Summary | |
---|---|
Symbol | FXYD2 |
Name | FXYD domain containing ion transport regulator 2 |
Aliases | MGC12372; ATP1G1; HOMG2; hypomagnesemia 2, renal; ATPase, Na+/K+ transporting, gamma 1 polypeptide; Na(+)/K( ...... |
Chromosomal Location | 11q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane Single-pass type III membrane protein |
Domain |
PF02038 ATP1G1/PLM/MAT8 family |
Function |
May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase. |
Biological Process |
GO:0001558 regulation of cell growth GO:0002028 regulation of sodium ion transport GO:0003013 circulatory system process GO:0003015 heart process GO:0006813 potassium ion transport GO:0006814 sodium ion transport GO:0008015 blood circulation GO:0008016 regulation of heart contraction GO:0010107 potassium ion import GO:0010248 establishment or maintenance of transmembrane electrochemical gradient GO:0010959 regulation of metal ion transport GO:0015672 monovalent inorganic cation transport GO:0016049 cell growth GO:0022898 regulation of transmembrane transporter activity GO:0032409 regulation of transporter activity GO:0032412 regulation of ion transmembrane transporter activity GO:0034762 regulation of transmembrane transport GO:0034765 regulation of ion transmembrane transport GO:0035637 multicellular organismal signaling GO:0035725 sodium ion transmembrane transport GO:0036376 sodium ion export from cell GO:0044057 regulation of system process GO:0060047 heart contraction GO:0061337 cardiac conduction GO:0071436 sodium ion export GO:0071804 cellular potassium ion transport GO:0071805 potassium ion transmembrane transport GO:0090662 ATP hydrolysis coupled transmembrane transport GO:0098657 import into cell GO:0098739 import across plasma membrane GO:1902305 regulation of sodium ion transmembrane transport GO:1903522 regulation of blood circulation GO:1903779 regulation of cardiac conduction GO:1904062 regulation of cation transmembrane transport GO:1990573 potassium ion import across plasma membrane GO:2000649 regulation of sodium ion transmembrane transporter activity |
Molecular Function |
GO:0005216 ion channel activity GO:0005391 sodium:potassium-exchanging ATPase activity GO:0008556 potassium-transporting ATPase activity GO:0015077 monovalent inorganic cation transmembrane transporter activity GO:0015079 potassium ion transmembrane transporter activity GO:0015081 sodium ion transmembrane transporter activity GO:0015267 channel activity GO:0015399 primary active transmembrane transporter activity GO:0015405 P-P-bond-hydrolysis-driven transmembrane transporter activity GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GO:0016247 channel regulator activity GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GO:0016887 ATPase activity GO:0017080 sodium channel regulator activity GO:0019829 cation-transporting ATPase activity GO:0022803 passive transmembrane transporter activity GO:0022804 active transmembrane transporter activity GO:0022838 substrate-specific channel activity GO:0022853 active ion transmembrane transporter activity GO:0042623 ATPase activity, coupled GO:0042625 ATPase coupled ion transmembrane transporter activity GO:0042626 ATPase activity, coupled to transmembrane movement of substances GO:0043492 ATPase activity, coupled to movement of substances GO:0046873 metal ion transmembrane transporter activity |
Cellular Component |
GO:0005890 sodium:potassium-exchanging ATPase complex GO:0016323 basolateral plasma membrane GO:0090533 cation-transporting ATPase complex GO:0098533 ATPase dependent transmembrane transport complex GO:1902495 transmembrane transporter complex GO:1904949 ATPase complex GO:1990351 transporter complex |
KEGG |
hsa04022 cGMP-PKG signaling pathway hsa04024 cAMP signaling pathway hsa04260 Cardiac muscle contraction hsa04261 Adrenergic signaling in cardiomyocytes hsa04911 Insulin secretion hsa04918 Thyroid hormone synthesis hsa04919 Thyroid hormone signaling pathway hsa04960 Aldosterone-regulated sodium reabsorption hsa04961 Endocrine and other factor-regulated calcium reabsorption hsa04964 Proximal tubule bicarbonate reclamation hsa04970 Salivary secretion hsa04972 Pancreatic secretion hsa04973 Carbohydrate digestion and absorption hsa04974 Protein digestion and absorption hsa04976 Bile secretion hsa04978 Mineral absorption |
Reactome |
R-HSA-5576891: Cardiac conduction R-HSA-983712: Ion channel transport R-HSA-5578775: Ion homeostasis R-HSA-936837: Ion transport by P-type ATPases R-HSA-397014: Muscle contraction R-HSA-382551: Transmembrane transport of small molecules |
Summary | |
---|---|
Symbol | FXYD2 |
Name | FXYD domain containing ion transport regulator 2 |
Aliases | MGC12372; ATP1G1; HOMG2; hypomagnesemia 2, renal; ATPase, Na+/K+ transporting, gamma 1 polypeptide; Na(+)/K( ...... |
Chromosomal Location | 11q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between FXYD2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | FXYD2 |
Name | FXYD domain containing ion transport regulator 2 |
Aliases | MGC12372; ATP1G1; HOMG2; hypomagnesemia 2, renal; ATPase, Na+/K+ transporting, gamma 1 polypeptide; Na(+)/K( ...... |
Chromosomal Location | 11q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of FXYD2 in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | FXYD2 |
Name | FXYD domain containing ion transport regulator 2 |
Aliases | MGC12372; ATP1G1; HOMG2; hypomagnesemia 2, renal; ATPase, Na+/K+ transporting, gamma 1 polypeptide; Na(+)/K( ...... |
Chromosomal Location | 11q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of FXYD2 in various data sets.
|
Points in the above scatter plot represent the mutation difference of FXYD2 in various data sets.
|
Summary | |
---|---|
Symbol | FXYD2 |
Name | FXYD domain containing ion transport regulator 2 |
Aliases | MGC12372; ATP1G1; HOMG2; hypomagnesemia 2, renal; ATPase, Na+/K+ transporting, gamma 1 polypeptide; Na(+)/K( ...... |
Chromosomal Location | 11q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FXYD2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | FXYD2 |
Name | FXYD domain containing ion transport regulator 2 |
Aliases | MGC12372; ATP1G1; HOMG2; hypomagnesemia 2, renal; ATPase, Na+/K+ transporting, gamma 1 polypeptide; Na(+)/K( ...... |
Chromosomal Location | 11q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FXYD2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FXYD2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | FXYD2 |
Name | FXYD domain containing ion transport regulator 2 |
Aliases | MGC12372; ATP1G1; HOMG2; hypomagnesemia 2, renal; ATPase, Na+/K+ transporting, gamma 1 polypeptide; Na(+)/K( ...... |
Chromosomal Location | 11q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FXYD2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | FXYD2 |
Name | FXYD domain containing ion transport regulator 2 |
Aliases | MGC12372; ATP1G1; HOMG2; hypomagnesemia 2, renal; ATPase, Na+/K+ transporting, gamma 1 polypeptide; Na(+)/K( ...... |
Chromosomal Location | 11q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of FXYD2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | FXYD2 |
Name | FXYD domain containing ion transport regulator 2 |
Aliases | MGC12372; ATP1G1; HOMG2; hypomagnesemia 2, renal; ATPase, Na+/K+ transporting, gamma 1 polypeptide; Na(+)/K( ...... |
Chromosomal Location | 11q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between FXYD2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | FXYD2 |
Name | FXYD domain containing ion transport regulator 2 |
Aliases | MGC12372; ATP1G1; HOMG2; hypomagnesemia 2, renal; ATPase, Na+/K+ transporting, gamma 1 polypeptide; Na(+)/K( ...... |
Chromosomal Location | 11q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting FXYD2 collected from DrugBank database. |
Details on drugs targeting FXYD2.
|