Summary | |
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Symbol | GCNT3 |
Name | glucosaminyl (N-acetyl) transferase 3, mucin type |
Aliases | C2GnT-M; C2/4GnT; C2GnT2; C24GNT; C2GNTM; GNTM; C2GnT-mucin type; beta1,6-N-acetylglucosaminyltransferase-M; ...... |
Chromosomal Location | 15q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Golgi apparatus membrane Single-pass type II membrane protein |
Domain |
PF02485 Core-2/I-Branching enzyme |
Function |
Glycosyltransferase that can synthesize all known mucin beta 6 N-acetylglucosaminides. Mediates core 2 and core 4 O-glycan branching, 2 important steps in mucin-type biosynthesis. Has also I-branching enzyme activity by converting linear into branched poly-N-acetyllactosaminoglycans, leading to introduce the blood group I antigen during embryonic development. |
Biological Process |
GO:0001655 urogenital system development GO:0001822 kidney development GO:0002250 adaptive immune response GO:0002251 organ or tissue specific immune response GO:0002377 immunoglobulin production GO:0002381 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002385 mucosal immune response GO:0002426 immunoglobulin production in mucosal tissue GO:0002440 production of molecular mediator of immune response GO:0002443 leukocyte mediated immunity GO:0002449 lymphocyte mediated immunity GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0006486 protein glycosylation GO:0006493 protein O-linked glycosylation GO:0007586 digestion GO:0009100 glycoprotein metabolic process GO:0009101 glycoprotein biosynthetic process GO:0016064 immunoglobulin mediated immune response GO:0016266 O-glycan processing GO:0019724 B cell mediated immunity GO:0022600 digestive system process GO:0043413 macromolecule glycosylation GO:0050892 intestinal absorption GO:0060993 kidney morphogenesis GO:0070085 glycosylation GO:0072001 renal system development |
Molecular Function |
GO:0003829 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity GO:0008194 UDP-glycosyltransferase activity GO:0008375 acetylglucosaminyltransferase activity GO:0016757 transferase activity, transferring glycosyl groups GO:0016758 transferase activity, transferring hexosyl groups GO:0047225 acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity |
Cellular Component | - |
KEGG |
hsa00512 Mucin type O-Glycan biosynthesis hsa01100 Metabolic pathways |
Reactome |
R-HSA-392499: Metabolism of proteins R-HSA-5173105: O-linked glycosylation R-HSA-913709: O-linked glycosylation of mucins R-HSA-597592: Post-translational protein modification |
Summary | |
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Symbol | GCNT3 |
Name | glucosaminyl (N-acetyl) transferase 3, mucin type |
Aliases | C2GnT-M; C2/4GnT; C2GnT2; C24GNT; C2GNTM; GNTM; C2GnT-mucin type; beta1,6-N-acetylglucosaminyltransferase-M; ...... |
Chromosomal Location | 15q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between GCNT3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | GCNT3 |
Name | glucosaminyl (N-acetyl) transferase 3, mucin type |
Aliases | C2GnT-M; C2/4GnT; C2GnT2; C24GNT; C2GNTM; GNTM; C2GnT-mucin type; beta1,6-N-acetylglucosaminyltransferase-M; ...... |
Chromosomal Location | 15q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of GCNT3 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | GCNT3 |
Name | glucosaminyl (N-acetyl) transferase 3, mucin type |
Aliases | C2GnT-M; C2/4GnT; C2GnT2; C24GNT; C2GNTM; GNTM; C2GnT-mucin type; beta1,6-N-acetylglucosaminyltransferase-M; ...... |
Chromosomal Location | 15q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of GCNT3 in various data sets.
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Points in the above scatter plot represent the mutation difference of GCNT3 in various data sets.
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Summary | |
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Symbol | GCNT3 |
Name | glucosaminyl (N-acetyl) transferase 3, mucin type |
Aliases | C2GnT-M; C2/4GnT; C2GnT2; C24GNT; C2GNTM; GNTM; C2GnT-mucin type; beta1,6-N-acetylglucosaminyltransferase-M; ...... |
Chromosomal Location | 15q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GCNT3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | GCNT3 |
Name | glucosaminyl (N-acetyl) transferase 3, mucin type |
Aliases | C2GnT-M; C2/4GnT; C2GnT2; C24GNT; C2GNTM; GNTM; C2GnT-mucin type; beta1,6-N-acetylglucosaminyltransferase-M; ...... |
Chromosomal Location | 15q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GCNT3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GCNT3. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | GCNT3 |
Name | glucosaminyl (N-acetyl) transferase 3, mucin type |
Aliases | C2GnT-M; C2/4GnT; C2GnT2; C24GNT; C2GNTM; GNTM; C2GnT-mucin type; beta1,6-N-acetylglucosaminyltransferase-M; ...... |
Chromosomal Location | 15q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GCNT3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | GCNT3 |
Name | glucosaminyl (N-acetyl) transferase 3, mucin type |
Aliases | C2GnT-M; C2/4GnT; C2GnT2; C24GNT; C2GNTM; GNTM; C2GnT-mucin type; beta1,6-N-acetylglucosaminyltransferase-M; ...... |
Chromosomal Location | 15q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of GCNT3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | GCNT3 |
Name | glucosaminyl (N-acetyl) transferase 3, mucin type |
Aliases | C2GnT-M; C2/4GnT; C2GnT2; C24GNT; C2GNTM; GNTM; C2GnT-mucin type; beta1,6-N-acetylglucosaminyltransferase-M; ...... |
Chromosomal Location | 15q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between GCNT3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | GCNT3 |
Name | glucosaminyl (N-acetyl) transferase 3, mucin type |
Aliases | C2GnT-M; C2/4GnT; C2GnT2; C24GNT; C2GNTM; GNTM; C2GnT-mucin type; beta1,6-N-acetylglucosaminyltransferase-M; ...... |
Chromosomal Location | 15q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting GCNT3 collected from DrugBank database. |
There is no record. |