Summary | |
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Symbol | GGT5 |
Name | gamma-glutamyltransferase 5 |
Aliases | GGT-REL; GGTLA1; gamma-glutamyltransferase-like activity 1; GGL; GGT 5; gamma-glutamyl cleaving enzyme; gamm ...... |
Chromosomal Location | 22q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane Single-pass type II membrane protein |
Domain | - |
Function |
Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4). |
Biological Process |
GO:0006520 cellular amino acid metabolic process GO:0006575 cellular modified amino acid metabolic process GO:0006631 fatty acid metabolic process GO:0006633 fatty acid biosynthetic process GO:0006636 unsaturated fatty acid biosynthetic process GO:0006690 icosanoid metabolic process GO:0006691 leukotriene metabolic process GO:0006749 glutathione metabolic process GO:0006750 glutathione biosynthetic process GO:0006790 sulfur compound metabolic process GO:0016053 organic acid biosynthetic process GO:0019184 nonribosomal peptide biosynthetic process GO:0019370 leukotriene biosynthetic process GO:0033559 unsaturated fatty acid metabolic process GO:0042398 cellular modified amino acid biosynthetic process GO:0044272 sulfur compound biosynthetic process GO:0044283 small molecule biosynthetic process GO:0046394 carboxylic acid biosynthetic process GO:0046456 icosanoid biosynthetic process GO:0072330 monocarboxylic acid biosynthetic process |
Molecular Function |
GO:0003840 gamma-glutamyltransferase activity GO:0008238 exopeptidase activity GO:0008242 omega peptidase activity GO:0016746 transferase activity, transferring acyl groups GO:0016755 transferase activity, transferring amino-acyl groups GO:0036374 glutathione hydrolase activity |
Cellular Component |
GO:0009897 external side of plasma membrane GO:0031225 anchored component of membrane GO:0031233 intrinsic component of external side of plasma membrane GO:0031362 anchored component of external side of plasma membrane GO:0046658 anchored component of plasma membrane GO:0098552 side of membrane |
KEGG |
hsa00430 Taurine and hypotaurine metabolism hsa00480 Glutathione metabolism hsa00590 Arachidonic acid metabolism hsa01100 Metabolic pathways |
Reactome |
R-HSA-5423646: Aflatoxin activation and detoxification R-HSA-2142753: Arachidonic acid metabolism R-HSA-211859: Biological oxidations R-HSA-156590: Glutathione conjugation R-HSA-174403: Glutathione synthesis and recycling R-HSA-1430728: Metabolism R-HSA-556833: Metabolism of lipids and lipoproteins R-HSA-156580: Phase II conjugation R-HSA-2142691: Synthesis of Leukotrienes (LT) and Eoxins (EX) |
Summary | |
---|---|
Symbol | GGT5 |
Name | gamma-glutamyltransferase 5 |
Aliases | GGT-REL; GGTLA1; gamma-glutamyltransferase-like activity 1; GGL; GGT 5; gamma-glutamyl cleaving enzyme; gamm ...... |
Chromosomal Location | 22q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between GGT5 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | GGT5 |
Name | gamma-glutamyltransferase 5 |
Aliases | GGT-REL; GGTLA1; gamma-glutamyltransferase-like activity 1; GGL; GGT 5; gamma-glutamyl cleaving enzyme; gamm ...... |
Chromosomal Location | 22q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of GGT5 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | GGT5 |
Name | gamma-glutamyltransferase 5 |
Aliases | GGT-REL; GGTLA1; gamma-glutamyltransferase-like activity 1; GGL; GGT 5; gamma-glutamyl cleaving enzyme; gamm ...... |
Chromosomal Location | 22q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of GGT5 in various data sets.
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Points in the above scatter plot represent the mutation difference of GGT5 in various data sets.
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Summary | |
---|---|
Symbol | GGT5 |
Name | gamma-glutamyltransferase 5 |
Aliases | GGT-REL; GGTLA1; gamma-glutamyltransferase-like activity 1; GGL; GGT 5; gamma-glutamyl cleaving enzyme; gamm ...... |
Chromosomal Location | 22q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GGT5. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | GGT5 |
Name | gamma-glutamyltransferase 5 |
Aliases | GGT-REL; GGTLA1; gamma-glutamyltransferase-like activity 1; GGL; GGT 5; gamma-glutamyl cleaving enzyme; gamm ...... |
Chromosomal Location | 22q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GGT5. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GGT5. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | GGT5 |
Name | gamma-glutamyltransferase 5 |
Aliases | GGT-REL; GGTLA1; gamma-glutamyltransferase-like activity 1; GGL; GGT 5; gamma-glutamyl cleaving enzyme; gamm ...... |
Chromosomal Location | 22q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GGT5. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | GGT5 |
Name | gamma-glutamyltransferase 5 |
Aliases | GGT-REL; GGTLA1; gamma-glutamyltransferase-like activity 1; GGL; GGT 5; gamma-glutamyl cleaving enzyme; gamm ...... |
Chromosomal Location | 22q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of GGT5 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | GGT5 |
Name | gamma-glutamyltransferase 5 |
Aliases | GGT-REL; GGTLA1; gamma-glutamyltransferase-like activity 1; GGL; GGT 5; gamma-glutamyl cleaving enzyme; gamm ...... |
Chromosomal Location | 22q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between GGT5 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | GGT5 |
Name | gamma-glutamyltransferase 5 |
Aliases | GGT-REL; GGTLA1; gamma-glutamyltransferase-like activity 1; GGL; GGT 5; gamma-glutamyl cleaving enzyme; gamm ...... |
Chromosomal Location | 22q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting GGT5 collected from DrugBank database. |
There is no record. |