Summary | |
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Symbol | GABPA |
Name | GA binding protein transcription factor, alpha subunit 60kDa |
Aliases | E4TF1A; NFT2; E4TF1-60; NRF2A; human nuclear respiratory factor-2 subunit alpha; nuclear respiratory factor ...... |
Chromosomal Location | 21q21-q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus. |
Domain |
PF00178 Ets-domain PF11620 GA-binding protein alpha chain PF02198 Sterile alpha motif (SAM)/Pointed domain |
Function |
Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the expression of the Adenovirus E4 gene. |
Biological Process |
GO:0001701 in utero embryonic development GO:0002683 negative regulation of immune system process GO:0030099 myeloid cell differentiation GO:0030219 megakaryocyte differentiation GO:0045637 regulation of myeloid cell differentiation GO:0045638 negative regulation of myeloid cell differentiation GO:0045652 regulation of megakaryocyte differentiation GO:0045653 negative regulation of megakaryocyte differentiation GO:1903706 regulation of hemopoiesis GO:1903707 negative regulation of hemopoiesis |
Molecular Function |
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0000987 core promoter proximal region sequence-specific DNA binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001159 core promoter proximal region DNA binding GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003682 chromatin binding GO:0003713 transcription coactivator activity GO:0046982 protein heterodimerization activity |
Cellular Component |
GO:0000785 chromatin GO:0000790 nuclear chromatin GO:0044454 nuclear chromosome part |
KEGG | - |
Reactome |
R-HSA-1592230: Mitochondrial biogenesis R-HSA-1852241: Organelle biogenesis and maintenance R-HSA-2151201: Transcriptional activation of mitochondrial biogenesis |
Summary | |
---|---|
Symbol | GABPA |
Name | GA binding protein transcription factor, alpha subunit 60kDa |
Aliases | E4TF1A; NFT2; E4TF1-60; NRF2A; human nuclear respiratory factor-2 subunit alpha; nuclear respiratory factor ...... |
Chromosomal Location | 21q21-q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between GABPA and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | GABPA |
Name | GA binding protein transcription factor, alpha subunit 60kDa |
Aliases | E4TF1A; NFT2; E4TF1-60; NRF2A; human nuclear respiratory factor-2 subunit alpha; nuclear respiratory factor ...... |
Chromosomal Location | 21q21-q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of GABPA in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | GABPA |
Name | GA binding protein transcription factor, alpha subunit 60kDa |
Aliases | E4TF1A; NFT2; E4TF1-60; NRF2A; human nuclear respiratory factor-2 subunit alpha; nuclear respiratory factor ...... |
Chromosomal Location | 21q21-q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of GABPA in various data sets.
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Points in the above scatter plot represent the mutation difference of GABPA in various data sets.
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Summary | |
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Symbol | GABPA |
Name | GA binding protein transcription factor, alpha subunit 60kDa |
Aliases | E4TF1A; NFT2; E4TF1-60; NRF2A; human nuclear respiratory factor-2 subunit alpha; nuclear respiratory factor ...... |
Chromosomal Location | 21q21-q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GABPA. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | GABPA |
Name | GA binding protein transcription factor, alpha subunit 60kDa |
Aliases | E4TF1A; NFT2; E4TF1-60; NRF2A; human nuclear respiratory factor-2 subunit alpha; nuclear respiratory factor ...... |
Chromosomal Location | 21q21-q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GABPA. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GABPA. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | GABPA |
Name | GA binding protein transcription factor, alpha subunit 60kDa |
Aliases | E4TF1A; NFT2; E4TF1-60; NRF2A; human nuclear respiratory factor-2 subunit alpha; nuclear respiratory factor ...... |
Chromosomal Location | 21q21-q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GABPA. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | GABPA |
Name | GA binding protein transcription factor, alpha subunit 60kDa |
Aliases | E4TF1A; NFT2; E4TF1-60; NRF2A; human nuclear respiratory factor-2 subunit alpha; nuclear respiratory factor ...... |
Chromosomal Location | 21q21-q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of GABPA expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | GABPA |
Name | GA binding protein transcription factor, alpha subunit 60kDa |
Aliases | E4TF1A; NFT2; E4TF1-60; NRF2A; human nuclear respiratory factor-2 subunit alpha; nuclear respiratory factor ...... |
Chromosomal Location | 21q21-q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between GABPA and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | GABPA |
Name | GA binding protein transcription factor, alpha subunit 60kDa |
Aliases | E4TF1A; NFT2; E4TF1-60; NRF2A; human nuclear respiratory factor-2 subunit alpha; nuclear respiratory factor ...... |
Chromosomal Location | 21q21-q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting GABPA collected from DrugBank database. |
There is no record. |