Browse GADD45G

Summary
SymbolGADD45G
Namegrowth arrest and DNA-damage-inducible, gamma
Aliases DDIT2; GADD45gamma; GRP17; CR6; gadd-related protein, 17 kD; growth arrest and DNA-damage-inducible gamma; D ......
Chromosomal Location9q22.1-q22.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location -
Domain PF01248 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
Function

Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK.

> Gene Ontology
 
Biological Process GO:0000185 activation of MAPKKK activity
GO:0007254 JNK cascade
GO:0031098 stress-activated protein kinase signaling cascade
GO:0032147 activation of protein kinase activity
GO:0032872 regulation of stress-activated MAPK cascade
GO:0032874 positive regulation of stress-activated MAPK cascade
GO:0033674 positive regulation of kinase activity
GO:0038066 p38MAPK cascade
GO:0043405 regulation of MAP kinase activity
GO:0043410 positive regulation of MAPK cascade
GO:0045860 positive regulation of protein kinase activity
GO:0046328 regulation of JNK cascade
GO:0046330 positive regulation of JNK cascade
GO:0051403 stress-activated MAPK cascade
GO:0070302 regulation of stress-activated protein kinase signaling cascade
GO:0070304 positive regulation of stress-activated protein kinase signaling cascade
GO:0071900 regulation of protein serine/threonine kinase activity
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:1900744 regulation of p38MAPK cascade
GO:1900745 positive regulation of p38MAPK cascade
Molecular Function -
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa04010 MAPK signaling pathway
hsa04068 FoxO signaling pathway
hsa04110 Cell cycle
hsa04115 p53 signaling pathway
hsa04210 Apoptosis
Reactome -
Summary
SymbolGADD45G
Namegrowth arrest and DNA-damage-inducible, gamma
Aliases DDIT2; GADD45gamma; GRP17; CR6; gadd-related protein, 17 kD; growth arrest and DNA-damage-inducible gamma; D ......
Chromosomal Location9q22.1-q22.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between GADD45G and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between GADD45G and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
19688743MelanomaPromote immunity (T cell function)Gadd45b and Gadd45g are important for anti-tumor immune responses.
Summary
SymbolGADD45G
Namegrowth arrest and DNA-damage-inducible, gamma
Aliases DDIT2; GADD45gamma; GRP17; CR6; gadd-related protein, 17 kD; growth arrest and DNA-damage-inducible gamma; D ......
Chromosomal Location9q22.1-q22.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of GADD45G in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolGADD45G
Namegrowth arrest and DNA-damage-inducible, gamma
Aliases DDIT2; GADD45gamma; GRP17; CR6; gadd-related protein, 17 kD; growth arrest and DNA-damage-inducible gamma; D ......
Chromosomal Location9q22.1-q22.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of GADD45G in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.1430.8
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.5950.653
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.1890.855
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.1870.684
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.2620.805
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.7560.555
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.1930.749
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.6920.44
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.4930.593
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.5010.652
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.6310.678
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.1060.537
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of GADD45G in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27730001
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolGADD45G
Namegrowth arrest and DNA-damage-inducible, gamma
Aliases DDIT2; GADD45gamma; GRP17; CR6; gadd-related protein, 17 kD; growth arrest and DNA-damage-inducible gamma; D ......
Chromosomal Location9q22.1-q22.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GADD45G. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolGADD45G
Namegrowth arrest and DNA-damage-inducible, gamma
Aliases DDIT2; GADD45gamma; GRP17; CR6; gadd-related protein, 17 kD; growth arrest and DNA-damage-inducible gamma; D ......
Chromosomal Location9q22.1-q22.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GADD45G. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GADD45G.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolGADD45G
Namegrowth arrest and DNA-damage-inducible, gamma
Aliases DDIT2; GADD45gamma; GRP17; CR6; gadd-related protein, 17 kD; growth arrest and DNA-damage-inducible gamma; D ......
Chromosomal Location9q22.1-q22.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GADD45G. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolGADD45G
Namegrowth arrest and DNA-damage-inducible, gamma
Aliases DDIT2; GADD45gamma; GRP17; CR6; gadd-related protein, 17 kD; growth arrest and DNA-damage-inducible gamma; D ......
Chromosomal Location9q22.1-q22.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of GADD45G expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolGADD45G
Namegrowth arrest and DNA-damage-inducible, gamma
Aliases DDIT2; GADD45gamma; GRP17; CR6; gadd-related protein, 17 kD; growth arrest and DNA-damage-inducible gamma; D ......
Chromosomal Location9q22.1-q22.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between GADD45G and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolGADD45G
Namegrowth arrest and DNA-damage-inducible, gamma
Aliases DDIT2; GADD45gamma; GRP17; CR6; gadd-related protein, 17 kD; growth arrest and DNA-damage-inducible gamma; D ......
Chromosomal Location9q22.1-q22.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting GADD45G collected from DrugBank database.
> Drugs from DrugBank database
 

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