Summary | |
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Symbol | GABRA3 |
Name | gamma-aminobutyric acid (GABA) A receptor, alpha 3 |
Aliases | GABA(A) receptor, alpha 3; GABA(A) receptor subunit alpha-3; gamma-animobutyric acid (GABA) A receptor, alph ...... |
Chromosomal Location | Xq28 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. |
Domain |
PF02931 Neurotransmitter-gated ion-channel ligand binding domain PF02932 Neurotransmitter-gated ion-channel transmembrane region |
Function |
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. |
Biological Process |
GO:0006820 anion transport GO:0006821 chloride transport GO:0007214 gamma-aminobutyric acid signaling pathway GO:0015698 inorganic anion transport GO:0098656 anion transmembrane transport GO:0098661 inorganic anion transmembrane transport GO:1902476 chloride transmembrane transport |
Molecular Function |
GO:0004890 GABA-A receptor activity GO:0005216 ion channel activity GO:0005230 extracellular ligand-gated ion channel activity GO:0005253 anion channel activity GO:0005254 chloride channel activity GO:0008503 benzodiazepine receptor activity GO:0008509 anion transmembrane transporter activity GO:0015103 inorganic anion transmembrane transporter activity GO:0015108 chloride transmembrane transporter activity GO:0015267 channel activity GO:0015276 ligand-gated ion channel activity GO:0016917 GABA receptor activity GO:0022803 passive transmembrane transporter activity GO:0022834 ligand-gated channel activity GO:0022836 gated channel activity GO:0022838 substrate-specific channel activity GO:0030594 neurotransmitter receptor activity |
Cellular Component |
GO:0034702 ion channel complex GO:0034707 chloride channel complex GO:0043235 receptor complex GO:0045211 postsynaptic membrane GO:0097060 synaptic membrane GO:0098794 postsynapse GO:1902495 transmembrane transporter complex GO:1902710 GABA receptor complex GO:1902711 GABA-A receptor complex GO:1990351 transporter complex |
KEGG |
hsa04080 Neuroactive ligand-receptor interaction hsa04723 Retrograde endocannabinoid signaling hsa04727 GABAergic synapse hsa04742 Taste transduction |
Reactome |
R-HSA-977441: GABA A receptor activation R-HSA-977443: GABA receptor activation R-HSA-983712: Ion channel transport R-HSA-975298: Ligand-gated ion channel transport R-HSA-112316: Neuronal System R-HSA-112314: Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell R-HSA-382551: Transmembrane transport of small molecules R-HSA-112315: Transmission across Chemical Synapses |
Summary | |
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Symbol | GABRA3 |
Name | gamma-aminobutyric acid (GABA) A receptor, alpha 3 |
Aliases | GABA(A) receptor, alpha 3; GABA(A) receptor subunit alpha-3; gamma-animobutyric acid (GABA) A receptor, alph ...... |
Chromosomal Location | Xq28 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between GABRA3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | GABRA3 |
Name | gamma-aminobutyric acid (GABA) A receptor, alpha 3 |
Aliases | GABA(A) receptor, alpha 3; GABA(A) receptor subunit alpha-3; gamma-animobutyric acid (GABA) A receptor, alph ...... |
Chromosomal Location | Xq28 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of GABRA3 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | GABRA3 |
Name | gamma-aminobutyric acid (GABA) A receptor, alpha 3 |
Aliases | GABA(A) receptor, alpha 3; GABA(A) receptor subunit alpha-3; gamma-animobutyric acid (GABA) A receptor, alph ...... |
Chromosomal Location | Xq28 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of GABRA3 in various data sets.
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Points in the above scatter plot represent the mutation difference of GABRA3 in various data sets.
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Summary | |
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Symbol | GABRA3 |
Name | gamma-aminobutyric acid (GABA) A receptor, alpha 3 |
Aliases | GABA(A) receptor, alpha 3; GABA(A) receptor subunit alpha-3; gamma-animobutyric acid (GABA) A receptor, alph ...... |
Chromosomal Location | Xq28 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GABRA3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | GABRA3 |
Name | gamma-aminobutyric acid (GABA) A receptor, alpha 3 |
Aliases | GABA(A) receptor, alpha 3; GABA(A) receptor subunit alpha-3; gamma-animobutyric acid (GABA) A receptor, alph ...... |
Chromosomal Location | Xq28 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GABRA3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GABRA3. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | GABRA3 |
Name | gamma-aminobutyric acid (GABA) A receptor, alpha 3 |
Aliases | GABA(A) receptor, alpha 3; GABA(A) receptor subunit alpha-3; gamma-animobutyric acid (GABA) A receptor, alph ...... |
Chromosomal Location | Xq28 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GABRA3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | GABRA3 |
Name | gamma-aminobutyric acid (GABA) A receptor, alpha 3 |
Aliases | GABA(A) receptor, alpha 3; GABA(A) receptor subunit alpha-3; gamma-animobutyric acid (GABA) A receptor, alph ...... |
Chromosomal Location | Xq28 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of GABRA3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | GABRA3 |
Name | gamma-aminobutyric acid (GABA) A receptor, alpha 3 |
Aliases | GABA(A) receptor, alpha 3; GABA(A) receptor subunit alpha-3; gamma-animobutyric acid (GABA) A receptor, alph ...... |
Chromosomal Location | Xq28 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between GABRA3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | GABRA3 |
Name | gamma-aminobutyric acid (GABA) A receptor, alpha 3 |
Aliases | GABA(A) receptor, alpha 3; GABA(A) receptor subunit alpha-3; gamma-animobutyric acid (GABA) A receptor, alph ...... |
Chromosomal Location | Xq28 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting GABRA3 collected from DrugBank database. |
Details on drugs targeting GABRA3.
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