Browse GHRHR

Summary
SymbolGHRHR
Namegrowth hormone releasing hormone receptor
Aliases GHRFR; GRFR; GHRH receptor; GRF receptor; Growth hormone-releasing factor receptor; Growth hormone-releasing ......
Chromosomal Location7p14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane; Multi-pass membrane protein.
Domain PF00002 7 transmembrane receptor (Secretin family)
PF02793 Hormone receptor domain
Function

Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion.

> Gene Ontology
 
Biological Process GO:0001678 cellular glucose homeostasis
GO:0002790 peptide secretion
GO:0002791 regulation of peptide secretion
GO:0002793 positive regulation of peptide secretion
GO:0006140 regulation of nucleotide metabolic process
GO:0006164 purine nucleotide biosynthetic process
GO:0006171 cAMP biosynthetic process
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007190 activation of adenylate cyclase activity
GO:0007568 aging
GO:0007589 body fluid secretion
GO:0007595 lactation
GO:0007622 rhythmic behavior
GO:0007623 circadian rhythm
GO:0008340 determination of adult lifespan
GO:0009150 purine ribonucleotide metabolic process
GO:0009152 purine ribonucleotide biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0009187 cyclic nucleotide metabolic process
GO:0009190 cyclic nucleotide biosynthetic process
GO:0009260 ribonucleotide biosynthetic process
GO:0009743 response to carbohydrate
GO:0009746 response to hexose
GO:0009749 response to glucose
GO:0009755 hormone-mediated signaling pathway
GO:0009914 hormone transport
GO:0010259 multicellular organism aging
GO:0010817 regulation of hormone levels
GO:0015833 peptide transport
GO:0019932 second-messenger-mediated signaling
GO:0019933 cAMP-mediated signaling
GO:0019935 cyclic-nucleotide-mediated signaling
GO:0021536 diencephalon development
GO:0021700 developmental maturation
GO:0021983 pituitary gland development
GO:0021984 adenohypophysis development
GO:0022410 circadian sleep/wake cycle process
GO:0023061 signal release
GO:0030072 peptide hormone secretion
GO:0030104 water homeostasis
GO:0030252 growth hormone secretion
GO:0030431 sleep
GO:0030518 intracellular steroid hormone receptor signaling pathway
GO:0030522 intracellular receptor signaling pathway
GO:0030799 regulation of cyclic nucleotide metabolic process
GO:0030801 positive regulation of cyclic nucleotide metabolic process
GO:0030802 regulation of cyclic nucleotide biosynthetic process
GO:0030804 positive regulation of cyclic nucleotide biosynthetic process
GO:0030808 regulation of nucleotide biosynthetic process
GO:0030810 positive regulation of nucleotide biosynthetic process
GO:0030814 regulation of cAMP metabolic process
GO:0030816 positive regulation of cAMP metabolic process
GO:0030817 regulation of cAMP biosynthetic process
GO:0030819 positive regulation of cAMP biosynthetic process
GO:0030879 mammary gland development
GO:0030900 forebrain development
GO:0031279 regulation of cyclase activity
GO:0031281 positive regulation of cyclase activity
GO:0031960 response to corticosteroid
GO:0032868 response to insulin
GO:0032869 cellular response to insulin stimulus
GO:0032941 secretion by tissue
GO:0033143 regulation of intracellular steroid hormone receptor signaling pathway
GO:0033500 carbohydrate homeostasis
GO:0034284 response to monosaccharide
GO:0035264 multicellular organism growth
GO:0035270 endocrine system development
GO:0040014 regulation of multicellular organism growth
GO:0040018 positive regulation of multicellular organism growth
GO:0042445 hormone metabolic process
GO:0042593 glucose homeostasis
GO:0042745 circadian sleep/wake cycle
GO:0042748 circadian sleep/wake cycle, non-REM sleep
GO:0042749 regulation of circadian sleep/wake cycle
GO:0042752 regulation of circadian rhythm
GO:0042753 positive regulation of circadian rhythm
GO:0042886 amide transport
GO:0043401 steroid hormone mediated signaling pathway
GO:0043434 response to peptide hormone
GO:0043567 regulation of insulin-like growth factor receptor signaling pathway
GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway
GO:0043627 response to estrogen
GO:0044708 single-organism behavior
GO:0045187 regulation of circadian sleep/wake cycle, sleep
GO:0045188 regulation of circadian sleep/wake cycle, non-REM sleep
GO:0045761 regulation of adenylate cyclase activity
GO:0045762 positive regulation of adenylate cyclase activity
GO:0045927 positive regulation of growth
GO:0045938 positive regulation of circadian sleep/wake cycle, sleep
GO:0045981 positive regulation of nucleotide metabolic process
GO:0046010 positive regulation of circadian sleep/wake cycle, non-REM sleep
GO:0046058 cAMP metabolic process
GO:0046390 ribose phosphate biosynthetic process
GO:0046879 hormone secretion
GO:0046883 regulation of hormone secretion
GO:0046887 positive regulation of hormone secretion
GO:0048009 insulin-like growth factor receptor signaling pathway
GO:0048469 cell maturation
GO:0048511 rhythmic process
GO:0048512 circadian behavior
GO:0048520 positive regulation of behavior
GO:0048545 response to steroid hormone
GO:0048638 regulation of developmental growth
GO:0048639 positive regulation of developmental growth
GO:0048732 gland development
GO:0050795 regulation of behavior
GO:0050802 circadian sleep/wake cycle, sleep
GO:0050878 regulation of body fluid levels
GO:0051047 positive regulation of secretion
GO:0051339 regulation of lyase activity
GO:0051349 positive regulation of lyase activity
GO:0051384 response to glucocorticoid
GO:0052652 cyclic purine nucleotide metabolic process
GO:0060123 regulation of growth hormone secretion
GO:0060124 positive regulation of growth hormone secretion
GO:0060126 somatotropin secreting cell differentiation
GO:0060133 somatotropin secreting cell development
GO:0071322 cellular response to carbohydrate stimulus
GO:0071326 cellular response to monosaccharide stimulus
GO:0071331 cellular response to hexose stimulus
GO:0071333 cellular response to glucose stimulus
GO:0071375 cellular response to peptide hormone stimulus
GO:0071383 cellular response to steroid hormone stimulus
GO:0071396 cellular response to lipid
GO:0071407 cellular response to organic cyclic compound
GO:0071417 cellular response to organonitrogen compound
GO:0072522 purine-containing compound biosynthetic process
GO:0090087 regulation of peptide transport
GO:0090276 regulation of peptide hormone secretion
GO:0090277 positive regulation of peptide hormone secretion
GO:1900371 regulation of purine nucleotide biosynthetic process
GO:1900373 positive regulation of purine nucleotide biosynthetic process
GO:1900542 regulation of purine nucleotide metabolic process
GO:1900544 positive regulation of purine nucleotide metabolic process
GO:1901293 nucleoside phosphate biosynthetic process
GO:1901652 response to peptide
GO:1901653 cellular response to peptide
GO:1903532 positive regulation of secretion by cell
Molecular Function GO:0016520 growth hormone-releasing hormone receptor activity
GO:0017046 peptide hormone binding
GO:0019838 growth factor binding
GO:0033218 amide binding
GO:0042277 peptide binding
GO:0042562 hormone binding
Cellular Component GO:0005635 nuclear envelope
GO:0005637 nuclear inner membrane
GO:0005640 nuclear outer membrane
GO:0016363 nuclear matrix
GO:0019867 outer membrane
GO:0030141 secretory granule
GO:0031965 nuclear membrane
GO:0031968 organelle outer membrane
GO:0034399 nuclear periphery
GO:0042383 sarcolemma
GO:0099503 secretory vesicle
> KEGG and Reactome Pathway
 
KEGG hsa04080 Neuroactive ligand-receptor interaction
Reactome R-HSA-373080: Class B/2 (Secretin family receptors)
R-HSA-418555: G alpha (s) signalling events
R-HSA-388396: GPCR downstream signaling
R-HSA-500792: GPCR ligand binding
R-HSA-420092: Glucagon-type ligand receptors
R-HSA-162582: Signal Transduction
R-HSA-372790: Signaling by GPCR
Summary
SymbolGHRHR
Namegrowth hormone releasing hormone receptor
Aliases GHRFR; GRFR; GHRH receptor; GRF receptor; Growth hormone-releasing factor receptor; Growth hormone-releasing ......
Chromosomal Location7p14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between GHRHR and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolGHRHR
Namegrowth hormone releasing hormone receptor
Aliases GHRFR; GRFR; GHRH receptor; GRF receptor; Growth hormone-releasing factor receptor; Growth hormone-releasing ......
Chromosomal Location7p14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of GHRHR in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA Resistant to T cell-mediated killing
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolGHRHR
Namegrowth hormone releasing hormone receptor
Aliases GHRFR; GRFR; GHRH receptor; GRF receptor; Growth hormone-releasing factor receptor; Growth hormone-releasing ......
Chromosomal Location7p14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of GHRHR in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)141201
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)6501
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)8701
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-1.360.124
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-3.1210.0109
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.8450.56
729033130MelanomaallAnti-PD-1 (nivolumab) 262301
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 151101
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 111201
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 4801
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 2801
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0040.99
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of GHRHR in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141705.9-5.91
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 41407.1-7.11
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.41.460.177
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 01407.1-7.11
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.407.40.096
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.16.24.91
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 592011.18.91
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 111307.7-7.71
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 51208.3-8.31
Summary
SymbolGHRHR
Namegrowth hormone releasing hormone receptor
Aliases GHRFR; GRFR; GHRH receptor; GRF receptor; Growth hormone-releasing factor receptor; Growth hormone-releasing ......
Chromosomal Location7p14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GHRHR. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolGHRHR
Namegrowth hormone releasing hormone receptor
Aliases GHRFR; GRFR; GHRH receptor; GRF receptor; Growth hormone-releasing factor receptor; Growth hormone-releasing ......
Chromosomal Location7p14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GHRHR. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GHRHR.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolGHRHR
Namegrowth hormone releasing hormone receptor
Aliases GHRFR; GRFR; GHRH receptor; GRF receptor; Growth hormone-releasing factor receptor; Growth hormone-releasing ......
Chromosomal Location7p14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GHRHR. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolGHRHR
Namegrowth hormone releasing hormone receptor
Aliases GHRFR; GRFR; GHRH receptor; GRF receptor; Growth hormone-releasing factor receptor; Growth hormone-releasing ......
Chromosomal Location7p14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of GHRHR expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolGHRHR
Namegrowth hormone releasing hormone receptor
Aliases GHRFR; GRFR; GHRH receptor; GRF receptor; Growth hormone-releasing factor receptor; Growth hormone-releasing ......
Chromosomal Location7p14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between GHRHR and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolGHRHR
Namegrowth hormone releasing hormone receptor
Aliases GHRFR; GRFR; GHRH receptor; GRF receptor; Growth hormone-releasing factor receptor; Growth hormone-releasing ......
Chromosomal Location7p14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting GHRHR collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting GHRHR.
ID Name Drug Type Targets #Targets
DB00010SermorelinBiotechGHRHR1
DB08869TesamorelinSmall MoleculeGHRHR1