Summary | |
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Symbol | GALE |
Name | UDP-galactose-4-epimerase |
Aliases | SDR1E1; short chain dehydrogenase/reductase family 1E, member 1; UDP-glucose 4-epimerase; galactose-4-epimer ...... |
Chromosomal Location | 1p36-p35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | - |
Domain |
PF16363 GDP-mannose 4 |
Function |
Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids. |
Biological Process |
GO:0005996 monosaccharide metabolic process GO:0006012 galactose metabolic process GO:0016052 carbohydrate catabolic process GO:0019318 hexose metabolic process GO:0019320 hexose catabolic process GO:0019388 galactose catabolic process GO:0044282 small molecule catabolic process GO:0044723 single-organism carbohydrate metabolic process GO:0044724 single-organism carbohydrate catabolic process GO:0046365 monosaccharide catabolic process |
Molecular Function |
GO:0003974 UDP-N-acetylglucosamine 4-epimerase activity GO:0003978 UDP-glucose 4-epimerase activity GO:0016853 isomerase activity GO:0016854 racemase and epimerase activity GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives |
Cellular Component | - |
KEGG |
hsa00052 Galactose metabolism hsa00520 Amino sugar and nucleotide sugar metabolism hsa01100 Metabolic pathways |
Reactome |
R-HSA-70370: Galactose catabolism R-HSA-1430728: Metabolism R-HSA-71387: Metabolism of carbohydrates |
Summary | |
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Symbol | GALE |
Name | UDP-galactose-4-epimerase |
Aliases | SDR1E1; short chain dehydrogenase/reductase family 1E, member 1; UDP-glucose 4-epimerase; galactose-4-epimer ...... |
Chromosomal Location | 1p36-p35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between GALE and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | GALE |
Name | UDP-galactose-4-epimerase |
Aliases | SDR1E1; short chain dehydrogenase/reductase family 1E, member 1; UDP-glucose 4-epimerase; galactose-4-epimer ...... |
Chromosomal Location | 1p36-p35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of GALE in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | GALE |
Name | UDP-galactose-4-epimerase |
Aliases | SDR1E1; short chain dehydrogenase/reductase family 1E, member 1; UDP-glucose 4-epimerase; galactose-4-epimer ...... |
Chromosomal Location | 1p36-p35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of GALE in various data sets.
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There is no record. |
Summary | |
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Symbol | GALE |
Name | UDP-galactose-4-epimerase |
Aliases | SDR1E1; short chain dehydrogenase/reductase family 1E, member 1; UDP-glucose 4-epimerase; galactose-4-epimer ...... |
Chromosomal Location | 1p36-p35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GALE. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | GALE |
Name | UDP-galactose-4-epimerase |
Aliases | SDR1E1; short chain dehydrogenase/reductase family 1E, member 1; UDP-glucose 4-epimerase; galactose-4-epimer ...... |
Chromosomal Location | 1p36-p35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GALE. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GALE. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | GALE |
Name | UDP-galactose-4-epimerase |
Aliases | SDR1E1; short chain dehydrogenase/reductase family 1E, member 1; UDP-glucose 4-epimerase; galactose-4-epimer ...... |
Chromosomal Location | 1p36-p35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GALE. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | GALE |
Name | UDP-galactose-4-epimerase |
Aliases | SDR1E1; short chain dehydrogenase/reductase family 1E, member 1; UDP-glucose 4-epimerase; galactose-4-epimer ...... |
Chromosomal Location | 1p36-p35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of GALE expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | GALE |
Name | UDP-galactose-4-epimerase |
Aliases | SDR1E1; short chain dehydrogenase/reductase family 1E, member 1; UDP-glucose 4-epimerase; galactose-4-epimer ...... |
Chromosomal Location | 1p36-p35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between GALE and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | GALE |
Name | UDP-galactose-4-epimerase |
Aliases | SDR1E1; short chain dehydrogenase/reductase family 1E, member 1; UDP-glucose 4-epimerase; galactose-4-epimer ...... |
Chromosomal Location | 1p36-p35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting GALE collected from DrugBank database. |
Details on drugs targeting GALE.
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