Browse GCK

Summary
SymbolGCK
Nameglucokinase (hexokinase 4)
Aliases MODY2; maturity onset diabetes of the young 2; FGQTL3; HHF3; HKIV; HXKP; LGLK; HK IV; hexokinase D, pancreat ......
Chromosomal Location7p15.3-p15.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm Nucleus Note=Under low glucose concentrations, GCK associates with GKRP and the inactive complex is recruited to the hepatocyte nucleus.
Domain PF00349 Hexokinase
PF03727 Hexokinase
Function

Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage.

> Gene Ontology
 
Biological Process GO:0000271 polysaccharide biosynthetic process
GO:0001678 cellular glucose homeostasis
GO:0002790 peptide secretion
GO:0002791 regulation of peptide secretion
GO:0002793 positive regulation of peptide secretion
GO:0005976 polysaccharide metabolic process
GO:0005977 glycogen metabolic process
GO:0005978 glycogen biosynthetic process
GO:0005979 regulation of glycogen biosynthetic process
GO:0005996 monosaccharide metabolic process
GO:0006006 glucose metabolic process
GO:0006007 glucose catabolic process
GO:0006073 cellular glucan metabolic process
GO:0006090 pyruvate metabolic process
GO:0006091 generation of precursor metabolites and energy
GO:0006094 gluconeogenesis
GO:0006096 glycolytic process
GO:0006109 regulation of carbohydrate metabolic process
GO:0006110 regulation of glycolytic process
GO:0006111 regulation of gluconeogenesis
GO:0006112 energy reserve metabolic process
GO:0006140 regulation of nucleotide metabolic process
GO:0006165 nucleoside diphosphate phosphorylation
GO:0006732 coenzyme metabolic process
GO:0006733 oxidoreduction coenzyme metabolic process
GO:0006734 NADH metabolic process
GO:0006735 NADH regeneration
GO:0006739 NADP metabolic process
GO:0006757 ATP generation from ADP
GO:0006813 potassium ion transport
GO:0006816 calcium ion transport
GO:0008643 carbohydrate transport
GO:0008645 hexose transport
GO:0009116 nucleoside metabolic process
GO:0009118 regulation of nucleoside metabolic process
GO:0009119 ribonucleoside metabolic process
GO:0009123 nucleoside monophosphate metabolic process
GO:0009126 purine nucleoside monophosphate metabolic process
GO:0009132 nucleoside diphosphate metabolic process
GO:0009135 purine nucleoside diphosphate metabolic process
GO:0009141 nucleoside triphosphate metabolic process
GO:0009144 purine nucleoside triphosphate metabolic process
GO:0009150 purine ribonucleotide metabolic process
GO:0009161 ribonucleoside monophosphate metabolic process
GO:0009167 purine ribonucleoside monophosphate metabolic process
GO:0009179 purine ribonucleoside diphosphate metabolic process
GO:0009185 ribonucleoside diphosphate metabolic process
GO:0009199 ribonucleoside triphosphate metabolic process
GO:0009205 purine ribonucleoside triphosphate metabolic process
GO:0009250 glucan biosynthetic process
GO:0009306 protein secretion
GO:0009730 detection of carbohydrate stimulus
GO:0009732 detection of hexose stimulus
GO:0009743 response to carbohydrate
GO:0009746 response to hexose
GO:0009749 response to glucose
GO:0009894 regulation of catabolic process
GO:0009914 hormone transport
GO:0010675 regulation of cellular carbohydrate metabolic process
GO:0010676 positive regulation of cellular carbohydrate metabolic process
GO:0010677 negative regulation of cellular carbohydrate metabolic process
GO:0010817 regulation of hormone levels
GO:0010827 regulation of glucose transport
GO:0010906 regulation of glucose metabolic process
GO:0010907 positive regulation of glucose metabolic process
GO:0010959 regulation of metal ion transport
GO:0010962 regulation of glucan biosynthetic process
GO:0015672 monovalent inorganic cation transport
GO:0015749 monosaccharide transport
GO:0015758 glucose transport
GO:0015833 peptide transport
GO:0015980 energy derivation by oxidation of organic compounds
GO:0016051 carbohydrate biosynthetic process
GO:0016052 carbohydrate catabolic process
GO:0019318 hexose metabolic process
GO:0019319 hexose biosynthetic process
GO:0019320 hexose catabolic process
GO:0019362 pyridine nucleotide metabolic process
GO:0019674 NAD metabolic process
GO:0023061 signal release
GO:0030072 peptide hormone secretion
GO:0030073 insulin secretion
GO:0032024 positive regulation of insulin secretion
GO:0032868 response to insulin
GO:0032869 cellular response to insulin stimulus
GO:0032881 regulation of polysaccharide metabolic process
GO:0032885 regulation of polysaccharide biosynthetic process
GO:0033500 carbohydrate homeostasis
GO:0033692 cellular polysaccharide biosynthetic process
GO:0034284 response to monosaccharide
GO:0034287 detection of monosaccharide stimulus
GO:0034637 cellular carbohydrate biosynthetic process
GO:0042278 purine nucleoside metabolic process
GO:0042593 glucose homeostasis
GO:0042886 amide transport
GO:0043255 regulation of carbohydrate biosynthetic process
GO:0043266 regulation of potassium ion transport
GO:0043434 response to peptide hormone
GO:0043467 regulation of generation of precursor metabolites and energy
GO:0043470 regulation of carbohydrate catabolic process
GO:0044042 glucan metabolic process
GO:0044262 cellular carbohydrate metabolic process
GO:0044264 cellular polysaccharide metabolic process
GO:0044282 small molecule catabolic process
GO:0044283 small molecule biosynthetic process
GO:0044320 cellular response to leptin stimulus
GO:0044321 response to leptin
GO:0044723 single-organism carbohydrate metabolic process
GO:0044724 single-organism carbohydrate catabolic process
GO:0045721 negative regulation of gluconeogenesis
GO:0045725 positive regulation of glycogen biosynthetic process
GO:0045912 negative regulation of carbohydrate metabolic process
GO:0045913 positive regulation of carbohydrate metabolic process
GO:0046031 ADP metabolic process
GO:0046034 ATP metabolic process
GO:0046128 purine ribonucleoside metabolic process
GO:0046364 monosaccharide biosynthetic process
GO:0046365 monosaccharide catabolic process
GO:0046496 nicotinamide nucleotide metabolic process
GO:0046835 carbohydrate phosphorylation
GO:0046879 hormone secretion
GO:0046883 regulation of hormone secretion
GO:0046887 positive regulation of hormone secretion
GO:0046939 nucleotide phosphorylation
GO:0050708 regulation of protein secretion
GO:0050714 positive regulation of protein secretion
GO:0050796 regulation of insulin secretion
GO:0051047 positive regulation of secretion
GO:0051156 glucose 6-phosphate metabolic process
GO:0051186 cofactor metabolic process
GO:0051193 regulation of cofactor metabolic process
GO:0051196 regulation of coenzyme metabolic process
GO:0051222 positive regulation of protein transport
GO:0051594 detection of glucose
GO:0061615 glycolytic process through fructose-6-phosphate
GO:0061620 glycolytic process through glucose-6-phosphate
GO:0061621 canonical glycolysis
GO:0061718 glucose catabolic process to pyruvate
GO:0070509 calcium ion import
GO:0070838 divalent metal ion transport
GO:0070873 regulation of glycogen metabolic process
GO:0070875 positive regulation of glycogen metabolic process
GO:0071375 cellular response to peptide hormone stimulus
GO:0071417 cellular response to organonitrogen compound
GO:0072511 divalent inorganic cation transport
GO:0072524 pyridine-containing compound metabolic process
GO:0090087 regulation of peptide transport
GO:0090276 regulation of peptide hormone secretion
GO:0090277 positive regulation of peptide hormone secretion
GO:1900542 regulation of purine nucleotide metabolic process
GO:1901652 response to peptide
GO:1901653 cellular response to peptide
GO:1901657 glycosyl compound metabolic process
GO:1903532 positive regulation of secretion by cell
GO:1903578 regulation of ATP metabolic process
GO:1904951 positive regulation of establishment of protein localization
Molecular Function GO:0004340 glucokinase activity
GO:0004396 hexokinase activity
GO:0005536 glucose binding
GO:0019200 carbohydrate kinase activity
GO:0030246 carbohydrate binding
GO:0048029 monosaccharide binding
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa04910 Insulin signaling pathway
hsa04911 Insulin secretion
hsa04917 Prolactin signaling pathway
hsa04922 Glucagon signaling pathway
hsa00010 Glycolysis / Gluconeogenesis
hsa00052 Galactose metabolism
hsa00500 Starch and sucrose metabolism
hsa00520 Amino sugar and nucleotide sugar metabolism
hsa00524 Butirosin and neomycin biosynthesis
hsa01100 Metabolic pathways
hsa01200 Carbon metabolism
Reactome R-HSA-5619107: Defective TRP may confer susceptibility towards thyroid papillary carcinoma (TPC)
R-HSA-1266738: Developmental Biology
R-HSA-1643685: Disease
R-HSA-5619115: Disorders of transmembrane transporters
R-HSA-70326: Glucose metabolism
R-HSA-70153: Glucose transport
R-HSA-70171: Glycolysis
R-HSA-189200: Hexose transport
R-HSA-1430728: Metabolism
R-HSA-71387: Metabolism of carbohydrates
R-HSA-170822: Regulation of Glucokinase by Glucokinase Regulatory Protein
R-HSA-186712: Regulation of beta-cell development
R-HSA-210745: Regulation of gene expression in beta cells
R-HSA-5619102: SLC transporter disorders
R-HSA-425407: SLC-mediated transmembrane transport
R-HSA-382551: Transmembrane transport of small molecules
Summary
SymbolGCK
Nameglucokinase (hexokinase 4)
Aliases MODY2; maturity onset diabetes of the young 2; FGQTL3; HHF3; HKIV; HXKP; LGLK; HK IV; hexokinase D, pancreat ......
Chromosomal Location7p15.3-p15.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between GCK and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolGCK
Nameglucokinase (hexokinase 4)
Aliases MODY2; maturity onset diabetes of the young 2; FGQTL3; HHF3; HKIV; HXKP; LGLK; HK IV; hexokinase D, pancreat ......
Chromosomal Location7p15.3-p15.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of GCK in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolGCK
Nameglucokinase (hexokinase 4)
Aliases MODY2; maturity onset diabetes of the young 2; FGQTL3; HHF3; HKIV; HXKP; LGLK; HK IV; hexokinase D, pancreat ......
Chromosomal Location7p15.3-p15.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of GCK in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.7510.0364
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-1.6550.00867
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.1010.847
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.1530.869
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.4840.719
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.9490.528
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0050.994
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.2060.881
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.1220.931
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.8140.268
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.8140.415
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.040.787
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of GCK in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.74.1-0.41
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.75.1-1.41
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 111307.7-7.71
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 51208.3-8.31
Summary
SymbolGCK
Nameglucokinase (hexokinase 4)
Aliases MODY2; maturity onset diabetes of the young 2; FGQTL3; HHF3; HKIV; HXKP; LGLK; HK IV; hexokinase D, pancreat ......
Chromosomal Location7p15.3-p15.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GCK. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolGCK
Nameglucokinase (hexokinase 4)
Aliases MODY2; maturity onset diabetes of the young 2; FGQTL3; HHF3; HKIV; HXKP; LGLK; HK IV; hexokinase D, pancreat ......
Chromosomal Location7p15.3-p15.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GCK. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GCK.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolGCK
Nameglucokinase (hexokinase 4)
Aliases MODY2; maturity onset diabetes of the young 2; FGQTL3; HHF3; HKIV; HXKP; LGLK; HK IV; hexokinase D, pancreat ......
Chromosomal Location7p15.3-p15.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GCK. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolGCK
Nameglucokinase (hexokinase 4)
Aliases MODY2; maturity onset diabetes of the young 2; FGQTL3; HHF3; HKIV; HXKP; LGLK; HK IV; hexokinase D, pancreat ......
Chromosomal Location7p15.3-p15.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of GCK expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolGCK
Nameglucokinase (hexokinase 4)
Aliases MODY2; maturity onset diabetes of the young 2; FGQTL3; HHF3; HKIV; HXKP; LGLK; HK IV; hexokinase D, pancreat ......
Chromosomal Location7p15.3-p15.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between GCK and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolGCK
Nameglucokinase (hexokinase 4)
Aliases MODY2; maturity onset diabetes of the young 2; FGQTL3; HHF3; HKIV; HXKP; LGLK; HK IV; hexokinase D, pancreat ......
Chromosomal Location7p15.3-p15.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting GCK collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting GCK.
ID Name Drug Type Targets #Targets
DB02379Beta-D-GlucoseSmall MoleculeAMY1A, AMY2A, AMY2B, GCK, GLT6D1, GNPDA1, HK1, IFNB1, KRTAP5-2, KR ......22
DB073582-amino-N-(4-methyl-1,3-thiazol-2-yl)-5-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]benzamideSmall MoleculeGCK1
DB073593-[(4-fluorophenyl)sulfanyl]-N-(4-methyl-1,3-thiazol-2-yl)-6-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]pyridine-2-carboxamideSmall MoleculeGCK1
DB081182-(methylamino)-N-(4-methyl-1,3-thiazol-2-yl)-5-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]benzamideSmall MoleculeGCK1
DB082102-AMINO-4-FLUORO-5-[(1-METHYL-1H-IMIDAZOL-2-YL)SULFANYL]-N-(1,3-THIAZOL-2-YL)BENZAMIDESmall MoleculeGCK1