Browse FZD4

Summary
SymbolFZD4
Namefrizzled class receptor 4
Aliases CD344; frizzled (Drosophila) homolog 4; frizzled homolog 4 (Drosophila); frizzled 4, seven transmembrane spa ......
Chromosomal Location11q14-q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Membrane; Multi-pass membrane protein. Cell membrane Multi-pass membrane protein
Domain PF01534 Frizzled/Smoothened family membrane region
PF01392 Fz domain
Function

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes. Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP). In retina, it can be both activated by Wnt protein-binding, but also by a Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

> Gene Ontology
 
Biological Process GO:0001101 response to acid chemical
GO:0001553 luteinization
GO:0001570 vasculogenesis
GO:0001654 eye development
GO:0001736 establishment of planar polarity
GO:0001738 morphogenesis of a polarized epithelium
GO:0006869 lipid transport
GO:0007162 negative regulation of cell adhesion
GO:0007164 establishment of tissue polarity
GO:0007223 Wnt signaling pathway, calcium modulating pathway
GO:0007254 JNK cascade
GO:0007423 sensory organ development
GO:0007548 sex differentiation
GO:0007605 sensory perception of sound
GO:0007626 locomotory behavior
GO:0008406 gonad development
GO:0008585 female gonad development
GO:0009914 hormone transport
GO:0010810 regulation of cell-substrate adhesion
GO:0010812 negative regulation of cell-substrate adhesion
GO:0010817 regulation of hormone levels
GO:0010876 lipid localization
GO:0016055 Wnt signaling pathway
GO:0021549 cerebellum development
GO:0022037 metencephalon development
GO:0022412 cellular process involved in reproduction in multicellular organism
GO:0022602 ovulation cycle process
GO:0023061 signal release
GO:0030902 hindbrain development
GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031098 stress-activated protein kinase signaling cascade
GO:0031589 cell-substrate adhesion
GO:0031987 locomotion involved in locomotory behavior
GO:0032526 response to retinoic acid
GO:0032872 regulation of stress-activated MAPK cascade
GO:0032874 positive regulation of stress-activated MAPK cascade
GO:0033674 positive regulation of kinase activity
GO:0034446 substrate adhesion-dependent cell spreading
GO:0035426 extracellular matrix-cell signaling
GO:0035567 non-canonical Wnt signaling pathway
GO:0035929 steroid hormone secretion
GO:0042698 ovulation cycle
GO:0042701 progesterone secretion
GO:0043010 camera-type eye development
GO:0043405 regulation of MAP kinase activity
GO:0043406 positive regulation of MAP kinase activity
GO:0043410 positive regulation of MAPK cascade
GO:0043506 regulation of JUN kinase activity
GO:0043507 positive regulation of JUN kinase activity
GO:0045137 development of primary sexual characteristics
GO:0045860 positive regulation of protein kinase activity
GO:0046328 regulation of JNK cascade
GO:0046330 positive regulation of JNK cascade
GO:0046545 development of primary female sexual characteristics
GO:0046660 female sex differentiation
GO:0046879 hormone secretion
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048511 rhythmic process
GO:0048514 blood vessel morphogenesis
GO:0048608 reproductive structure development
GO:0050886 endocrine process
GO:0050954 sensory perception of mechanical stimulus
GO:0051090 regulation of sequence-specific DNA binding transcription factor activity
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051403 stress-activated MAPK cascade
GO:0060041 retina development in camera-type eye
GO:0060070 canonical Wnt signaling pathway
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0060986 endocrine hormone secretion
GO:0061298 retina vasculature development in camera-type eye
GO:0061299 retina vasculature morphogenesis in camera-type eye
GO:0061300 cerebellum vasculature development
GO:0061301 cerebellum vasculature morphogenesis
GO:0061304 retinal blood vessel morphogenesis
GO:0061458 reproductive system development
GO:0070302 regulation of stress-activated protein kinase signaling cascade
GO:0070304 positive regulation of stress-activated protein kinase signaling cascade
GO:0071229 cellular response to acid chemical
GO:0071300 cellular response to retinoic acid
GO:0071396 cellular response to lipid
GO:0071900 regulation of protein serine/threonine kinase activity
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0090175 regulation of establishment of planar polarity
GO:0090287 regulation of cellular response to growth factor stimulus
GO:0198738 cell-cell signaling by wnt
GO:1905330 regulation of morphogenesis of an epithelium
GO:2000027 regulation of organ morphogenesis
Molecular Function GO:0017147 Wnt-protein binding
GO:0019955 cytokine binding
GO:0030165 PDZ domain binding
GO:0031625 ubiquitin protein ligase binding
GO:0042813 Wnt-activated receptor activity
GO:0044389 ubiquitin-like protein ligase binding
GO:0046982 protein heterodimerization activity
Cellular Component GO:0030135 coated vesicle
GO:0030136 clathrin-coated vesicle
GO:0030139 endocytic vesicle
GO:0030659 cytoplasmic vesicle membrane
GO:0030662 coated vesicle membrane
GO:0030665 clathrin-coated vesicle membrane
GO:0030666 endocytic vesicle membrane
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0045334 clathrin-coated endocytic vesicle
> KEGG and Reactome Pathway
 
KEGG hsa04150 mTOR signaling pathway
hsa04310 Wnt signaling pathway
hsa04390 Hippo signaling pathway
hsa04550 Signaling pathways regulating pluripotency of stem cells
hsa04916 Melanogenesis
Reactome R-HSA-4608870: Asymmetric localization of PCP proteins
R-HSA-3858494: Beta-catenin independent WNT signaling
R-HSA-4086398: Ca2+ pathway
R-HSA-8856825: Cargo recognition for clathrin-mediated endocytosis
R-HSA-373080: Class B/2 (Secretin family receptors)
R-HSA-8856828: Clathrin-mediated endocytosis
R-HSA-1643685: Disease
R-HSA-5663202: Diseases of signal transduction
R-HSA-500792: GPCR ligand binding
R-HSA-199991: Membrane Trafficking
R-HSA-4086400: PCP/CE pathway
R-HSA-5340588: RNF mutants show enhanced WNT signaling and proliferation
R-HSA-4641263: Regulation of FZD by ubiquitination
R-HSA-162582: Signal Transduction
R-HSA-372790: Signaling by GPCR
R-HSA-4791275: Signaling by WNT in cancer
R-HSA-195721: Signaling by Wnt
R-HSA-201681: TCF dependent signaling in response to WNT
R-HSA-5653656: Vesicle-mediated transport
R-HSA-5099900: WNT5A-dependent internalization of FZD4
Summary
SymbolFZD4
Namefrizzled class receptor 4
Aliases CD344; frizzled (Drosophila) homolog 4; frizzled homolog 4 (Drosophila); frizzled 4, seven transmembrane spa ......
Chromosomal Location11q14-q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between FZD4 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolFZD4
Namefrizzled class receptor 4
Aliases CD344; frizzled (Drosophila) homolog 4; frizzled homolog 4 (Drosophila); frizzled 4, seven transmembrane spa ......
Chromosomal Location11q14-q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of FZD4 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.52 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolFZD4
Namefrizzled class receptor 4
Aliases CD344; frizzled (Drosophila) homolog 4; frizzled homolog 4 (Drosophila); frizzled 4, seven transmembrane spa ......
Chromosomal Location11q14-q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of FZD4 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.5080.0659
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.560.615
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.4720.584
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.4760.195
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.3420.831
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.640.734
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.2280.546
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.3330.806
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.0870.955
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.8460.596
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.8880.382
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.3180.0113
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of FZD4 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.703.70.27
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.703.70.314
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 382703.7-3.70.415
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 221307.7-7.70.371
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolFZD4
Namefrizzled class receptor 4
Aliases CD344; frizzled (Drosophila) homolog 4; frizzled homolog 4 (Drosophila); frizzled 4, seven transmembrane spa ......
Chromosomal Location11q14-q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FZD4. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolFZD4
Namefrizzled class receptor 4
Aliases CD344; frizzled (Drosophila) homolog 4; frizzled homolog 4 (Drosophila); frizzled 4, seven transmembrane spa ......
Chromosomal Location11q14-q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FZD4. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FZD4.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolFZD4
Namefrizzled class receptor 4
Aliases CD344; frizzled (Drosophila) homolog 4; frizzled homolog 4 (Drosophila); frizzled 4, seven transmembrane spa ......
Chromosomal Location11q14-q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FZD4. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolFZD4
Namefrizzled class receptor 4
Aliases CD344; frizzled (Drosophila) homolog 4; frizzled homolog 4 (Drosophila); frizzled 4, seven transmembrane spa ......
Chromosomal Location11q14-q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of FZD4 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolFZD4
Namefrizzled class receptor 4
Aliases CD344; frizzled (Drosophila) homolog 4; frizzled homolog 4 (Drosophila); frizzled 4, seven transmembrane spa ......
Chromosomal Location11q14-q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between FZD4 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolFZD4
Namefrizzled class receptor 4
Aliases CD344; frizzled (Drosophila) homolog 4; frizzled homolog 4 (Drosophila); frizzled 4, seven transmembrane spa ......
Chromosomal Location11q14-q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting FZD4 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.