events R-HSA-388396: GPCR downstream signaling R-HSA-500792: GPCR ligand binding R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-6798695: Neutrophil degranulation R-HSA-375276: Peptide ligand-binding receptors R-HSA-162582: Signal Transduction R-HSA-372790: Signaling by GPCR |
Summary | |
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Symbol | FPR2 |
Name | formyl peptide receptor 2 |
Aliases | LXA4R; HM63; FMLPX; FPR2A; ALXR; FPRL1; formyl peptide receptor-like 1; FMLPXA; FMLP-R-I; FMLP-related recep ...... |
Chromosomal Location | 19q13.3-q13.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between FPR2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between FPR2 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | FPR2 |
Name | formyl peptide receptor 2 |
Aliases | LXA4R; HM63; FMLPX; FPR2A; ALXR; FPRL1; formyl peptide receptor-like 1; FMLPXA; FMLP-R-I; FMLP-related recep ...... |
Chromosomal Location | 19q13.3-q13.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of FPR2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | FPR2 |
Name | formyl peptide receptor 2 |
Aliases | LXA4R; HM63; FMLPX; FPR2A; ALXR; FPRL1; formyl peptide receptor-like 1; FMLPXA; FMLP-R-I; FMLP-related recep ...... |
Chromosomal Location | 19q13.3-q13.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of FPR2 in various data sets.
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Points in the above scatter plot represent the mutation difference of FPR2 in various data sets.
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Summary | |
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Symbol | FPR2 |
Name | formyl peptide receptor 2 |
Aliases | LXA4R; HM63; FMLPX; FPR2A; ALXR; FPRL1; formyl peptide receptor-like 1; FMLPXA; FMLP-R-I; FMLP-related recep ...... |
Chromosomal Location | 19q13.3-q13.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FPR2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | FPR2 |
Name | formyl peptide receptor 2 |
Aliases | LXA4R; HM63; FMLPX; FPR2A; ALXR; FPRL1; formyl peptide receptor-like 1; FMLPXA; FMLP-R-I; FMLP-related recep ...... |
Chromosomal Location | 19q13.3-q13.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FPR2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FPR2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | FPR2 |
Name | formyl peptide receptor 2 |
Aliases | LXA4R; HM63; FMLPX; FPR2A; ALXR; FPRL1; formyl peptide receptor-like 1; FMLPXA; FMLP-R-I; FMLP-related recep ...... |
Chromosomal Location | 19q13.3-q13.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FPR2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | FPR2 |
Name | formyl peptide receptor 2 |
Aliases | LXA4R; HM63; FMLPX; FPR2A; ALXR; FPRL1; formyl peptide receptor-like 1; FMLPXA; FMLP-R-I; FMLP-related recep ...... |
Chromosomal Location | 19q13.3-q13.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of FPR2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | FPR2 |
Name | formyl peptide receptor 2 |
Aliases | LXA4R; HM63; FMLPX; FPR2A; ALXR; FPRL1; formyl peptide receptor-like 1; FMLPXA; FMLP-R-I; FMLP-related recep ...... |
Chromosomal Location | 19q13.3-q13.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between FPR2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | FPR2 |
Name | formyl peptide receptor 2 |
Aliases | LXA4R; HM63; FMLPX; FPR2A; ALXR; FPRL1; formyl peptide receptor-like 1; FMLPXA; FMLP-R-I; FMLP-related recep ...... |
Chromosomal Location | 19q13.3-q13.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting FPR2 collected from DrugBank database. |
There is no record. |