Summary | |
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Symbol | GANC |
Name | glucosidase, alpha; neutral C |
Aliases | Neutral alpha-glucosidase C |
Chromosomal Location | 15q15.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | - |
Domain |
PF13802 Galactose mutarotase-like PF01055 Glycosyl hydrolases family 31 |
Function |
Has alpha-glucosidase activity. |
Biological Process |
GO:0000023 maltose metabolic process GO:0005984 disaccharide metabolic process GO:0009311 oligosaccharide metabolic process GO:0044262 cellular carbohydrate metabolic process GO:0044723 single-organism carbohydrate metabolic process |
Molecular Function |
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GO:0004558 alpha-1,4-glucosidase activity GO:0015926 glucosidase activity GO:0016798 hydrolase activity, acting on glycosyl bonds GO:0030246 carbohydrate binding GO:0032450 maltose alpha-glucosidase activity GO:0090599 alpha-glucosidase activity |
Cellular Component | - |
KEGG |
hsa00052 Galactose metabolism hsa00500 Starch and sucrose metabolism hsa01100 Metabolic pathways |
Reactome | - |
Summary | |
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Symbol | GANC |
Name | glucosidase, alpha; neutral C |
Aliases | Neutral alpha-glucosidase C |
Chromosomal Location | 15q15.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between GANC and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | GANC |
Name | glucosidase, alpha; neutral C |
Aliases | Neutral alpha-glucosidase C |
Chromosomal Location | 15q15.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of GANC in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | GANC |
Name | glucosidase, alpha; neutral C |
Aliases | Neutral alpha-glucosidase C |
Chromosomal Location | 15q15.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of GANC in various data sets.
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Points in the above scatter plot represent the mutation difference of GANC in various data sets.
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Summary | |
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Symbol | GANC |
Name | glucosidase, alpha; neutral C |
Aliases | Neutral alpha-glucosidase C |
Chromosomal Location | 15q15.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GANC. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | GANC |
Name | glucosidase, alpha; neutral C |
Aliases | Neutral alpha-glucosidase C |
Chromosomal Location | 15q15.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GANC. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GANC. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | GANC |
Name | glucosidase, alpha; neutral C |
Aliases | Neutral alpha-glucosidase C |
Chromosomal Location | 15q15.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GANC. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | GANC |
Name | glucosidase, alpha; neutral C |
Aliases | Neutral alpha-glucosidase C |
Chromosomal Location | 15q15.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of GANC expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | GANC |
Name | glucosidase, alpha; neutral C |
Aliases | Neutral alpha-glucosidase C |
Chromosomal Location | 15q15.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between GANC and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | GANC |
Name | glucosidase, alpha; neutral C |
Aliases | Neutral alpha-glucosidase C |
Chromosomal Location | 15q15.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting GANC collected from DrugBank database. |
Details on drugs targeting GANC.
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