Browse GABPA

Summary
SymbolGABPA
NameGA binding protein transcription factor, alpha subunit 60kDa
Aliases E4TF1A; NFT2; E4TF1-60; NRF2A; human nuclear respiratory factor-2 subunit alpha; nuclear respiratory factor ......
Chromosomal Location21q21-q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus.
Domain PF00178 Ets-domain
PF11620 GA-binding protein alpha chain
PF02198 Sterile alpha motif (SAM)/Pointed domain
Function

Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the expression of the Adenovirus E4 gene.

> Gene Ontology
 
Biological Process GO:0001701 in utero embryonic development
GO:0002683 negative regulation of immune system process
GO:0030099 myeloid cell differentiation
GO:0030219 megakaryocyte differentiation
GO:0045637 regulation of myeloid cell differentiation
GO:0045638 negative regulation of myeloid cell differentiation
GO:0045652 regulation of megakaryocyte differentiation
GO:0045653 negative regulation of megakaryocyte differentiation
GO:1903706 regulation of hemopoiesis
GO:1903707 negative regulation of hemopoiesis
Molecular Function GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0000987 core promoter proximal region sequence-specific DNA binding
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001159 core promoter proximal region DNA binding
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0003682 chromatin binding
GO:0003713 transcription coactivator activity
GO:0046982 protein heterodimerization activity
Cellular Component GO:0000785 chromatin
GO:0000790 nuclear chromatin
GO:0044454 nuclear chromosome part
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-1592230: Mitochondrial biogenesis
R-HSA-1852241: Organelle biogenesis and maintenance
R-HSA-2151201: Transcriptional activation of mitochondrial biogenesis
Summary
SymbolGABPA
NameGA binding protein transcription factor, alpha subunit 60kDa
Aliases E4TF1A; NFT2; E4TF1-60; NRF2A; human nuclear respiratory factor-2 subunit alpha; nuclear respiratory factor ......
Chromosomal Location21q21-q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between GABPA and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolGABPA
NameGA binding protein transcription factor, alpha subunit 60kDa
Aliases E4TF1A; NFT2; E4TF1-60; NRF2A; human nuclear respiratory factor-2 subunit alpha; nuclear respiratory factor ......
Chromosomal Location21q21-q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of GABPA in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.87 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolGABPA
NameGA binding protein transcription factor, alpha subunit 60kDa
Aliases E4TF1A; NFT2; E4TF1-60; NRF2A; human nuclear respiratory factor-2 subunit alpha; nuclear respiratory factor ......
Chromosomal Location21q21-q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of GABPA in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.0370.92
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.310.838
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.1650.881
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.3280.437
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.0620.961
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.6740.708
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0450.906
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.0870.96
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.0220.991
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.1910.837
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.9190.496
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.1730.00223
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of GABPA in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277301.4-1.41
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275901.7-1.71
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.305.30.507
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22139.109.10.519
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolGABPA
NameGA binding protein transcription factor, alpha subunit 60kDa
Aliases E4TF1A; NFT2; E4TF1-60; NRF2A; human nuclear respiratory factor-2 subunit alpha; nuclear respiratory factor ......
Chromosomal Location21q21-q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GABPA. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolGABPA
NameGA binding protein transcription factor, alpha subunit 60kDa
Aliases E4TF1A; NFT2; E4TF1-60; NRF2A; human nuclear respiratory factor-2 subunit alpha; nuclear respiratory factor ......
Chromosomal Location21q21-q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GABPA. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GABPA.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolGABPA
NameGA binding protein transcription factor, alpha subunit 60kDa
Aliases E4TF1A; NFT2; E4TF1-60; NRF2A; human nuclear respiratory factor-2 subunit alpha; nuclear respiratory factor ......
Chromosomal Location21q21-q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GABPA. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolGABPA
NameGA binding protein transcription factor, alpha subunit 60kDa
Aliases E4TF1A; NFT2; E4TF1-60; NRF2A; human nuclear respiratory factor-2 subunit alpha; nuclear respiratory factor ......
Chromosomal Location21q21-q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of GABPA expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolGABPA
NameGA binding protein transcription factor, alpha subunit 60kDa
Aliases E4TF1A; NFT2; E4TF1-60; NRF2A; human nuclear respiratory factor-2 subunit alpha; nuclear respiratory factor ......
Chromosomal Location21q21-q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between GABPA and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolGABPA
NameGA binding protein transcription factor, alpha subunit 60kDa
Aliases E4TF1A; NFT2; E4TF1-60; NRF2A; human nuclear respiratory factor-2 subunit alpha; nuclear respiratory factor ......
Chromosomal Location21q21-q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting GABPA collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.