Browse FURIN

Summary
SymbolFURIN
Namefurin (paired basic amino acid cleaving enzyme)
Aliases PCSK3; FUR; PACE; paired basic amino acid cleaving enzyme (furin, membrane associated receptor protein); FES ......
Chromosomal Location15q26.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Golgi apparatus, trans-Golgi network membrane Single-pass type I membrane protein Cell membrane Single-pass type I membrane protein Secreted Endosome membrane Single-pass type I membrane protein Note=Shuttles between the trans-Golgi network and the cell surface (PubMed:9412467, PubMed:11799113). Propeptide cleavage is a prerequisite for exit of furin molecules out of the endoplasmic reticulum (ER). A second cleavage within the propeptide occurs in the trans Golgi network (TGN), followed by the release of the propeptide and the activation of furin (PubMed:11799113).
Domain PF01483 Proprotein convertase P-domain
PF00082 Subtilase family
PF16470 Peptidase S8 pro-domain
Function

Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif. ; FUNCTION: (Microbial infection) Probably cleaves and activates anthrax and diphtheria toxins.; FUNCTION: (Microbial infection) Required for H7N1 and H5N1 influenza virus infection probably by cleaving hemagglutinin.

> Gene Ontology
 
Biological Process GO:0001818 negative regulation of cytokine production
GO:0006465 signal peptide processing
GO:0006509 membrane protein ectodomain proteolysis
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0009894 regulation of catabolic process
GO:0009895 negative regulation of catabolic process
GO:0009896 positive regulation of catabolic process
GO:0010466 negative regulation of peptidase activity
GO:0010817 regulation of hormone levels
GO:0010869 regulation of receptor biosynthetic process
GO:0010951 negative regulation of endopeptidase activity
GO:0016485 protein processing
GO:0016486 peptide hormone processing
GO:0019058 viral life cycle
GO:0019080 viral gene expression
GO:0019082 viral protein processing
GO:0022617 extracellular matrix disassembly
GO:0030198 extracellular matrix organization
GO:0030574 collagen catabolic process
GO:0031329 regulation of cellular catabolic process
GO:0031330 negative regulation of cellular catabolic process
GO:0031331 positive regulation of cellular catabolic process
GO:0032455 nerve growth factor processing
GO:0032799 low-density lipoprotein receptor particle metabolic process
GO:0032800 receptor biosynthetic process
GO:0032801 receptor catabolic process
GO:0032802 low-density lipoprotein particle receptor catabolic process
GO:0032803 regulation of low-density lipoprotein particle receptor catabolic process
GO:0032804 negative regulation of low-density lipoprotein particle receptor catabolic process
GO:0032898 neurotrophin production
GO:0032902 nerve growth factor production
GO:0032905 transforming growth factor beta1 production
GO:0032908 regulation of transforming growth factor beta1 production
GO:0032911 negative regulation of transforming growth factor beta1 production
GO:0032963 collagen metabolic process
GO:0033619 membrane protein proteolysis
GO:0042176 regulation of protein catabolic process
GO:0042177 negative regulation of protein catabolic process
GO:0042445 hormone metabolic process
GO:0043062 extracellular structure organization
GO:0043112 receptor metabolic process
GO:0044033 multi-organism metabolic process
GO:0044236 multicellular organism metabolic process
GO:0044243 multicellular organism catabolic process
GO:0044259 multicellular organismal macromolecule metabolic process
GO:0045713 low-density lipoprotein particle receptor biosynthetic process
GO:0045714 regulation of low-density lipoprotein particle receptor biosynthetic process
GO:0045732 positive regulation of protein catabolic process
GO:0045861 negative regulation of proteolysis
GO:0045862 positive regulation of proteolysis
GO:0051043 regulation of membrane protein ectodomain proteolysis
GO:0051044 positive regulation of membrane protein ectodomain proteolysis
GO:0051346 negative regulation of hydrolase activity
GO:0051604 protein maturation
GO:0052547 regulation of peptidase activity
GO:0052548 regulation of endopeptidase activity
GO:0071559 response to transforming growth factor beta
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0071604 transforming growth factor beta production
GO:0071634 regulation of transforming growth factor beta production
GO:0071635 negative regulation of transforming growth factor beta production
GO:1903362 regulation of cellular protein catabolic process
GO:1903363 negative regulation of cellular protein catabolic process
GO:2000644 regulation of receptor catabolic process
GO:2000645 negative regulation of receptor catabolic process
Molecular Function GO:0002020 protease binding
GO:0004175 endopeptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0004857 enzyme inhibitor activity
GO:0004866 endopeptidase inhibitor activity
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0008236 serine-type peptidase activity
GO:0017171 serine hydrolase activity
GO:0019838 growth factor binding
GO:0030414 peptidase inhibitor activity
GO:0033218 amide binding
GO:0042277 peptide binding
GO:0043121 neurotrophin binding
GO:0048406 nerve growth factor binding
GO:0061134 peptidase regulator activity
GO:0061135 endopeptidase regulator activity
Cellular Component GO:0005796 Golgi lumen
GO:0005798 Golgi-associated vesicle
GO:0005802 trans-Golgi network
GO:0030133 transport vesicle
GO:0030135 coated vesicle
GO:0030136 clathrin-coated vesicle
GO:0030140 trans-Golgi network transport vesicle
GO:0031984 organelle subcompartment
GO:0045121 membrane raft
GO:0098589 membrane region
GO:0098791 Golgi subcompartment
GO:0098857 membrane microdomain
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-1592389: Activation of Matrix Metalloproteinases
R-HSA-977225: Amyloid fiber formation
R-HSA-175474: Assembly Of The HIV Virion
R-HSA-174800: Chylomicron-mediated lipid transport
R-HSA-1442490: Collagen degradation
R-HSA-1474228: Degradation of the extracellular matrix
R-HSA-1266738: Developmental Biology
R-HSA-1643685: Disease
R-HSA-1566948: Elastic fibre formation
R-HSA-1474244: Extracellular matrix organization
R-HSA-6809371: Formation of the cornified envelope
R-HSA-163841: Gamma carboxylation, hypusine formation and arylsulfatase activation
R-HSA-159854: Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
R-HSA-162906: HIV Infection
R-HSA-162587: HIV Life Cycle
R-HSA-5663205: Infectious disease
R-HSA-6805567: Keratinization
R-HSA-162599: Late Phase of HIV Life Cycle
R-HSA-73923: Lipid digestion, mobilization, and transport
R-HSA-174824: Lipoprotein metabolism
R-HSA-1430728: Metabolism
R-HSA-556833: Metabolism of lipids and lipoproteins
R-HSA-392499: Metabolism of proteins
R-HSA-167060: NGF processing
R-HSA-597592: Post-translational protein modification
R-HSA-1912422: Pre-NOTCH Expression and Processing
R-HSA-1912420: Pre-NOTCH Processing in Golgi
R-HSA-159782: Removal of aminoterminal propeptides from gamma-carboxylated proteins
R-HSA-162582: Signal Transduction
R-HSA-1181150: Signaling by NODAL
R-HSA-157118: Signaling by NOTCH
R-HSA-186797: Signaling by PDGF
R-HSA-170834: Signaling by TGF-beta Receptor Complex
R-HSA-166520: Signalling by NGF
R-HSA-171286: Synthesis and processing of ENV and VPU
R-HSA-2173789: TGF-beta receptor signaling activates SMADs
R-HSA-5339562: Uptake and actions of bacterial toxins
R-HSA-5210891: Uptake and function of anthrax toxins
Summary
SymbolFURIN
Namefurin (paired basic amino acid cleaving enzyme)
Aliases PCSK3; FUR; PACE; paired basic amino acid cleaving enzyme (furin, membrane associated receptor protein); FES ......
Chromosomal Location15q26.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between FURIN and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between FURIN and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
29704427Breast CarcinomaInhibit immunityCo-immunoprecipitation and immunofluorescence cell staining assays revealed that interaction of Plac1 and Furin degraded Notch1 and generated Notch1 intracellular domain (NICD) that could inhibit PTEN activity. A rescue study showed that inhibition of Furin and overexpression of PTEN in Plac1 overexpression cells blocked Plac1-induced tumor cell progression.
Summary
SymbolFURIN
Namefurin (paired basic amino acid cleaving enzyme)
Aliases PCSK3; FUR; PACE; paired basic amino acid cleaving enzyme (furin, membrane associated receptor protein); FES ......
Chromosomal Location15q26.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of FURIN in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell logFC: 0.71; FDR: 0.048000 Sensitive to T cell-mediated killing
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolFURIN
Namefurin (paired basic amino acid cleaving enzyme)
Aliases PCSK3; FUR; PACE; paired basic amino acid cleaving enzyme (furin, membrane associated receptor protein); FES ......
Chromosomal Location15q26.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of FURIN in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.3110.34
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.0270.992
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.5320.758
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.0250.948
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.1350.954
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.1150.97
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.3080.541
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.1910.914
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.4010.842
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.5370.717
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.0050.646
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0420.65
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of FURIN in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141705.9-5.91
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 41407.1-7.11
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277305.5-5.50.572
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 01407.1-7.11
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275905.1-5.10.549
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211705.9-5.90.447
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)86016.7-16.70.429
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.16.24.91
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 592011.18.91
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.305.30.507
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolFURIN
Namefurin (paired basic amino acid cleaving enzyme)
Aliases PCSK3; FUR; PACE; paired basic amino acid cleaving enzyme (furin, membrane associated receptor protein); FES ......
Chromosomal Location15q26.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FURIN. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolFURIN
Namefurin (paired basic amino acid cleaving enzyme)
Aliases PCSK3; FUR; PACE; paired basic amino acid cleaving enzyme (furin, membrane associated receptor protein); FES ......
Chromosomal Location15q26.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FURIN. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FURIN.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolFURIN
Namefurin (paired basic amino acid cleaving enzyme)
Aliases PCSK3; FUR; PACE; paired basic amino acid cleaving enzyme (furin, membrane associated receptor protein); FES ......
Chromosomal Location15q26.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FURIN. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolFURIN
Namefurin (paired basic amino acid cleaving enzyme)
Aliases PCSK3; FUR; PACE; paired basic amino acid cleaving enzyme (furin, membrane associated receptor protein); FES ......
Chromosomal Location15q26.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of FURIN expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolFURIN
Namefurin (paired basic amino acid cleaving enzyme)
Aliases PCSK3; FUR; PACE; paired basic amino acid cleaving enzyme (furin, membrane associated receptor protein); FES ......
Chromosomal Location15q26.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between FURIN and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolFURIN
Namefurin (paired basic amino acid cleaving enzyme)
Aliases PCSK3; FUR; PACE; paired basic amino acid cleaving enzyme (furin, membrane associated receptor protein); FES ......
Chromosomal Location15q26.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting FURIN collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting FURIN.
ID Name Drug Type Targets #Targets
DB03600Capric acidSmall MoleculeFURIN, GLTP, PPARG3
DB04951PirfenidoneSmall MoleculeFURIN1