Summary | |
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Symbol | GDF9 |
Name | growth differentiation factor 9 |
Aliases | GDF-9; Growth/differentiation factor 9 |
Chromosomal Location | 5q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted |
Domain |
PF00019 Transforming growth factor beta like domain |
Function |
Required for ovarian folliculogenesis. Promotes primordial follicle development. Stimulates granulosa cell proliferation. Promotes cell transition from G0/G1 to S and G2/M phases, through an increase of CCND1 and CCNE1 expression, and RB1 phosphorylation. It regulates STAR expression and cAMP-dependent progesterone release in granulosa and thecal cells. Attenuates the suppressive effects of activin A on STAR expression and progesterone production by increasing the expression of inhibin B. It suppresses FST and FSTL3 production in granulosa-lutein cells. |
Biological Process |
GO:0001553 luteinization GO:0001555 oocyte growth GO:0001558 regulation of cell growth GO:0006869 lipid transport GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007179 transforming growth factor beta receptor signaling pathway GO:0007281 germ cell development GO:0007292 female gamete generation GO:0007548 sex differentiation GO:0008406 gonad development GO:0008585 female gonad development GO:0009914 hormone transport GO:0009994 oocyte differentiation GO:0010817 regulation of hormone levels GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010876 lipid localization GO:0016049 cell growth GO:0022412 cellular process involved in reproduction in multicellular organism GO:0022602 ovulation cycle process GO:0023061 signal release GO:0030308 negative regulation of cell growth GO:0030509 BMP signaling pathway GO:0032368 regulation of lipid transport GO:0035929 steroid hormone secretion GO:0042698 ovulation cycle GO:0042701 progesterone secretion GO:0044057 regulation of system process GO:0044060 regulation of endocrine process GO:0045137 development of primary sexual characteristics GO:0045926 negative regulation of growth GO:0046545 development of primary female sexual characteristics GO:0046660 female sex differentiation GO:0046879 hormone secretion GO:0046883 regulation of hormone secretion GO:0048477 oogenesis GO:0048511 rhythmic process GO:0048588 developmental cell growth GO:0048599 oocyte development GO:0048608 reproductive structure development GO:0050886 endocrine process GO:0060389 pathway-restricted SMAD protein phosphorylation GO:0060393 regulation of pathway-restricted SMAD protein phosphorylation GO:0060395 SMAD protein signal transduction GO:0060986 endocrine hormone secretion GO:0061458 reproductive system development GO:0071559 response to transforming growth factor beta GO:0071560 cellular response to transforming growth factor beta stimulus GO:0071772 response to BMP GO:0071773 cellular response to BMP stimulus GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway GO:2000194 regulation of female gonad development GO:2000241 regulation of reproductive process GO:2000831 regulation of steroid hormone secretion GO:2000870 regulation of progesterone secretion |
Molecular Function |
GO:0005125 cytokine activity GO:0005126 cytokine receptor binding GO:0005160 transforming growth factor beta receptor binding GO:0008083 growth factor activity |
Cellular Component | - |
KEGG |
hsa04913 Ovarian steroidogenesis |
Reactome | - |
Summary | |
---|---|
Symbol | GDF9 |
Name | growth differentiation factor 9 |
Aliases | GDF-9; Growth/differentiation factor 9 |
Chromosomal Location | 5q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between GDF9 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | GDF9 |
Name | growth differentiation factor 9 |
Aliases | GDF-9; Growth/differentiation factor 9 |
Chromosomal Location | 5q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of GDF9 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | GDF9 |
Name | growth differentiation factor 9 |
Aliases | GDF-9; Growth/differentiation factor 9 |
Chromosomal Location | 5q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of GDF9 in various data sets.
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Points in the above scatter plot represent the mutation difference of GDF9 in various data sets.
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Summary | |
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Symbol | GDF9 |
Name | growth differentiation factor 9 |
Aliases | GDF-9; Growth/differentiation factor 9 |
Chromosomal Location | 5q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GDF9. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | GDF9 |
Name | growth differentiation factor 9 |
Aliases | GDF-9; Growth/differentiation factor 9 |
Chromosomal Location | 5q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GDF9. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GDF9. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | GDF9 |
Name | growth differentiation factor 9 |
Aliases | GDF-9; Growth/differentiation factor 9 |
Chromosomal Location | 5q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GDF9. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | GDF9 |
Name | growth differentiation factor 9 |
Aliases | GDF-9; Growth/differentiation factor 9 |
Chromosomal Location | 5q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of GDF9 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | GDF9 |
Name | growth differentiation factor 9 |
Aliases | GDF-9; Growth/differentiation factor 9 |
Chromosomal Location | 5q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between GDF9 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |