Browse GFPT2

Summary
SymbolGFPT2
Nameglutamine-fructose-6-phosphate transaminase 2
Aliases GFAT2; glutamine: fructose-6-phosphate aminotransferase 2; D-fructose-6-phosphate amidotransferase 2; GFAT 2 ......
Chromosomal Location5q
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location -
Domain PF01380 SIS domain
Function

Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins.

> Gene Ontology
 
Biological Process GO:0006002 fructose 6-phosphate metabolic process
GO:0006040 amino sugar metabolic process
GO:0006047 UDP-N-acetylglucosamine metabolic process
GO:0006048 UDP-N-acetylglucosamine biosynthetic process
GO:0006091 generation of precursor metabolites and energy
GO:0006112 energy reserve metabolic process
GO:0006520 cellular amino acid metabolic process
GO:0006541 glutamine metabolic process
GO:0009064 glutamine family amino acid metabolic process
GO:0009225 nucleotide-sugar metabolic process
GO:0009226 nucleotide-sugar biosynthetic process
GO:0015980 energy derivation by oxidation of organic compounds
GO:0046349 amino sugar biosynthetic process
GO:1901605 alpha-amino acid metabolic process
Molecular Function GO:0004360 glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GO:0008483 transaminase activity
GO:0016769 transferase activity, transferring nitrogenous groups
GO:0030246 carbohydrate binding
GO:0070548 L-glutamine aminotransferase activity
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa00250 Alanine, aspartate and glutamate metabolism
hsa00520 Amino sugar and nucleotide sugar metabolism
hsa01100 Metabolic pathways
Reactome R-HSA-446203: Asparagine N-linked glycosylation
R-HSA-446193: Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
R-HSA-392499: Metabolism of proteins
R-HSA-597592: Post-translational protein modification
R-HSA-446210: Synthesis of UDP-N-acetyl-glucosamine
R-HSA-446219: Synthesis of substrates in N-glycan biosythesis
Summary
SymbolGFPT2
Nameglutamine-fructose-6-phosphate transaminase 2
Aliases GFAT2; glutamine: fructose-6-phosphate aminotransferase 2; D-fructose-6-phosphate amidotransferase 2; GFAT 2 ......
Chromosomal Location5q
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between GFPT2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolGFPT2
Nameglutamine-fructose-6-phosphate transaminase 2
Aliases GFAT2; glutamine: fructose-6-phosphate aminotransferase 2; D-fructose-6-phosphate amidotransferase 2; GFAT 2 ......
Chromosomal Location5q
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of GFPT2 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolGFPT2
Nameglutamine-fructose-6-phosphate transaminase 2
Aliases GFAT2; glutamine: fructose-6-phosphate aminotransferase 2; D-fructose-6-phosphate amidotransferase 2; GFAT 2 ......
Chromosomal Location5q
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of GFPT2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-1.330.00659
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-1.0950.49
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-1.4840.123
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.7710.223
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-1.2940.462
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.1060.963
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.3040.576
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.4650.712
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.1140.935
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 482.0160.0624
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 282.930.0604
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.5640.0686
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of GFPT2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277311.1011.10.0181
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275911.1011.10.0286
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47014.3-14.31
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolGFPT2
Nameglutamine-fructose-6-phosphate transaminase 2
Aliases GFAT2; glutamine: fructose-6-phosphate aminotransferase 2; D-fructose-6-phosphate amidotransferase 2; GFAT 2 ......
Chromosomal Location5q
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GFPT2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolGFPT2
Nameglutamine-fructose-6-phosphate transaminase 2
Aliases GFAT2; glutamine: fructose-6-phosphate aminotransferase 2; D-fructose-6-phosphate amidotransferase 2; GFAT 2 ......
Chromosomal Location5q
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GFPT2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GFPT2.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolGFPT2
Nameglutamine-fructose-6-phosphate transaminase 2
Aliases GFAT2; glutamine: fructose-6-phosphate aminotransferase 2; D-fructose-6-phosphate amidotransferase 2; GFAT 2 ......
Chromosomal Location5q
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GFPT2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolGFPT2
Nameglutamine-fructose-6-phosphate transaminase 2
Aliases GFAT2; glutamine: fructose-6-phosphate aminotransferase 2; D-fructose-6-phosphate amidotransferase 2; GFAT 2 ......
Chromosomal Location5q
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of GFPT2 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolGFPT2
Nameglutamine-fructose-6-phosphate transaminase 2
Aliases GFAT2; glutamine: fructose-6-phosphate aminotransferase 2; D-fructose-6-phosphate amidotransferase 2; GFAT 2 ......
Chromosomal Location5q
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between GFPT2 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolGFPT2
Nameglutamine-fructose-6-phosphate transaminase 2
Aliases GFAT2; glutamine: fructose-6-phosphate aminotransferase 2; D-fructose-6-phosphate amidotransferase 2; GFAT 2 ......
Chromosomal Location5q
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting GFPT2 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.