Browse GGH

Summary
SymbolGGH
Namegamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
Aliases gamma-Glu-X carboxypeptidase; Conjugase; Gamma-glutamyl hydrolase
Chromosomal Location8q12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Secreted, extracellular space Lysosome Melanosome Note=While its intracellular location is primarily the lysosome, most of the enzyme activity is secreted. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Domain PF07722 Peptidase C26
Function

Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates.

> Gene Ontology
 
Biological Process GO:0006520 cellular amino acid metabolic process
GO:0006541 glutamine metabolic process
GO:0006575 cellular modified amino acid metabolic process
GO:0006732 coenzyme metabolic process
GO:0006760 folic acid-containing compound metabolic process
GO:0009064 glutamine family amino acid metabolic process
GO:0010035 response to inorganic substance
GO:0010038 response to metal ion
GO:0010043 response to zinc ion
GO:0032868 response to insulin
GO:0042493 response to drug
GO:0042558 pteridine-containing compound metabolic process
GO:0043434 response to peptide hormone
GO:0045471 response to ethanol
GO:0046900 tetrahydrofolylpolyglutamate metabolic process
GO:0051186 cofactor metabolic process
GO:0097305 response to alcohol
GO:1901605 alpha-amino acid metabolic process
GO:1901652 response to peptide
GO:1990267 response to transition metal nanoparticle
Molecular Function GO:0008238 exopeptidase activity
GO:0008242 omega peptidase activity
GO:0034722 gamma-glutamyl-peptidase activity
Cellular Component GO:0042470 melanosome
GO:0048770 pigment granule
> KEGG and Reactome Pathway
 
KEGG hsa00790 Folate biosynthesis
Reactome R-HSA-168256: Immune System
R-HSA-168249: Innate Immune System
R-HSA-6798695: Neutrophil degranulation
Summary
SymbolGGH
Namegamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
Aliases gamma-Glu-X carboxypeptidase; Conjugase; Gamma-glutamyl hydrolase
Chromosomal Location8q12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between GGH and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolGGH
Namegamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
Aliases gamma-Glu-X carboxypeptidase; Conjugase; Gamma-glutamyl hydrolase
Chromosomal Location8q12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of GGH in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolGGH
Namegamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
Aliases gamma-Glu-X carboxypeptidase; Conjugase; Gamma-glutamyl hydrolase
Chromosomal Location8q12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of GGH in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.6340.0335
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-1.1250.663
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.2720.882
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.3560.505
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.3830.732
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.320.805
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.2110.688
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.6990.679
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.3180.866
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.0360.981
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.470.834
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.5670.000404
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of GGH in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.703.70.27
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.703.70.314
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47014.3-14.31
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.305.30.507
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22139.109.10.519
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolGGH
Namegamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
Aliases gamma-Glu-X carboxypeptidase; Conjugase; Gamma-glutamyl hydrolase
Chromosomal Location8q12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GGH. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolGGH
Namegamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
Aliases gamma-Glu-X carboxypeptidase; Conjugase; Gamma-glutamyl hydrolase
Chromosomal Location8q12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GGH. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GGH.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolGGH
Namegamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
Aliases gamma-Glu-X carboxypeptidase; Conjugase; Gamma-glutamyl hydrolase
Chromosomal Location8q12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GGH. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolGGH
Namegamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
Aliases gamma-Glu-X carboxypeptidase; Conjugase; Gamma-glutamyl hydrolase
Chromosomal Location8q12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of GGH expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolGGH
Namegamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
Aliases gamma-Glu-X carboxypeptidase; Conjugase; Gamma-glutamyl hydrolase
Chromosomal Location8q12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between GGH and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolGGH
Namegamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
Aliases gamma-Glu-X carboxypeptidase; Conjugase; Gamma-glutamyl hydrolase
Chromosomal Location8q12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting GGH collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.