Summary | |
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Symbol | FSTL4 |
Name | follistatin-like 4 |
Aliases | KIAA1061; follistatin-like protein 4; Follistatin-related protein 4 |
Chromosomal Location | 5q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted |
Domain |
PF07648 Kazal-type serine protease inhibitor domain |
Function |
- |
Biological Process |
GO:0001558 regulation of cell growth GO:0007409 axonogenesis GO:0008361 regulation of cell size GO:0010721 negative regulation of cell development GO:0010769 regulation of cell morphogenesis involved in differentiation GO:0010771 negative regulation of cell morphogenesis involved in differentiation GO:0010975 regulation of neuron projection development GO:0010977 negative regulation of neuron projection development GO:0016049 cell growth GO:0016358 dendrite development GO:0022604 regulation of cell morphogenesis GO:0030308 negative regulation of cell growth GO:0031345 negative regulation of cell projection organization GO:0031547 brain-derived neurotrophic factor receptor signaling pathway GO:0031548 regulation of brain-derived neurotrophic factor receptor signaling pathway GO:0031549 negative regulation of brain-derived neurotrophic factor receptor signaling pathway GO:0032535 regulation of cellular component size GO:0045665 negative regulation of neuron differentiation GO:0045926 negative regulation of growth GO:0048588 developmental cell growth GO:0048638 regulation of developmental growth GO:0048640 negative regulation of developmental growth GO:0048667 cell morphogenesis involved in neuron differentiation GO:0048668 collateral sprouting GO:0048670 regulation of collateral sprouting GO:0048671 negative regulation of collateral sprouting GO:0050768 negative regulation of neurogenesis GO:0050770 regulation of axonogenesis GO:0050771 negative regulation of axonogenesis GO:0050773 regulation of dendrite development GO:0051961 negative regulation of nervous system development GO:0060560 developmental growth involved in morphogenesis GO:0060996 dendritic spine development GO:0060998 regulation of dendritic spine development GO:0061000 negative regulation of dendritic spine development GO:0061387 regulation of extent of cell growth GO:0061564 axon development GO:0090066 regulation of anatomical structure size GO:2000171 negative regulation of dendrite development |
Molecular Function |
GO:0019838 growth factor binding GO:0043121 neurotrophin binding GO:0048403 brain-derived neurotrophic factor binding |
Cellular Component |
GO:0030141 secretory granule GO:0099503 secretory vesicle |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | FSTL4 |
Name | follistatin-like 4 |
Aliases | KIAA1061; follistatin-like protein 4; Follistatin-related protein 4 |
Chromosomal Location | 5q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between FSTL4 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | FSTL4 |
Name | follistatin-like 4 |
Aliases | KIAA1061; follistatin-like protein 4; Follistatin-related protein 4 |
Chromosomal Location | 5q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of FSTL4 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | FSTL4 |
Name | follistatin-like 4 |
Aliases | KIAA1061; follistatin-like protein 4; Follistatin-related protein 4 |
Chromosomal Location | 5q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of FSTL4 in various data sets.
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Points in the above scatter plot represent the mutation difference of FSTL4 in various data sets.
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Summary | |
---|---|
Symbol | FSTL4 |
Name | follistatin-like 4 |
Aliases | KIAA1061; follistatin-like protein 4; Follistatin-related protein 4 |
Chromosomal Location | 5q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FSTL4. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | FSTL4 |
Name | follistatin-like 4 |
Aliases | KIAA1061; follistatin-like protein 4; Follistatin-related protein 4 |
Chromosomal Location | 5q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FSTL4. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FSTL4. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | FSTL4 |
Name | follistatin-like 4 |
Aliases | KIAA1061; follistatin-like protein 4; Follistatin-related protein 4 |
Chromosomal Location | 5q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FSTL4. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | FSTL4 |
Name | follistatin-like 4 |
Aliases | KIAA1061; follistatin-like protein 4; Follistatin-related protein 4 |
Chromosomal Location | 5q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of FSTL4 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | FSTL4 |
Name | follistatin-like 4 |
Aliases | KIAA1061; follistatin-like protein 4; Follistatin-related protein 4 |
Chromosomal Location | 5q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between FSTL4 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |