Summary | |
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Symbol | GGH |
Name | gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) |
Aliases | gamma-Glu-X carboxypeptidase; Conjugase; Gamma-glutamyl hydrolase |
Chromosomal Location | 8q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted, extracellular space Lysosome Melanosome Note=While its intracellular location is primarily the lysosome, most of the enzyme activity is secreted. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. |
Domain |
PF07722 Peptidase C26 |
Function |
Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates. |
Biological Process |
GO:0006520 cellular amino acid metabolic process GO:0006541 glutamine metabolic process GO:0006575 cellular modified amino acid metabolic process GO:0006732 coenzyme metabolic process GO:0006760 folic acid-containing compound metabolic process GO:0009064 glutamine family amino acid metabolic process GO:0010035 response to inorganic substance GO:0010038 response to metal ion GO:0010043 response to zinc ion GO:0032868 response to insulin GO:0042493 response to drug GO:0042558 pteridine-containing compound metabolic process GO:0043434 response to peptide hormone GO:0045471 response to ethanol GO:0046900 tetrahydrofolylpolyglutamate metabolic process GO:0051186 cofactor metabolic process GO:0097305 response to alcohol GO:1901605 alpha-amino acid metabolic process GO:1901652 response to peptide GO:1990267 response to transition metal nanoparticle |
Molecular Function |
GO:0008238 exopeptidase activity GO:0008242 omega peptidase activity GO:0034722 gamma-glutamyl-peptidase activity |
Cellular Component |
GO:0042470 melanosome GO:0048770 pigment granule |
KEGG |
hsa00790 Folate biosynthesis |
Reactome |
R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-6798695: Neutrophil degranulation |
Summary | |
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Symbol | GGH |
Name | gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) |
Aliases | gamma-Glu-X carboxypeptidase; Conjugase; Gamma-glutamyl hydrolase |
Chromosomal Location | 8q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between GGH and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | GGH |
Name | gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) |
Aliases | gamma-Glu-X carboxypeptidase; Conjugase; Gamma-glutamyl hydrolase |
Chromosomal Location | 8q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of GGH in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | GGH |
Name | gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) |
Aliases | gamma-Glu-X carboxypeptidase; Conjugase; Gamma-glutamyl hydrolase |
Chromosomal Location | 8q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of GGH in various data sets.
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Points in the above scatter plot represent the mutation difference of GGH in various data sets.
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Summary | |
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Symbol | GGH |
Name | gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) |
Aliases | gamma-Glu-X carboxypeptidase; Conjugase; Gamma-glutamyl hydrolase |
Chromosomal Location | 8q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GGH. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | GGH |
Name | gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) |
Aliases | gamma-Glu-X carboxypeptidase; Conjugase; Gamma-glutamyl hydrolase |
Chromosomal Location | 8q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GGH. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GGH. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | GGH |
Name | gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) |
Aliases | gamma-Glu-X carboxypeptidase; Conjugase; Gamma-glutamyl hydrolase |
Chromosomal Location | 8q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GGH. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | GGH |
Name | gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) |
Aliases | gamma-Glu-X carboxypeptidase; Conjugase; Gamma-glutamyl hydrolase |
Chromosomal Location | 8q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of GGH expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | GGH |
Name | gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) |
Aliases | gamma-Glu-X carboxypeptidase; Conjugase; Gamma-glutamyl hydrolase |
Chromosomal Location | 8q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between GGH and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | GGH |
Name | gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) |
Aliases | gamma-Glu-X carboxypeptidase; Conjugase; Gamma-glutamyl hydrolase |
Chromosomal Location | 8q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting GGH collected from DrugBank database. |
There is no record. |