Summary | |
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Symbol | FSHR |
Name | follicle stimulating hormone receptor |
Aliases | FSHRO; LGR1; ODG1; FSHR1O; FSH receptor; follitropin receptor; FSH-R; Follicle-stimulating hormone receptor |
Chromosomal Location | 2p21-p16 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Multi-pass membrane protein |
Domain |
PF00001 7 transmembrane receptor (rhodopsin family) PF12369 Gonadotropin hormone receptor transmembrane region PF13306 Leucine rich repeats (6 copies) PF01462 Leucine rich repeat N-terminal domain |
Function |
Receptor for follicle-stimulating hormone or follitropin (PubMed:11847099, PubMed:24058690). The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:11847099). Induces cAMP production through the activation of PI3K-AKT and SRC-ERK1/2 signaling pathways (PubMed:24058690). |
Biological Process |
GO:0001541 ovarian follicle development GO:0001545 primary ovarian follicle growth GO:0002521 leukocyte differentiation GO:0002573 myeloid leukocyte differentiation GO:0002761 regulation of myeloid leukocyte differentiation GO:0006140 regulation of nucleotide metabolic process GO:0006164 purine nucleotide biosynthetic process GO:0006171 cAMP biosynthetic process GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007190 activation of adenylate cyclase activity GO:0007283 spermatogenesis GO:0007292 female gamete generation GO:0007548 sex differentiation GO:0008406 gonad development GO:0008584 male gonad development GO:0008585 female gonad development GO:0009150 purine ribonucleotide metabolic process GO:0009152 purine ribonucleotide biosynthetic process GO:0009165 nucleotide biosynthetic process GO:0009187 cyclic nucleotide metabolic process GO:0009190 cyclic nucleotide biosynthetic process GO:0009260 ribonucleotide biosynthetic process GO:0009755 hormone-mediated signaling pathway GO:0010737 protein kinase A signaling GO:0010738 regulation of protein kinase A signaling GO:0014065 phosphatidylinositol 3-kinase signaling GO:0014066 regulation of phosphatidylinositol 3-kinase signaling GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling GO:0022602 ovulation cycle process GO:0030099 myeloid cell differentiation GO:0030316 osteoclast differentiation GO:0030799 regulation of cyclic nucleotide metabolic process GO:0030801 positive regulation of cyclic nucleotide metabolic process GO:0030802 regulation of cyclic nucleotide biosynthetic process GO:0030804 positive regulation of cyclic nucleotide biosynthetic process GO:0030808 regulation of nucleotide biosynthetic process GO:0030810 positive regulation of nucleotide biosynthetic process GO:0030814 regulation of cAMP metabolic process GO:0030816 positive regulation of cAMP metabolic process GO:0030817 regulation of cAMP biosynthetic process GO:0030819 positive regulation of cAMP biosynthetic process GO:0031279 regulation of cyclase activity GO:0031281 positive regulation of cyclase activity GO:0042698 ovulation cycle GO:0042699 follicle-stimulating hormone signaling pathway GO:0043410 positive regulation of MAPK cascade GO:0045137 development of primary sexual characteristics GO:0045637 regulation of myeloid cell differentiation GO:0045670 regulation of osteoclast differentiation GO:0045761 regulation of adenylate cyclase activity GO:0045762 positive regulation of adenylate cyclase activity GO:0045981 positive regulation of nucleotide metabolic process GO:0046058 cAMP metabolic process GO:0046390 ribose phosphate biosynthetic process GO:0046545 development of primary female sexual characteristics GO:0046546 development of primary male sexual characteristics GO:0046660 female sex differentiation GO:0046661 male sex differentiation GO:0048015 phosphatidylinositol-mediated signaling GO:0048017 inositol lipid-mediated signaling GO:0048232 male gamete generation GO:0048511 rhythmic process GO:0048608 reproductive structure development GO:0051339 regulation of lyase activity GO:0051349 positive regulation of lyase activity GO:0052652 cyclic purine nucleotide metabolic process GO:0061458 reproductive system development GO:0070371 ERK1 and ERK2 cascade GO:0070372 regulation of ERK1 and ERK2 cascade GO:0070374 positive regulation of ERK1 and ERK2 cascade GO:0072522 purine-containing compound biosynthetic process GO:1900371 regulation of purine nucleotide biosynthetic process GO:1900373 positive regulation of purine nucleotide biosynthetic process GO:1900542 regulation of purine nucleotide metabolic process GO:1900544 positive regulation of purine nucleotide metabolic process GO:1901293 nucleoside phosphate biosynthetic process GO:1902105 regulation of leukocyte differentiation GO:1903706 regulation of hemopoiesis |
Molecular Function |
GO:0001653 peptide receptor activity GO:0004963 follicle-stimulating hormone receptor activity GO:0008528 G-protein coupled peptide receptor activity GO:0016500 protein-hormone receptor activity |
Cellular Component | - |
KEGG |
hsa04024 cAMP signaling pathway hsa04080 Neuroactive ligand-receptor interaction hsa04913 Ovarian steroidogenesis |
Reactome |
R-HSA-373076: Class A/1 (Rhodopsin-like receptors) R-HSA-418555: G alpha (s) signalling events R-HSA-388396: GPCR downstream signaling R-HSA-500792: GPCR ligand binding R-HSA-375281: Hormone ligand-binding receptors R-HSA-162582: Signal Transduction R-HSA-372790: Signaling by GPCR |
Summary | |
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Symbol | FSHR |
Name | follicle stimulating hormone receptor |
Aliases | FSHRO; LGR1; ODG1; FSHR1O; FSH receptor; follitropin receptor; FSH-R; Follicle-stimulating hormone receptor |
Chromosomal Location | 2p21-p16 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between FSHR and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between FSHR and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | FSHR |
Name | follicle stimulating hormone receptor |
Aliases | FSHRO; LGR1; ODG1; FSHR1O; FSH receptor; follitropin receptor; FSH-R; Follicle-stimulating hormone receptor |
Chromosomal Location | 2p21-p16 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of FSHR in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | FSHR |
Name | follicle stimulating hormone receptor |
Aliases | FSHRO; LGR1; ODG1; FSHR1O; FSH receptor; follitropin receptor; FSH-R; Follicle-stimulating hormone receptor |
Chromosomal Location | 2p21-p16 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of FSHR in various data sets.
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Points in the above scatter plot represent the mutation difference of FSHR in various data sets.
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Summary | |
---|---|
Symbol | FSHR |
Name | follicle stimulating hormone receptor |
Aliases | FSHRO; LGR1; ODG1; FSHR1O; FSH receptor; follitropin receptor; FSH-R; Follicle-stimulating hormone receptor |
Chromosomal Location | 2p21-p16 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FSHR. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | FSHR |
Name | follicle stimulating hormone receptor |
Aliases | FSHRO; LGR1; ODG1; FSHR1O; FSH receptor; follitropin receptor; FSH-R; Follicle-stimulating hormone receptor |
Chromosomal Location | 2p21-p16 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FSHR. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FSHR. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | FSHR |
Name | follicle stimulating hormone receptor |
Aliases | FSHRO; LGR1; ODG1; FSHR1O; FSH receptor; follitropin receptor; FSH-R; Follicle-stimulating hormone receptor |
Chromosomal Location | 2p21-p16 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FSHR. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | FSHR |
Name | follicle stimulating hormone receptor |
Aliases | FSHRO; LGR1; ODG1; FSHR1O; FSH receptor; follitropin receptor; FSH-R; Follicle-stimulating hormone receptor |
Chromosomal Location | 2p21-p16 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of FSHR expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | FSHR |
Name | follicle stimulating hormone receptor |
Aliases | FSHRO; LGR1; ODG1; FSHR1O; FSH receptor; follitropin receptor; FSH-R; Follicle-stimulating hormone receptor |
Chromosomal Location | 2p21-p16 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between FSHR and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | FSHR |
Name | follicle stimulating hormone receptor |
Aliases | FSHRO; LGR1; ODG1; FSHR1O; FSH receptor; follitropin receptor; FSH-R; Follicle-stimulating hormone receptor |
Chromosomal Location | 2p21-p16 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting FSHR collected from DrugBank database. |
Details on drugs targeting FSHR.
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