Summary | |
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Symbol | GCH1 |
Name | GTP cyclohydrolase 1 |
Aliases | GTPCH1; DYT5a; dopa-responsive dystonia; GCH; DYT5; GTP-CH-1; HPABH4B; GTP-CH-I; guanosine 5'-triphosphate c ...... |
Chromosomal Location | 14q22.1-q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Nucleus |
Domain |
PF01227 GTP cyclohydrolase I |
Function |
Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown. |
Biological Process |
GO:0000302 response to reactive oxygen species GO:0000303 response to superoxide GO:0000305 response to oxygen radical GO:0002237 response to molecule of bacterial origin GO:0003013 circulatory system process GO:0003018 vascular process in circulatory system GO:0006575 cellular modified amino acid metabolic process GO:0006584 catecholamine metabolic process GO:0006729 tetrahydrobiopterin biosynthetic process GO:0006732 coenzyme metabolic process GO:0006760 folic acid-containing compound metabolic process GO:0006801 superoxide metabolic process GO:0006809 nitric oxide biosynthetic process GO:0006979 response to oxidative stress GO:0008015 blood circulation GO:0008217 regulation of blood pressure GO:0009108 coenzyme biosynthetic process GO:0009396 folic acid-containing compound biosynthetic process GO:0009636 response to toxic substance GO:0009712 catechol-containing compound metabolic process GO:0009713 catechol-containing compound biosynthetic process GO:0010035 response to inorganic substance GO:0014916 regulation of lung blood pressure GO:0018958 phenol-containing compound metabolic process GO:0019430 removal of superoxide radicals GO:0032496 response to lipopolysaccharide GO:0032768 regulation of monooxygenase activity GO:0032770 positive regulation of monooxygenase activity GO:0033555 multicellular organismal response to stress GO:0034341 response to interferon-gamma GO:0034599 cellular response to oxidative stress GO:0034612 response to tumor necrosis factor GO:0034614 cellular response to reactive oxygen species GO:0035150 regulation of tube size GO:0035998 7,8-dihydroneopterin 3'-triphosphate biosynthetic process GO:0042311 vasodilation GO:0042398 cellular modified amino acid biosynthetic process GO:0042416 dopamine biosynthetic process GO:0042417 dopamine metabolic process GO:0042423 catecholamine biosynthetic process GO:0042558 pteridine-containing compound metabolic process GO:0042559 pteridine-containing compound biosynthetic process GO:0045776 negative regulation of blood pressure GO:0046146 tetrahydrobiopterin metabolic process GO:0046189 phenol-containing compound biosynthetic process GO:0046209 nitric oxide metabolic process GO:0046653 tetrahydrofolate metabolic process GO:0046654 tetrahydrofolate biosynthetic process GO:0048265 response to pain GO:0050880 regulation of blood vessel size GO:0050884 neuromuscular process controlling posture GO:0050905 neuromuscular process GO:0050999 regulation of nitric-oxide synthase activity GO:0051000 positive regulation of nitric-oxide synthase activity GO:0051066 dihydrobiopterin metabolic process GO:0051186 cofactor metabolic process GO:0051188 cofactor biosynthetic process GO:0051259 protein oligomerization GO:0051260 protein homooligomerization GO:0051291 protein heterooligomerization GO:0051341 regulation of oxidoreductase activity GO:0051353 positive regulation of oxidoreductase activity GO:0071450 cellular response to oxygen radical GO:0071451 cellular response to superoxide GO:0072593 reactive oxygen species metabolic process GO:0090066 regulation of anatomical structure size GO:0090322 regulation of superoxide metabolic process GO:0098754 detoxification GO:0098869 cellular oxidant detoxification GO:1900407 regulation of cellular response to oxidative stress GO:1901031 regulation of response to reactive oxygen species GO:1901615 organic hydroxy compound metabolic process GO:1901617 organic hydroxy compound biosynthetic process GO:1902882 regulation of response to oxidative stress GO:1903409 reactive oxygen species biosynthetic process GO:1990748 cellular detoxification GO:2000121 regulation of removal of superoxide radicals GO:2000377 regulation of reactive oxygen species metabolic process GO:2001057 reactive nitrogen species metabolic process |
Molecular Function |
GO:0003933 GTP cyclohydrolase activity GO:0003934 GTP cyclohydrolase I activity GO:0005525 GTP binding GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines GO:0019001 guanyl nucleotide binding GO:0019238 cyclohydrolase activity GO:0030742 GTP-dependent protein binding GO:0031369 translation initiation factor binding GO:0032561 guanyl ribonucleotide binding GO:0048037 cofactor binding GO:0050662 coenzyme binding |
Cellular Component |
GO:0005635 nuclear envelope GO:0031965 nuclear membrane |
KEGG |
hsa00790 Folate biosynthesis hsa01100 Metabolic pathways |
Reactome |
R-HSA-1430728: Metabolism R-HSA-202131: Metabolism of nitric oxide R-HSA-1474151: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-203765: eNOS activation and regulation |
Summary | |
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Symbol | GCH1 |
Name | GTP cyclohydrolase 1 |
Aliases | GTPCH1; DYT5a; dopa-responsive dystonia; GCH; DYT5; GTP-CH-1; HPABH4B; GTP-CH-I; guanosine 5'-triphosphate c ...... |
Chromosomal Location | 14q22.1-q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between GCH1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between GCH1 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | GCH1 |
Name | GTP cyclohydrolase 1 |
Aliases | GTPCH1; DYT5a; dopa-responsive dystonia; GCH; DYT5; GTP-CH-1; HPABH4B; GTP-CH-I; guanosine 5'-triphosphate c ...... |
Chromosomal Location | 14q22.1-q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of GCH1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | GCH1 |
Name | GTP cyclohydrolase 1 |
Aliases | GTPCH1; DYT5a; dopa-responsive dystonia; GCH; DYT5; GTP-CH-1; HPABH4B; GTP-CH-I; guanosine 5'-triphosphate c ...... |
Chromosomal Location | 14q22.1-q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of GCH1 in various data sets.
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Points in the above scatter plot represent the mutation difference of GCH1 in various data sets.
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Summary | |
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Symbol | GCH1 |
Name | GTP cyclohydrolase 1 |
Aliases | GTPCH1; DYT5a; dopa-responsive dystonia; GCH; DYT5; GTP-CH-1; HPABH4B; GTP-CH-I; guanosine 5'-triphosphate c ...... |
Chromosomal Location | 14q22.1-q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GCH1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | GCH1 |
Name | GTP cyclohydrolase 1 |
Aliases | GTPCH1; DYT5a; dopa-responsive dystonia; GCH; DYT5; GTP-CH-1; HPABH4B; GTP-CH-I; guanosine 5'-triphosphate c ...... |
Chromosomal Location | 14q22.1-q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GCH1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GCH1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | GCH1 |
Name | GTP cyclohydrolase 1 |
Aliases | GTPCH1; DYT5a; dopa-responsive dystonia; GCH; DYT5; GTP-CH-1; HPABH4B; GTP-CH-I; guanosine 5'-triphosphate c ...... |
Chromosomal Location | 14q22.1-q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GCH1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | GCH1 |
Name | GTP cyclohydrolase 1 |
Aliases | GTPCH1; DYT5a; dopa-responsive dystonia; GCH; DYT5; GTP-CH-1; HPABH4B; GTP-CH-I; guanosine 5'-triphosphate c ...... |
Chromosomal Location | 14q22.1-q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of GCH1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | GCH1 |
Name | GTP cyclohydrolase 1 |
Aliases | GTPCH1; DYT5a; dopa-responsive dystonia; GCH; DYT5; GTP-CH-1; HPABH4B; GTP-CH-I; guanosine 5'-triphosphate c ...... |
Chromosomal Location | 14q22.1-q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between GCH1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | GCH1 |
Name | GTP cyclohydrolase 1 |
Aliases | GTPCH1; DYT5a; dopa-responsive dystonia; GCH; DYT5; GTP-CH-1; HPABH4B; GTP-CH-I; guanosine 5'-triphosphate c ...... |
Chromosomal Location | 14q22.1-q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting GCH1 collected from DrugBank database. |
Details on drugs targeting GCH1.
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