Summary | |
---|---|
Symbol | FSCN1 |
Name | fascin actin-bundling protein 1 |
Aliases | FLJ38511; Singed, drosophila, homolog-like; actin bundling protein; SNL; singed (Drosophila)-like (sea urchi ...... |
Chromosomal Location | 7p22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm, cytosol Cytoplasm, cytoskeleton Cell projection, filopodium Cell projection, invadopodium Cell projection, microvillus Cell junction Note=In glioma cells, partially colocalizes with F-actin stress fibers in the cytosol (PubMed:21706053). Colocalized with RUFY3 and F-actin at filipodia of the axonal growth cone. Colocalized with DBN1 and F-actin at the transitional domain of the axonal growth cone (By similarity). |
Domain |
PF06268 Fascin domain |
Function |
Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration. |
Biological Process |
GO:0007015 actin filament organization GO:0007043 cell-cell junction assembly GO:0007163 establishment or maintenance of cell polarity GO:0010591 regulation of lamellipodium assembly GO:0010592 positive regulation of lamellipodium assembly GO:0010715 regulation of extracellular matrix disassembly GO:0022617 extracellular matrix disassembly GO:0030010 establishment of cell polarity GO:0030031 cell projection assembly GO:0030032 lamellipodium assembly GO:0030033 microvillus assembly GO:0030035 microspike assembly GO:0030198 extracellular matrix organization GO:0031334 positive regulation of protein complex assembly GO:0031346 positive regulation of cell projection organization GO:0032528 microvillus organization GO:0032530 regulation of microvillus organization GO:0032534 regulation of microvillus assembly GO:0032956 regulation of actin cytoskeleton organization GO:0032970 regulation of actin filament-based process GO:0034329 cell junction assembly GO:0034330 cell junction organization GO:0035088 establishment or maintenance of apical/basal cell polarity GO:0035089 establishment of apical/basal cell polarity GO:0043062 extracellular structure organization GO:0043254 regulation of protein complex assembly GO:0044089 positive regulation of cellular component biogenesis GO:0045216 cell-cell junction organization GO:0046847 filopodium assembly GO:0051017 actin filament bundle assembly GO:0051489 regulation of filopodium assembly GO:0051491 positive regulation of filopodium assembly GO:0051493 regulation of cytoskeleton organization GO:0060491 regulation of cell projection assembly GO:0061162 establishment of monopolar cell polarity GO:0061245 establishment or maintenance of bipolar cell polarity GO:0061339 establishment or maintenance of monopolar cell polarity GO:0061572 actin filament bundle organization GO:0071800 podosome assembly GO:0071801 regulation of podosome assembly GO:0071803 positive regulation of podosome assembly GO:0090091 positive regulation of extracellular matrix disassembly GO:0097581 lamellipodium organization GO:1902115 regulation of organelle assembly GO:1902117 positive regulation of organelle assembly GO:1902743 regulation of lamellipodium organization GO:1902745 positive regulation of lamellipodium organization GO:1903053 regulation of extracellular matrix organization GO:1903055 positive regulation of extracellular matrix organization |
Molecular Function |
GO:0003779 actin binding GO:0008144 drug binding GO:0030674 protein binding, bridging GO:0045296 cadherin binding GO:0050839 cell adhesion molecule binding GO:0051015 actin filament binding GO:0060090 binding, bridging GO:0098631 protein binding involved in cell adhesion GO:0098632 protein binding involved in cell-cell adhesion GO:0098641 cadherin binding involved in cell-cell adhesion |
Cellular Component |
GO:0001725 stress fiber GO:0001726 ruffle GO:0002102 podosome GO:0005884 actin filament GO:0005902 microvillus GO:0005913 cell-cell adherens junction GO:0015629 actin cytoskeleton GO:0030027 lamellipodium GO:0030175 filopodium GO:0030426 growth cone GO:0030427 site of polarized growth GO:0031252 cell leading edge GO:0031253 cell projection membrane GO:0031941 filamentous actin GO:0032432 actin filament bundle GO:0042641 actomyosin GO:0043209 myelin sheath GO:0044393 microspike GO:0071437 invadopodium GO:0097517 contractile actin filament bundle GO:0098858 actin-based cell projection |
KEGG | - |
Reactome |
R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-168256: Immune System R-HSA-6785807: Interleukin-4 and 13 signaling R-HSA-449147: Signaling by Interleukins |
Summary | |
---|---|
Symbol | FSCN1 |
Name | fascin actin-bundling protein 1 |
Aliases | FLJ38511; Singed, drosophila, homolog-like; actin bundling protein; SNL; singed (Drosophila)-like (sea urchi ...... |
Chromosomal Location | 7p22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between FSCN1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | FSCN1 |
Name | fascin actin-bundling protein 1 |
Aliases | FLJ38511; Singed, drosophila, homolog-like; actin bundling protein; SNL; singed (Drosophila)-like (sea urchi ...... |
Chromosomal Location | 7p22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of FSCN1 in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | FSCN1 |
Name | fascin actin-bundling protein 1 |
Aliases | FLJ38511; Singed, drosophila, homolog-like; actin bundling protein; SNL; singed (Drosophila)-like (sea urchi ...... |
Chromosomal Location | 7p22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of FSCN1 in various data sets.
|
Points in the above scatter plot represent the mutation difference of FSCN1 in various data sets.
|
Summary | |
---|---|
Symbol | FSCN1 |
Name | fascin actin-bundling protein 1 |
Aliases | FLJ38511; Singed, drosophila, homolog-like; actin bundling protein; SNL; singed (Drosophila)-like (sea urchi ...... |
Chromosomal Location | 7p22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FSCN1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | FSCN1 |
Name | fascin actin-bundling protein 1 |
Aliases | FLJ38511; Singed, drosophila, homolog-like; actin bundling protein; SNL; singed (Drosophila)-like (sea urchi ...... |
Chromosomal Location | 7p22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FSCN1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FSCN1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | FSCN1 |
Name | fascin actin-bundling protein 1 |
Aliases | FLJ38511; Singed, drosophila, homolog-like; actin bundling protein; SNL; singed (Drosophila)-like (sea urchi ...... |
Chromosomal Location | 7p22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FSCN1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | FSCN1 |
Name | fascin actin-bundling protein 1 |
Aliases | FLJ38511; Singed, drosophila, homolog-like; actin bundling protein; SNL; singed (Drosophila)-like (sea urchi ...... |
Chromosomal Location | 7p22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of FSCN1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | FSCN1 |
Name | fascin actin-bundling protein 1 |
Aliases | FLJ38511; Singed, drosophila, homolog-like; actin bundling protein; SNL; singed (Drosophila)-like (sea urchi ...... |
Chromosomal Location | 7p22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between FSCN1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | FSCN1 |
Name | fascin actin-bundling protein 1 |
Aliases | FLJ38511; Singed, drosophila, homolog-like; actin bundling protein; SNL; singed (Drosophila)-like (sea urchi ...... |
Chromosomal Location | 7p22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting FSCN1 collected from DrugBank database. |
There is no record. |