Summary | |
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Symbol | GIGYF2 |
Name | GRB10 interacting GYF protein 2 |
Aliases | KIAA0642; GYF2; GYF domain containing 2; PERQ2; PERQ3; TNRC15; PERQ amino acid rich, with GYF domain 2; PERQ ...... |
Chromosomal Location | 2q37.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | - |
Domain |
PF02213 GYF domain |
Function |
Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation (PubMed:22751931). In 4EHP-GYF2 the complex, acts as a factor that bridges EIF4E2 to ZFP36/TTP, linking translation repression with mRNA decay (By similarity). May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors (PubMed:12771153). |
Biological Process |
GO:0000075 cell cycle checkpoint GO:0000077 DNA damage checkpoint GO:0000082 G1/S transition of mitotic cell cycle GO:0001894 tissue homeostasis GO:0006417 regulation of translation GO:0007093 mitotic cell cycle checkpoint GO:0007346 regulation of mitotic cell cycle GO:0007626 locomotory behavior GO:0007631 feeding behavior GO:0008344 adult locomotory behavior GO:0009791 post-embryonic development GO:0010608 posttranscriptional regulation of gene expression GO:0010948 negative regulation of cell cycle process GO:0017148 negative regulation of translation GO:0021510 spinal cord development GO:0021515 cell differentiation in spinal cord GO:0021517 ventral spinal cord development GO:0021522 spinal cord motor neuron differentiation GO:0021953 central nervous system neuron differentiation GO:0030534 adult behavior GO:0031570 DNA integrity checkpoint GO:0031571 mitotic G1 DNA damage checkpoint GO:0034248 regulation of cellular amide metabolic process GO:0034249 negative regulation of cellular amide metabolic process GO:0035264 multicellular organism growth GO:0044708 single-organism behavior GO:0044770 cell cycle phase transition GO:0044772 mitotic cell cycle phase transition GO:0044773 mitotic DNA damage checkpoint GO:0044774 mitotic DNA integrity checkpoint GO:0044783 G1 DNA damage checkpoint GO:0044819 mitotic G1/S transition checkpoint GO:0044843 cell cycle G1/S phase transition GO:0045786 negative regulation of cell cycle GO:0045930 negative regulation of mitotic cell cycle GO:0048009 insulin-like growth factor receptor signaling pathway GO:0048871 multicellular organismal homeostasis GO:0048872 homeostasis of number of cells GO:0048873 homeostasis of number of cells within a tissue GO:0050879 multicellular organismal movement GO:0050881 musculoskeletal movement GO:0050885 neuromuscular process controlling balance GO:0050905 neuromuscular process GO:0060249 anatomical structure homeostasis GO:1901987 regulation of cell cycle phase transition GO:1901988 negative regulation of cell cycle phase transition GO:1901990 regulation of mitotic cell cycle phase transition GO:1901991 negative regulation of mitotic cell cycle phase transition GO:1902806 regulation of cell cycle G1/S phase transition GO:1902807 negative regulation of cell cycle G1/S phase transition GO:2000045 regulation of G1/S transition of mitotic cell cycle GO:2000134 negative regulation of G1/S transition of mitotic cell cycle |
Molecular Function |
GO:0045296 cadherin binding GO:0050839 cell adhesion molecule binding GO:0098631 protein binding involved in cell adhesion GO:0098632 protein binding involved in cell-cell adhesion GO:0098641 cadherin binding involved in cell-cell adhesion |
Cellular Component |
GO:0005913 cell-cell adherens junction |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | GIGYF2 |
Name | GRB10 interacting GYF protein 2 |
Aliases | KIAA0642; GYF2; GYF domain containing 2; PERQ2; PERQ3; TNRC15; PERQ amino acid rich, with GYF domain 2; PERQ ...... |
Chromosomal Location | 2q37.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between GIGYF2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | GIGYF2 |
Name | GRB10 interacting GYF protein 2 |
Aliases | KIAA0642; GYF2; GYF domain containing 2; PERQ2; PERQ3; TNRC15; PERQ amino acid rich, with GYF domain 2; PERQ ...... |
Chromosomal Location | 2q37.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of GIGYF2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | GIGYF2 |
Name | GRB10 interacting GYF protein 2 |
Aliases | KIAA0642; GYF2; GYF domain containing 2; PERQ2; PERQ3; TNRC15; PERQ amino acid rich, with GYF domain 2; PERQ ...... |
Chromosomal Location | 2q37.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of GIGYF2 in various data sets.
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Points in the above scatter plot represent the mutation difference of GIGYF2 in various data sets.
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Summary | |
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Symbol | GIGYF2 |
Name | GRB10 interacting GYF protein 2 |
Aliases | KIAA0642; GYF2; GYF domain containing 2; PERQ2; PERQ3; TNRC15; PERQ amino acid rich, with GYF domain 2; PERQ ...... |
Chromosomal Location | 2q37.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GIGYF2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | GIGYF2 |
Name | GRB10 interacting GYF protein 2 |
Aliases | KIAA0642; GYF2; GYF domain containing 2; PERQ2; PERQ3; TNRC15; PERQ amino acid rich, with GYF domain 2; PERQ ...... |
Chromosomal Location | 2q37.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GIGYF2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GIGYF2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | GIGYF2 |
Name | GRB10 interacting GYF protein 2 |
Aliases | KIAA0642; GYF2; GYF domain containing 2; PERQ2; PERQ3; TNRC15; PERQ amino acid rich, with GYF domain 2; PERQ ...... |
Chromosomal Location | 2q37.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GIGYF2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | GIGYF2 |
Name | GRB10 interacting GYF protein 2 |
Aliases | KIAA0642; GYF2; GYF domain containing 2; PERQ2; PERQ3; TNRC15; PERQ amino acid rich, with GYF domain 2; PERQ ...... |
Chromosomal Location | 2q37.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of GIGYF2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | GIGYF2 |
Name | GRB10 interacting GYF protein 2 |
Aliases | KIAA0642; GYF2; GYF domain containing 2; PERQ2; PERQ3; TNRC15; PERQ amino acid rich, with GYF domain 2; PERQ ...... |
Chromosomal Location | 2q37.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between GIGYF2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | GIGYF2 |
Name | GRB10 interacting GYF protein 2 |
Aliases | KIAA0642; GYF2; GYF domain containing 2; PERQ2; PERQ3; TNRC15; PERQ amino acid rich, with GYF domain 2; PERQ ...... |
Chromosomal Location | 2q37.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting GIGYF2 collected from DrugBank database. |
There is no record. |