Summary | |
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Symbol | GCN1 |
Name | GCN1 eIF2 alpha kinase activator homolog |
Aliases | KIAA0219; GCN1L; GCN1L1; GCN1 (general control of amino-acid synthesis 1, yeast)-like 1; GCN1 general contro ...... |
Chromosomal Location | 12q24.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Note=Associates with ribosomes in undifferentiated neuroblastoma cells and increases after neuronal differentiation. |
Domain | - |
Function |
Acts as a positive activator of the EIF2AK4/GCN2 protein kinase activity in response to amino acid starvation. Forms a complex with EIF2AK4/GCN2 on translating ribosomes; during this process, GCN1 seems to act as a chaperone to facilitate delivery of uncharged tRNAs that enter the A site of ribosomes to the tRNA-binding domain of EIF2AK4/GCN2, and hence stimulating EIF2AK4/GCN2 kinase activity. Participates in the repression of global protein synthesis and in gene-specific mRNA translation activation, such as the transcriptional activator ATF4, by promoting the EIF2AK4/GCN2-mediated phosphorylation of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52', and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion. |
Biological Process |
GO:0006417 regulation of translation GO:0009267 cellular response to starvation GO:0009991 response to extracellular stimulus GO:0010608 posttranscriptional regulation of gene expression GO:0031667 response to nutrient levels GO:0031668 cellular response to extracellular stimulus GO:0031669 cellular response to nutrient levels GO:0033674 positive regulation of kinase activity GO:0034198 cellular response to amino acid starvation GO:0034248 regulation of cellular amide metabolic process GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress GO:0042594 response to starvation GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress GO:0043620 regulation of DNA-templated transcription in response to stress GO:0071496 cellular response to external stimulus GO:1990253 cellular response to leucine starvation |
Molecular Function |
GO:0008135 translation factor activity, RNA binding GO:0019207 kinase regulator activity GO:0019887 protein kinase regulator activity GO:0043021 ribonucleoprotein complex binding GO:0043022 ribosome binding GO:0045296 cadherin binding GO:0050839 cell adhesion molecule binding GO:0098631 protein binding involved in cell adhesion GO:0098632 protein binding involved in cell-cell adhesion GO:0098641 cadherin binding involved in cell-cell adhesion |
Cellular Component |
GO:0005840 ribosome GO:0005844 polysome GO:0005913 cell-cell adherens junction |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | GCN1 |
Name | GCN1 eIF2 alpha kinase activator homolog |
Aliases | KIAA0219; GCN1L; GCN1L1; GCN1 (general control of amino-acid synthesis 1, yeast)-like 1; GCN1 general contro ...... |
Chromosomal Location | 12q24.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between GCN1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | GCN1 |
Name | GCN1 eIF2 alpha kinase activator homolog |
Aliases | KIAA0219; GCN1L; GCN1L1; GCN1 (general control of amino-acid synthesis 1, yeast)-like 1; GCN1 general contro ...... |
Chromosomal Location | 12q24.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of GCN1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | GCN1 |
Name | GCN1 eIF2 alpha kinase activator homolog |
Aliases | KIAA0219; GCN1L; GCN1L1; GCN1 (general control of amino-acid synthesis 1, yeast)-like 1; GCN1 general contro ...... |
Chromosomal Location | 12q24.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of GCN1 in various data sets.
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Points in the above scatter plot represent the mutation difference of GCN1 in various data sets.
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Summary | |
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Symbol | GCN1 |
Name | GCN1 eIF2 alpha kinase activator homolog |
Aliases | KIAA0219; GCN1L; GCN1L1; GCN1 (general control of amino-acid synthesis 1, yeast)-like 1; GCN1 general contro ...... |
Chromosomal Location | 12q24.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GCN1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | GCN1 |
Name | GCN1 eIF2 alpha kinase activator homolog |
Aliases | KIAA0219; GCN1L; GCN1L1; GCN1 (general control of amino-acid synthesis 1, yeast)-like 1; GCN1 general contro ...... |
Chromosomal Location | 12q24.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GCN1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GCN1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | GCN1 |
Name | GCN1 eIF2 alpha kinase activator homolog |
Aliases | KIAA0219; GCN1L; GCN1L1; GCN1 (general control of amino-acid synthesis 1, yeast)-like 1; GCN1 general contro ...... |
Chromosomal Location | 12q24.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GCN1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | GCN1 |
Name | GCN1 eIF2 alpha kinase activator homolog |
Aliases | KIAA0219; GCN1L; GCN1L1; GCN1 (general control of amino-acid synthesis 1, yeast)-like 1; GCN1 general contro ...... |
Chromosomal Location | 12q24.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of GCN1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | GCN1 |
Name | GCN1 eIF2 alpha kinase activator homolog |
Aliases | KIAA0219; GCN1L; GCN1L1; GCN1 (general control of amino-acid synthesis 1, yeast)-like 1; GCN1 general contro ...... |
Chromosomal Location | 12q24.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between GCN1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | GCN1 |
Name | GCN1 eIF2 alpha kinase activator homolog |
Aliases | KIAA0219; GCN1L; GCN1L1; GCN1 (general control of amino-acid synthesis 1, yeast)-like 1; GCN1 general contro ...... |
Chromosomal Location | 12q24.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting GCN1 collected from DrugBank database. |
There is no record. |