Summary | |
---|---|
Symbol | GEM |
Name | GTP binding protein overexpressed in skeletal muscle |
Aliases | kinase-inducible Ras-like protein; GTP-binding protein overexpressed in skeletal muscle; GTP-binding mitogen ...... |
Chromosomal Location | 8q13-q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane; Peripheral membrane protein; Cytoplasmic side. |
Domain |
PF00071 Ras family |
Function |
Could be a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity. |
Biological Process |
GO:0007059 chromosome segregation GO:0007067 mitotic nuclear division GO:0050000 chromosome localization GO:0051303 establishment of chromosome localization GO:0051310 metaphase plate congression GO:0051640 organelle localization GO:0051656 establishment of organelle localization GO:0098813 nuclear chromosome segregation |
Molecular Function |
GO:0000287 magnesium ion binding GO:0003924 GTPase activity GO:0005516 calmodulin binding GO:0005525 GTP binding GO:0019001 guanyl nucleotide binding GO:0019003 GDP binding GO:0032561 guanyl ribonucleotide binding |
Cellular Component |
GO:0005819 spindle GO:0009898 cytoplasmic side of plasma membrane GO:0030496 midbody GO:0051233 spindle midzone GO:0072686 mitotic spindle GO:0098552 side of membrane GO:0098562 cytoplasmic side of membrane |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | GEM |
Name | GTP binding protein overexpressed in skeletal muscle |
Aliases | kinase-inducible Ras-like protein; GTP-binding protein overexpressed in skeletal muscle; GTP-binding mitogen ...... |
Chromosomal Location | 8q13-q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between GEM and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | GEM |
Name | GTP binding protein overexpressed in skeletal muscle |
Aliases | kinase-inducible Ras-like protein; GTP-binding protein overexpressed in skeletal muscle; GTP-binding mitogen ...... |
Chromosomal Location | 8q13-q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of GEM in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | GEM |
Name | GTP binding protein overexpressed in skeletal muscle |
Aliases | kinase-inducible Ras-like protein; GTP-binding protein overexpressed in skeletal muscle; GTP-binding mitogen ...... |
Chromosomal Location | 8q13-q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of GEM in various data sets.
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Points in the above scatter plot represent the mutation difference of GEM in various data sets.
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Summary | |
---|---|
Symbol | GEM |
Name | GTP binding protein overexpressed in skeletal muscle |
Aliases | kinase-inducible Ras-like protein; GTP-binding protein overexpressed in skeletal muscle; GTP-binding mitogen ...... |
Chromosomal Location | 8q13-q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GEM. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | GEM |
Name | GTP binding protein overexpressed in skeletal muscle |
Aliases | kinase-inducible Ras-like protein; GTP-binding protein overexpressed in skeletal muscle; GTP-binding mitogen ...... |
Chromosomal Location | 8q13-q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GEM. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GEM. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | GEM |
Name | GTP binding protein overexpressed in skeletal muscle |
Aliases | kinase-inducible Ras-like protein; GTP-binding protein overexpressed in skeletal muscle; GTP-binding mitogen ...... |
Chromosomal Location | 8q13-q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GEM. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | GEM |
Name | GTP binding protein overexpressed in skeletal muscle |
Aliases | kinase-inducible Ras-like protein; GTP-binding protein overexpressed in skeletal muscle; GTP-binding mitogen ...... |
Chromosomal Location | 8q13-q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of GEM expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | GEM |
Name | GTP binding protein overexpressed in skeletal muscle |
Aliases | kinase-inducible Ras-like protein; GTP-binding protein overexpressed in skeletal muscle; GTP-binding mitogen ...... |
Chromosomal Location | 8q13-q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between GEM and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | GEM |
Name | GTP binding protein overexpressed in skeletal muscle |
Aliases | kinase-inducible Ras-like protein; GTP-binding protein overexpressed in skeletal muscle; GTP-binding mitogen ...... |
Chromosomal Location | 8q13-q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting GEM collected from DrugBank database. |
There is no record. |