Summary | |
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Symbol | GFRA2 |
Name | GDNF family receptor alpha 2 |
Aliases | RETL2; GDNFRB; NTNRA; TRNR2; NRTNR-ALPHA; GDNF receptor beta; GDNFR-alpha-2; GDNFR-beta; GFR-alpha 2; NTNR-a ...... |
Chromosomal Location | 8p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Lipid-anchor, GPI-anchor |
Domain |
PF02351 GDNF/GAS1 domain |
Function |
Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor.; FUNCTION: Isoform 2: participates in NRTN-induced 'Ser-727' phosphorylation of STAT3. |
Biological Process |
GO:0001933 negative regulation of protein phosphorylation GO:0007259 JAK-STAT cascade GO:0018105 peptidyl-serine phosphorylation GO:0018209 peptidyl-serine modification GO:0031952 regulation of protein autophosphorylation GO:0031953 negative regulation of protein autophosphorylation GO:0033135 regulation of peptidyl-serine phosphorylation GO:0033136 serine phosphorylation of STAT3 protein GO:0033138 positive regulation of peptidyl-serine phosphorylation GO:0033139 regulation of peptidyl-serine phosphorylation of STAT protein GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway GO:0042326 negative regulation of phosphorylation GO:0042501 serine phosphorylation of STAT protein GO:0046425 regulation of JAK-STAT cascade GO:0046777 protein autophosphorylation GO:0097696 STAT cascade GO:1903261 regulation of serine phosphorylation of STAT3 protein GO:1903263 positive regulation of serine phosphorylation of STAT3 protein GO:1904892 regulation of STAT cascade |
Molecular Function |
GO:0004896 cytokine receptor activity GO:0005085 guanyl-nucleotide exchange factor activity GO:0005088 Ras guanyl-nucleotide exchange factor activity GO:0016167 glial cell-derived neurotrophic factor receptor activity |
Cellular Component |
GO:0019898 extrinsic component of membrane GO:0031225 anchored component of membrane |
KEGG | - |
Reactome |
R-HSA-170984: ARMS-mediated activation R-HSA-422475: Axon guidance R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-2172127: DAP12 interactions R-HSA-2424491: DAP12 signaling R-HSA-1266738: Developmental Biology R-HSA-186763: Downstream signal transduction R-HSA-2871796: FCERI mediated MAPK activation R-HSA-2454202: Fc epsilon receptor (FCERI) signaling R-HSA-170968: Frs2-mediated activation R-HSA-179812: GRB2 events in EGFR signaling R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-2428924: IGF1R signaling cascade R-HSA-112399: IRS-mediated signalling R-HSA-2428928: IRS-related events triggered by IGF1R R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-74751: Insulin receptor signalling cascade R-HSA-912526: Interleukin receptor SHC signaling R-HSA-451927: Interleukin-2 signaling R-HSA-512988: Interleukin-3, 5 and GM-CSF signaling R-HSA-5683057: MAPK family signaling cascades R-HSA-5684996: MAPK1/MAPK3 signaling R-HSA-375165: NCAM signaling for neurite out-growth R-HSA-419037: NCAM1 interactions R-HSA-187037: NGF signalling via TRKA from the plasma membrane R-HSA-169893: Prolonged ERK activation events R-HSA-5673001: RAF/MAP kinase cascade R-HSA-8853659: RET signaling R-HSA-180336: SHC1 events in EGFR signaling R-HSA-112412: SOS-mediated signalling R-HSA-162582: Signal Transduction R-HSA-177929: Signaling by EGFR R-HSA-372790: Signaling by GPCR R-HSA-74752: Signaling by Insulin receptor R-HSA-449147: Signaling by Interleukins R-HSA-2586552: Signaling by Leptin R-HSA-186797: Signaling by PDGF R-HSA-1433557: Signaling by SCF-KIT R-HSA-2404192: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-194138: Signaling by VEGF R-HSA-166520: Signalling by NGF R-HSA-187687: Signalling to ERKs R-HSA-167044: Signalling to RAS R-HSA-187706: Signalling to p38 via RIT and RIN R-HSA-4420097: VEGFA-VEGFR2 Pathway R-HSA-5218921: VEGFR2 mediated cell proliferation |
Summary | |
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Symbol | GFRA2 |
Name | GDNF family receptor alpha 2 |
Aliases | RETL2; GDNFRB; NTNRA; TRNR2; NRTNR-ALPHA; GDNF receptor beta; GDNFR-alpha-2; GDNFR-beta; GFR-alpha 2; NTNR-a ...... |
Chromosomal Location | 8p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between GFRA2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | GFRA2 |
Name | GDNF family receptor alpha 2 |
Aliases | RETL2; GDNFRB; NTNRA; TRNR2; NRTNR-ALPHA; GDNF receptor beta; GDNFR-alpha-2; GDNFR-beta; GFR-alpha 2; NTNR-a ...... |
Chromosomal Location | 8p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of GFRA2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | GFRA2 |
Name | GDNF family receptor alpha 2 |
Aliases | RETL2; GDNFRB; NTNRA; TRNR2; NRTNR-ALPHA; GDNF receptor beta; GDNFR-alpha-2; GDNFR-beta; GFR-alpha 2; NTNR-a ...... |
Chromosomal Location | 8p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of GFRA2 in various data sets.
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Points in the above scatter plot represent the mutation difference of GFRA2 in various data sets.
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Summary | |
---|---|
Symbol | GFRA2 |
Name | GDNF family receptor alpha 2 |
Aliases | RETL2; GDNFRB; NTNRA; TRNR2; NRTNR-ALPHA; GDNF receptor beta; GDNFR-alpha-2; GDNFR-beta; GFR-alpha 2; NTNR-a ...... |
Chromosomal Location | 8p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GFRA2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | GFRA2 |
Name | GDNF family receptor alpha 2 |
Aliases | RETL2; GDNFRB; NTNRA; TRNR2; NRTNR-ALPHA; GDNF receptor beta; GDNFR-alpha-2; GDNFR-beta; GFR-alpha 2; NTNR-a ...... |
Chromosomal Location | 8p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GFRA2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GFRA2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | GFRA2 |
Name | GDNF family receptor alpha 2 |
Aliases | RETL2; GDNFRB; NTNRA; TRNR2; NRTNR-ALPHA; GDNF receptor beta; GDNFR-alpha-2; GDNFR-beta; GFR-alpha 2; NTNR-a ...... |
Chromosomal Location | 8p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GFRA2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | GFRA2 |
Name | GDNF family receptor alpha 2 |
Aliases | RETL2; GDNFRB; NTNRA; TRNR2; NRTNR-ALPHA; GDNF receptor beta; GDNFR-alpha-2; GDNFR-beta; GFR-alpha 2; NTNR-a ...... |
Chromosomal Location | 8p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of GFRA2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | GFRA2 |
Name | GDNF family receptor alpha 2 |
Aliases | RETL2; GDNFRB; NTNRA; TRNR2; NRTNR-ALPHA; GDNF receptor beta; GDNFR-alpha-2; GDNFR-beta; GFR-alpha 2; NTNR-a ...... |
Chromosomal Location | 8p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between GFRA2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | GFRA2 |
Name | GDNF family receptor alpha 2 |
Aliases | RETL2; GDNFRB; NTNRA; TRNR2; NRTNR-ALPHA; GDNF receptor beta; GDNFR-alpha-2; GDNFR-beta; GFR-alpha 2; NTNR-a ...... |
Chromosomal Location | 8p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting GFRA2 collected from DrugBank database. |
There is no record. |