Browse GEM

Summary
SymbolGEM
NameGTP binding protein overexpressed in skeletal muscle
Aliases kinase-inducible Ras-like protein; GTP-binding protein overexpressed in skeletal muscle; GTP-binding mitogen ......
Chromosomal Location8q13-q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Domain PF00071 Ras family
Function

Could be a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity.

> Gene Ontology
 
Biological Process GO:0007059 chromosome segregation
GO:0007067 mitotic nuclear division
GO:0050000 chromosome localization
GO:0051303 establishment of chromosome localization
GO:0051310 metaphase plate congression
GO:0051640 organelle localization
GO:0051656 establishment of organelle localization
GO:0098813 nuclear chromosome segregation
Molecular Function GO:0000287 magnesium ion binding
GO:0003924 GTPase activity
GO:0005516 calmodulin binding
GO:0005525 GTP binding
GO:0019001 guanyl nucleotide binding
GO:0019003 GDP binding
GO:0032561 guanyl ribonucleotide binding
Cellular Component GO:0005819 spindle
GO:0009898 cytoplasmic side of plasma membrane
GO:0030496 midbody
GO:0051233 spindle midzone
GO:0072686 mitotic spindle
GO:0098552 side of membrane
GO:0098562 cytoplasmic side of membrane
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolGEM
NameGTP binding protein overexpressed in skeletal muscle
Aliases kinase-inducible Ras-like protein; GTP-binding protein overexpressed in skeletal muscle; GTP-binding mitogen ......
Chromosomal Location8q13-q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between GEM and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolGEM
NameGTP binding protein overexpressed in skeletal muscle
Aliases kinase-inducible Ras-like protein; GTP-binding protein overexpressed in skeletal muscle; GTP-binding mitogen ......
Chromosomal Location8q13-q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of GEM in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolGEM
NameGTP binding protein overexpressed in skeletal muscle
Aliases kinase-inducible Ras-like protein; GTP-binding protein overexpressed in skeletal muscle; GTP-binding mitogen ......
Chromosomal Location8q13-q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of GEM in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-1.430.0109
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-1.7610.28
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-1.1870.336
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.5260.425
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.60.737
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.4250.859
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0110.98
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.5480.651
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.5240.708
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.440.711
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.6660.299
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.6370.00618
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of GEM in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.72.711
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.73.40.31
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211714.3014.30.238
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131115.4015.40.482
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.1011.10.36
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59200200.357
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolGEM
NameGTP binding protein overexpressed in skeletal muscle
Aliases kinase-inducible Ras-like protein; GTP-binding protein overexpressed in skeletal muscle; GTP-binding mitogen ......
Chromosomal Location8q13-q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GEM. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolGEM
NameGTP binding protein overexpressed in skeletal muscle
Aliases kinase-inducible Ras-like protein; GTP-binding protein overexpressed in skeletal muscle; GTP-binding mitogen ......
Chromosomal Location8q13-q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GEM. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GEM.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolGEM
NameGTP binding protein overexpressed in skeletal muscle
Aliases kinase-inducible Ras-like protein; GTP-binding protein overexpressed in skeletal muscle; GTP-binding mitogen ......
Chromosomal Location8q13-q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GEM. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolGEM
NameGTP binding protein overexpressed in skeletal muscle
Aliases kinase-inducible Ras-like protein; GTP-binding protein overexpressed in skeletal muscle; GTP-binding mitogen ......
Chromosomal Location8q13-q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of GEM expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolGEM
NameGTP binding protein overexpressed in skeletal muscle
Aliases kinase-inducible Ras-like protein; GTP-binding protein overexpressed in skeletal muscle; GTP-binding mitogen ......
Chromosomal Location8q13-q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between GEM and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolGEM
NameGTP binding protein overexpressed in skeletal muscle
Aliases kinase-inducible Ras-like protein; GTP-binding protein overexpressed in skeletal muscle; GTP-binding mitogen ......
Chromosomal Location8q13-q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting GEM collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.