Summary | |
---|---|
Symbol | GAK |
Name | cyclin G associated kinase |
Aliases | DNAJC26; auxilin-2; DNAJ26; Cyclin-G-associated kinase |
Chromosomal Location | 4p16 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm, perinuclear region Golgi apparatus, trans-Golgi network Cell junction, focal adhesion Note=Localizes to the perinuclear area and to the trans-Golgi network. Also seen on the plasma membrane, probably at focal adhesions. |
Domain |
PF00069 Protein kinase domain PF10409 C2 domain of PTEN tumour-suppressor protein |
Function |
Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1. |
Biological Process |
GO:0006892 post-Golgi vesicle-mediated transport GO:0006896 Golgi to vacuole transport GO:0006898 receptor-mediated endocytosis GO:0007009 plasma membrane organization GO:0007029 endoplasmic reticulum organization GO:0007030 Golgi organization GO:0007034 vacuolar transport GO:0007041 lysosomal transport GO:0010721 negative regulation of cell development GO:0010975 regulation of neuron projection development GO:0010977 negative regulation of neuron projection development GO:0016482 cytosolic transport GO:0031345 negative regulation of cell projection organization GO:0032984 macromolecular complex disassembly GO:0034067 protein localization to Golgi apparatus GO:0043241 protein complex disassembly GO:0043624 cellular protein complex disassembly GO:0045665 negative regulation of neuron differentiation GO:0048193 Golgi vesicle transport GO:0050768 negative regulation of neurogenesis GO:0051261 protein depolymerization GO:0051961 negative regulation of nervous system development GO:0072318 clathrin coat disassembly GO:0072319 vesicle uncoating GO:0072583 clathrin-dependent endocytosis GO:0072600 establishment of protein localization to Golgi GO:0072657 protein localization to membrane GO:0072659 protein localization to plasma membrane GO:0090002 establishment of protein localization to plasma membrane GO:0090150 establishment of protein localization to membrane GO:0090160 Golgi to lysosome transport GO:1990778 protein localization to cell periphery |
Molecular Function |
GO:0004674 protein serine/threonine kinase activity GO:0030332 cyclin binding |
Cellular Component |
GO:0005924 cell-substrate adherens junction GO:0005925 focal adhesion GO:0030055 cell-substrate junction |
KEGG | - |
Reactome |
R-HSA-421837: Clathrin derived vesicle budding R-HSA-8856828: Clathrin-mediated endocytosis R-HSA-432722: Golgi Associated Vesicle Biogenesis R-HSA-199991: Membrane Trafficking R-HSA-5653656: Vesicle-mediated transport R-HSA-199992: trans-Golgi Network Vesicle Budding |
Summary | |
---|---|
Symbol | GAK |
Name | cyclin G associated kinase |
Aliases | DNAJC26; auxilin-2; DNAJ26; Cyclin-G-associated kinase |
Chromosomal Location | 4p16 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between GAK and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | GAK |
Name | cyclin G associated kinase |
Aliases | DNAJC26; auxilin-2; DNAJ26; Cyclin-G-associated kinase |
Chromosomal Location | 4p16 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of GAK in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | GAK |
Name | cyclin G associated kinase |
Aliases | DNAJC26; auxilin-2; DNAJ26; Cyclin-G-associated kinase |
Chromosomal Location | 4p16 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of GAK in various data sets.
|
Points in the above scatter plot represent the mutation difference of GAK in various data sets.
|
Summary | |
---|---|
Symbol | GAK |
Name | cyclin G associated kinase |
Aliases | DNAJC26; auxilin-2; DNAJ26; Cyclin-G-associated kinase |
Chromosomal Location | 4p16 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GAK. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | GAK |
Name | cyclin G associated kinase |
Aliases | DNAJC26; auxilin-2; DNAJ26; Cyclin-G-associated kinase |
Chromosomal Location | 4p16 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GAK. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GAK. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | GAK |
Name | cyclin G associated kinase |
Aliases | DNAJC26; auxilin-2; DNAJ26; Cyclin-G-associated kinase |
Chromosomal Location | 4p16 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GAK. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | GAK |
Name | cyclin G associated kinase |
Aliases | DNAJC26; auxilin-2; DNAJ26; Cyclin-G-associated kinase |
Chromosomal Location | 4p16 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of GAK expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | GAK |
Name | cyclin G associated kinase |
Aliases | DNAJC26; auxilin-2; DNAJ26; Cyclin-G-associated kinase |
Chromosomal Location | 4p16 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between GAK and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |