Summary | |
---|---|
Symbol | FTL |
Name | ferritin, light polypeptide |
Aliases | MGC71996; ferritin light polypeptide-like 3; L apoferritin; ferritin L subunit; ferritin light chain; ferrit ...... |
Chromosomal Location | 19q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | - |
Domain |
PF00210 Ferritin-like domain |
Function |
Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). |
Biological Process |
GO:0000041 transition metal ion transport GO:0006826 iron ion transport GO:0006875 cellular metal ion homeostasis GO:0006879 cellular iron ion homeostasis GO:0006880 intracellular sequestering of iron ion GO:0046916 cellular transition metal ion homeostasis GO:0051235 maintenance of location GO:0051238 sequestering of metal ion GO:0051651 maintenance of location in cell GO:0055072 iron ion homeostasis GO:0055076 transition metal ion homeostasis GO:0097577 sequestering of iron ion |
Molecular Function |
GO:0005506 iron ion binding GO:0008199 ferric iron binding |
Cellular Component |
GO:0005767 secondary lysosome GO:0005776 autophagosome GO:0008043 intracellular ferritin complex GO:0044754 autolysosome GO:0070288 ferritin complex |
KEGG |
hsa04978 Mineral absorption |
Reactome |
R-HSA-2173782: Binding and Uptake of Ligands by Scavenger Receptors R-HSA-421837: Clathrin derived vesicle budding R-HSA-432722: Golgi Associated Vesicle Biogenesis R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-917937: Iron uptake and transport R-HSA-199991: Membrane Trafficking R-HSA-6798695: Neutrophil degranulation R-HSA-3000480: Scavenging by Class A Receptors R-HSA-382551: Transmembrane transport of small molecules R-HSA-5653656: Vesicle-mediated transport R-HSA-199992: trans-Golgi Network Vesicle Budding |
Summary | |
---|---|
Symbol | FTL |
Name | ferritin, light polypeptide |
Aliases | MGC71996; ferritin light polypeptide-like 3; L apoferritin; ferritin L subunit; ferritin light chain; ferrit ...... |
Chromosomal Location | 19q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between FTL and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between FTL and anti-tumor immunity in human cancer.
|
Summary | |
---|---|
Symbol | FTL |
Name | ferritin, light polypeptide |
Aliases | MGC71996; ferritin light polypeptide-like 3; L apoferritin; ferritin L subunit; ferritin light chain; ferrit ...... |
Chromosomal Location | 19q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of FTL in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | FTL |
Name | ferritin, light polypeptide |
Aliases | MGC71996; ferritin light polypeptide-like 3; L apoferritin; ferritin L subunit; ferritin light chain; ferrit ...... |
Chromosomal Location | 19q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of FTL in various data sets.
|
Points in the above scatter plot represent the mutation difference of FTL in various data sets.
|
Summary | |
---|---|
Symbol | FTL |
Name | ferritin, light polypeptide |
Aliases | MGC71996; ferritin light polypeptide-like 3; L apoferritin; ferritin L subunit; ferritin light chain; ferrit ...... |
Chromosomal Location | 19q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FTL. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | FTL |
Name | ferritin, light polypeptide |
Aliases | MGC71996; ferritin light polypeptide-like 3; L apoferritin; ferritin L subunit; ferritin light chain; ferrit ...... |
Chromosomal Location | 19q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FTL. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FTL. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | FTL |
Name | ferritin, light polypeptide |
Aliases | MGC71996; ferritin light polypeptide-like 3; L apoferritin; ferritin L subunit; ferritin light chain; ferrit ...... |
Chromosomal Location | 19q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FTL. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | FTL |
Name | ferritin, light polypeptide |
Aliases | MGC71996; ferritin light polypeptide-like 3; L apoferritin; ferritin L subunit; ferritin light chain; ferrit ...... |
Chromosomal Location | 19q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of FTL expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | FTL |
Name | ferritin, light polypeptide |
Aliases | MGC71996; ferritin light polypeptide-like 3; L apoferritin; ferritin L subunit; ferritin light chain; ferrit ...... |
Chromosomal Location | 19q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between FTL and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | FTL |
Name | ferritin, light polypeptide |
Aliases | MGC71996; ferritin light polypeptide-like 3; L apoferritin; ferritin L subunit; ferritin light chain; ferrit ...... |
Chromosomal Location | 19q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting FTL collected from DrugBank database. |
Details on drugs targeting FTL.
|