Browse FZD7

Summary
SymbolFZD7
Namefrizzled class receptor 7
Aliases FzE3; frizzled (Drosophila) homolog 7; frizzled homolog 7 (Drosophila); frizzled 7, seven transmembrane span ......
Chromosomal Location2q33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane Multi-pass membrane protein Endosome membrane Multi-pass membrane protein Note=Associated to the plasma membrane in the presence of FZD7 and phosphatidylinositol 4,5-bisphosphate (PIP2). Localized in recycling endosomes in other conditions.
Domain PF01534 Frizzled/Smoothened family membrane region
PF01392 Fz domain
Function

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

> Gene Ontology
 
Biological Process GO:0001101 response to acid chemical
GO:0001704 formation of primary germ layer
GO:0001705 ectoderm formation
GO:0001708 cell fate specification
GO:0001712 ectodermal cell fate commitment
GO:0001715 ectodermal cell fate specification
GO:0001736 establishment of planar polarity
GO:0001738 morphogenesis of a polarized epithelium
GO:0002521 leukocyte differentiation
GO:0006606 protein import into nucleus
GO:0006913 nucleocytoplasmic transport
GO:0007159 leukocyte cell-cell adhesion
GO:0007162 negative regulation of cell adhesion
GO:0007164 establishment of tissue polarity
GO:0007254 JNK cascade
GO:0007369 gastrulation
GO:0007398 ectoderm development
GO:0009996 negative regulation of cell fate specification
GO:0010453 regulation of cell fate commitment
GO:0010454 negative regulation of cell fate commitment
GO:0010470 regulation of gastrulation
GO:0010668 ectodermal cell differentiation
GO:0010810 regulation of cell-substrate adhesion
GO:0010812 negative regulation of cell-substrate adhesion
GO:0014834 skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
GO:0016055 Wnt signaling pathway
GO:0017038 protein import
GO:0017145 stem cell division
GO:0019827 stem cell population maintenance
GO:0030098 lymphocyte differentiation
GO:0030217 T cell differentiation
GO:0031098 stress-activated protein kinase signaling cascade
GO:0031099 regeneration
GO:0031589 cell-substrate adhesion
GO:0032386 regulation of intracellular transport
GO:0032526 response to retinoic acid
GO:0032872 regulation of stress-activated MAPK cascade
GO:0032874 positive regulation of stress-activated MAPK cascade
GO:0033077 T cell differentiation in thymus
GO:0033157 regulation of intracellular protein transport
GO:0034446 substrate adhesion-dependent cell spreading
GO:0034504 protein localization to nucleus
GO:0035411 catenin import into nucleus
GO:0035412 regulation of catenin import into nucleus
GO:0035567 non-canonical Wnt signaling pathway
GO:0038030 non-canonical Wnt signaling pathway via MAPK cascade
GO:0038031 non-canonical Wnt signaling pathway via JNK cascade
GO:0042110 T cell activation
GO:0042246 tissue regeneration
GO:0042306 regulation of protein import into nucleus
GO:0042659 regulation of cell fate specification
GO:0042665 regulation of ectodermal cell fate specification
GO:0042666 negative regulation of ectodermal cell fate specification
GO:0043403 skeletal muscle tissue regeneration
GO:0043410 positive regulation of MAPK cascade
GO:0044744 protein targeting to nucleus
GO:0045165 cell fate commitment
GO:0045992 negative regulation of embryonic development
GO:0045995 regulation of embryonic development
GO:0046328 regulation of JNK cascade
GO:0046330 positive regulation of JNK cascade
GO:0046822 regulation of nucleocytoplasmic transport
GO:0048103 somatic stem cell division
GO:0050673 epithelial cell proliferation
GO:0050678 regulation of epithelial cell proliferation
GO:0050679 positive regulation of epithelial cell proliferation
GO:0051169 nuclear transport
GO:0051170 nuclear import
GO:0051403 stress-activated MAPK cascade
GO:0060054 positive regulation of epithelial cell proliferation involved in wound healing
GO:0060070 canonical Wnt signaling pathway
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0060231 mesenchymal to epithelial transition
GO:0060795 cell fate commitment involved in formation of primary germ layer
GO:0070302 regulation of stress-activated protein kinase signaling cascade
GO:0070304 positive regulation of stress-activated protein kinase signaling cascade
GO:0070486 leukocyte aggregation
GO:0070489 T cell aggregation
GO:0071229 cellular response to acid chemical
GO:0071300 cellular response to retinoic acid
GO:0071396 cellular response to lipid
GO:0071593 lymphocyte aggregation
GO:0071594 thymocyte aggregation
GO:0090175 regulation of establishment of planar polarity
GO:0098727 maintenance of cell number
GO:0198738 cell-cell signaling by wnt
GO:1900180 regulation of protein localization to nucleus
GO:1902593 single-organism nuclear import
GO:1903533 regulation of protein targeting
GO:1904589 regulation of protein import
GO:1905330 regulation of morphogenesis of an epithelium
GO:2000027 regulation of organ morphogenesis
GO:2000383 regulation of ectoderm development
GO:2000384 negative regulation of ectoderm development
GO:2000542 negative regulation of gastrulation
Molecular Function GO:0001664 G-protein coupled receptor binding
GO:0005109 frizzled binding
GO:0017147 Wnt-protein binding
GO:0030165 PDZ domain binding
GO:0042813 Wnt-activated receptor activity
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa04150 mTOR signaling pathway
hsa04310 Wnt signaling pathway
hsa04390 Hippo signaling pathway
hsa04550 Signaling pathways regulating pluripotency of stem cells
hsa04916 Melanogenesis
Reactome R-HSA-4608870: Asymmetric localization of PCP proteins
R-HSA-3858494: Beta-catenin independent WNT signaling
R-HSA-373080: Class B/2 (Secretin family receptors)
R-HSA-500792: GPCR ligand binding
R-HSA-4086400: PCP/CE pathway
R-HSA-162582: Signal Transduction
R-HSA-372790: Signaling by GPCR
R-HSA-195721: Signaling by Wnt
Summary
SymbolFZD7
Namefrizzled class receptor 7
Aliases FzE3; frizzled (Drosophila) homolog 7; frizzled homolog 7 (Drosophila); frizzled 7, seven transmembrane span ......
Chromosomal Location2q33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between FZD7 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between FZD7 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
29411237Triple-Negative Breast CarcinomaEssential for immunityThe scFvs inhibited cell growth of MDA-MB-231 cells significantly as compared to untreated cells. Growth inhibition of 58.6 and 53.1% were detected for scFv-I and scFv-II, respectively. No significant growth inhibition was detected for SKBR-3 negative control cells. The scFvs induced apoptotic effects in the MDA-MB-231 treated cells after 48?h, which were 81.6 and 74.9% for scFv-I and scFv-II, respectively. Downregulation of Surivin, c-Myc and Dvl genes were also shown after 48h treatment of cells with either of scFvs (59.3-93.8%).
Summary
SymbolFZD7
Namefrizzled class receptor 7
Aliases FzE3; frizzled (Drosophila) homolog 7; frizzled homolog 7 (Drosophila); frizzled 7, seven transmembrane span ......
Chromosomal Location2q33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of FZD7 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolFZD7
Namefrizzled class receptor 7
Aliases FzE3; frizzled (Drosophila) homolog 7; frizzled homolog 7 (Drosophila); frizzled 7, seven transmembrane span ......
Chromosomal Location2q33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of FZD7 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.4050.449
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.8540.652
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.0660.959
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.3340.523
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.5720.757
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.0350.988
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.3410.5
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.0820.954
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.660.666
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.4430.621
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.2970.816
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.2940.00957
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of FZD7 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.71.42.30.469
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.71.720.532
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolFZD7
Namefrizzled class receptor 7
Aliases FzE3; frizzled (Drosophila) homolog 7; frizzled homolog 7 (Drosophila); frizzled 7, seven transmembrane span ......
Chromosomal Location2q33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FZD7. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolFZD7
Namefrizzled class receptor 7
Aliases FzE3; frizzled (Drosophila) homolog 7; frizzled homolog 7 (Drosophila); frizzled 7, seven transmembrane span ......
Chromosomal Location2q33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FZD7. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FZD7.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolFZD7
Namefrizzled class receptor 7
Aliases FzE3; frizzled (Drosophila) homolog 7; frizzled homolog 7 (Drosophila); frizzled 7, seven transmembrane span ......
Chromosomal Location2q33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FZD7. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolFZD7
Namefrizzled class receptor 7
Aliases FzE3; frizzled (Drosophila) homolog 7; frizzled homolog 7 (Drosophila); frizzled 7, seven transmembrane span ......
Chromosomal Location2q33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of FZD7 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolFZD7
Namefrizzled class receptor 7
Aliases FzE3; frizzled (Drosophila) homolog 7; frizzled homolog 7 (Drosophila); frizzled 7, seven transmembrane span ......
Chromosomal Location2q33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between FZD7 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolFZD7
Namefrizzled class receptor 7
Aliases FzE3; frizzled (Drosophila) homolog 7; frizzled homolog 7 (Drosophila); frizzled 7, seven transmembrane span ......
Chromosomal Location2q33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting FZD7 collected from DrugBank database.
> Drugs from DrugBank database
 

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