Summary | |
---|---|
Symbol | GFY |
Name | golgi-associated, olfactory signaling regulator |
Aliases | Goofy; Golgi protein in olfactory neurons; golgi-associated olfactory signaling regulator; protein Goofy |
Chromosomal Location | 19q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Golgi apparatus membrane Single-pass type I membrane protein |
Domain | - |
Function |
Required for proper function of the olfactory system. May be involved in establishing the acuity of olfactory sensory signaling (By similarity). |
Biological Process |
GO:0007608 sensory perception of smell GO:0060271 cilium morphogenesis GO:0061512 protein localization to cilium GO:0097499 protein localization to nonmotile primary cilium |
Molecular Function | - |
Cellular Component |
GO:0030173 integral component of Golgi membrane GO:0031228 intrinsic component of Golgi membrane GO:0031300 intrinsic component of organelle membrane GO:0031301 integral component of organelle membrane |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | GFY |
Name | golgi-associated, olfactory signaling regulator |
Aliases | Goofy; Golgi protein in olfactory neurons; golgi-associated olfactory signaling regulator; protein Goofy |
Chromosomal Location | 19q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between GFY and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | GFY |
Name | golgi-associated, olfactory signaling regulator |
Aliases | Goofy; Golgi protein in olfactory neurons; golgi-associated olfactory signaling regulator; protein Goofy |
Chromosomal Location | 19q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of GFY in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | GFY |
Name | golgi-associated, olfactory signaling regulator |
Aliases | Goofy; Golgi protein in olfactory neurons; golgi-associated olfactory signaling regulator; protein Goofy |
Chromosomal Location | 19q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of GFY in various data sets.
|
Points in the above scatter plot represent the mutation difference of GFY in various data sets.
|
Summary | |
---|---|
Symbol | GFY |
Name | golgi-associated, olfactory signaling regulator |
Aliases | Goofy; Golgi protein in olfactory neurons; golgi-associated olfactory signaling regulator; protein Goofy |
Chromosomal Location | 19q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GFY. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | GFY |
Name | golgi-associated, olfactory signaling regulator |
Aliases | Goofy; Golgi protein in olfactory neurons; golgi-associated olfactory signaling regulator; protein Goofy |
Chromosomal Location | 19q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GFY. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GFY. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | GFY |
Name | golgi-associated, olfactory signaling regulator |
Aliases | Goofy; Golgi protein in olfactory neurons; golgi-associated olfactory signaling regulator; protein Goofy |
Chromosomal Location | 19q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GFY. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | GFY |
Name | golgi-associated, olfactory signaling regulator |
Aliases | Goofy; Golgi protein in olfactory neurons; golgi-associated olfactory signaling regulator; protein Goofy |
Chromosomal Location | 19q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of GFY expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | GFY |
Name | golgi-associated, olfactory signaling regulator |
Aliases | Goofy; Golgi protein in olfactory neurons; golgi-associated olfactory signaling regulator; protein Goofy |
Chromosomal Location | 19q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between GFY and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | GFY |
Name | golgi-associated, olfactory signaling regulator |
Aliases | Goofy; Golgi protein in olfactory neurons; golgi-associated olfactory signaling regulator; protein Goofy |
Chromosomal Location | 19q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting GFY collected from DrugBank database. |
There is no record. |