Summary | |
---|---|
Symbol | FUT4 |
Name | fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) |
Aliases | FUC-TIV; ELAM ligand fucosyltransferase; CD15; ELFT; FUTIV; LeX; SSEA-1; ELAM-1 ligand fucosyltransferase; L ...... |
Chromosomal Location | 11q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi. |
Domain |
PF17039 Fucosyltransferase PF00852 Glycosyltransferase family 10 (fucosyltransferase) C-term |
Function |
May catalyze alpha-1,3 glycosidic linkages involved in the expression of Lewis X/SSEA-1 and VIM-2 antigens. |
Biological Process |
GO:0005996 monosaccharide metabolic process GO:0006004 fucose metabolic process GO:0006486 protein glycosylation GO:0006487 protein N-linked glycosylation GO:0009100 glycoprotein metabolic process GO:0009101 glycoprotein biosynthetic process GO:0016052 carbohydrate catabolic process GO:0019317 fucose catabolic process GO:0019318 hexose metabolic process GO:0019320 hexose catabolic process GO:0036065 fucosylation GO:0042354 L-fucose metabolic process GO:0042355 L-fucose catabolic process GO:0043413 macromolecule glycosylation GO:0044282 small molecule catabolic process GO:0044723 single-organism carbohydrate metabolic process GO:0044724 single-organism carbohydrate catabolic process GO:0046365 monosaccharide catabolic process GO:0070085 glycosylation |
Molecular Function |
GO:0008417 fucosyltransferase activity GO:0016757 transferase activity, transferring glycosyl groups GO:0016758 transferase activity, transferring hexosyl groups GO:0046920 alpha-(1->3)-fucosyltransferase activity |
Cellular Component |
GO:0005795 Golgi stack GO:0031984 organelle subcompartment GO:0031985 Golgi cisterna GO:0032580 Golgi cisterna membrane GO:0098791 Golgi subcompartment |
KEGG |
hsa00601 Glycosphingolipid biosynthesis - lacto and neolacto series hsa01100 Metabolic pathways |
Reactome | - |
Summary | |
---|---|
Symbol | FUT4 |
Name | fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) |
Aliases | FUC-TIV; ELAM ligand fucosyltransferase; CD15; ELFT; FUTIV; LeX; SSEA-1; ELAM-1 ligand fucosyltransferase; L ...... |
Chromosomal Location | 11q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between FUT4 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between FUT4 and anti-tumor immunity in human cancer.
|
Summary | |
---|---|
Symbol | FUT4 |
Name | fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) |
Aliases | FUC-TIV; ELAM ligand fucosyltransferase; CD15; ELFT; FUTIV; LeX; SSEA-1; ELAM-1 ligand fucosyltransferase; L ...... |
Chromosomal Location | 11q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of FUT4 in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | FUT4 |
Name | fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) |
Aliases | FUC-TIV; ELAM ligand fucosyltransferase; CD15; ELFT; FUTIV; LeX; SSEA-1; ELAM-1 ligand fucosyltransferase; L ...... |
Chromosomal Location | 11q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of FUT4 in various data sets.
|
Points in the above scatter plot represent the mutation difference of FUT4 in various data sets.
|
Summary | |
---|---|
Symbol | FUT4 |
Name | fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) |
Aliases | FUC-TIV; ELAM ligand fucosyltransferase; CD15; ELFT; FUTIV; LeX; SSEA-1; ELAM-1 ligand fucosyltransferase; L ...... |
Chromosomal Location | 11q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FUT4. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | FUT4 |
Name | fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) |
Aliases | FUC-TIV; ELAM ligand fucosyltransferase; CD15; ELFT; FUTIV; LeX; SSEA-1; ELAM-1 ligand fucosyltransferase; L ...... |
Chromosomal Location | 11q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FUT4. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FUT4. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | FUT4 |
Name | fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) |
Aliases | FUC-TIV; ELAM ligand fucosyltransferase; CD15; ELFT; FUTIV; LeX; SSEA-1; ELAM-1 ligand fucosyltransferase; L ...... |
Chromosomal Location | 11q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FUT4. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | FUT4 |
Name | fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) |
Aliases | FUC-TIV; ELAM ligand fucosyltransferase; CD15; ELFT; FUTIV; LeX; SSEA-1; ELAM-1 ligand fucosyltransferase; L ...... |
Chromosomal Location | 11q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of FUT4 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | FUT4 |
Name | fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) |
Aliases | FUC-TIV; ELAM ligand fucosyltransferase; CD15; ELFT; FUTIV; LeX; SSEA-1; ELAM-1 ligand fucosyltransferase; L ...... |
Chromosomal Location | 11q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between FUT4 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | FUT4 |
Name | fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) |
Aliases | FUC-TIV; ELAM ligand fucosyltransferase; CD15; ELFT; FUTIV; LeX; SSEA-1; ELAM-1 ligand fucosyltransferase; L ...... |
Chromosomal Location | 11q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting FUT4 collected from DrugBank database. |
There is no record. |