Summary | |
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Symbol | GIPR |
Name | gastric inhibitory polypeptide receptor |
Aliases | PGQTL2; GIP-R; glucose-dependent insulinotropic polypeptide receptor |
Chromosomal Location | 19q13.2-q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Domain |
PF00002 7 transmembrane receptor (Secretin family) PF02793 Hormone receptor domain |
Function |
This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. |
Biological Process |
GO:0001101 response to acid chemical GO:0002029 desensitization of G-protein coupled receptor protein signaling pathway GO:0002790 peptide secretion GO:0002791 regulation of peptide secretion GO:0002793 positive regulation of peptide secretion GO:0006091 generation of precursor metabolites and energy GO:0006140 regulation of nucleotide metabolic process GO:0006164 purine nucleotide biosynthetic process GO:0006171 cAMP biosynthetic process GO:0006874 cellular calcium ion homeostasis GO:0006875 cellular metal ion homeostasis GO:0007190 activation of adenylate cyclase activity GO:0007204 positive regulation of cytosolic calcium ion concentration GO:0007584 response to nutrient GO:0008277 regulation of G-protein coupled receptor protein signaling pathway GO:0009150 purine ribonucleotide metabolic process GO:0009152 purine ribonucleotide biosynthetic process GO:0009165 nucleotide biosynthetic process GO:0009187 cyclic nucleotide metabolic process GO:0009190 cyclic nucleotide biosynthetic process GO:0009260 ribonucleotide biosynthetic process GO:0009306 protein secretion GO:0009743 response to carbohydrate GO:0009746 response to hexose GO:0009749 response to glucose GO:0009914 hormone transport GO:0009991 response to extracellular stimulus GO:0010035 response to inorganic substance GO:0010038 response to metal ion GO:0010817 regulation of hormone levels GO:0015833 peptide transport GO:0022401 negative adaptation of signaling pathway GO:0023058 adaptation of signaling pathway GO:0023061 signal release GO:0030072 peptide hormone secretion GO:0030073 insulin secretion GO:0030799 regulation of cyclic nucleotide metabolic process GO:0030801 positive regulation of cyclic nucleotide metabolic process GO:0030802 regulation of cyclic nucleotide biosynthetic process GO:0030804 positive regulation of cyclic nucleotide biosynthetic process GO:0030808 regulation of nucleotide biosynthetic process GO:0030810 positive regulation of nucleotide biosynthetic process GO:0030814 regulation of cAMP metabolic process GO:0030816 positive regulation of cAMP metabolic process GO:0030817 regulation of cAMP biosynthetic process GO:0030819 positive regulation of cAMP biosynthetic process GO:0031016 pancreas development GO:0031018 endocrine pancreas development GO:0031279 regulation of cyclase activity GO:0031281 positive regulation of cyclase activity GO:0031667 response to nutrient levels GO:0032024 positive regulation of insulin secretion GO:0034284 response to monosaccharide GO:0035270 endocrine system development GO:0038192 gastric inhibitory peptide signaling pathway GO:0042886 amide transport GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway GO:0045761 regulation of adenylate cyclase activity GO:0045762 positive regulation of adenylate cyclase activity GO:0045981 positive regulation of nucleotide metabolic process GO:0046058 cAMP metabolic process GO:0046390 ribose phosphate biosynthetic process GO:0046879 hormone secretion GO:0046883 regulation of hormone secretion GO:0046887 positive regulation of hormone secretion GO:0048678 response to axon injury GO:0050708 regulation of protein secretion GO:0050714 positive regulation of protein secretion GO:0050796 regulation of insulin secretion GO:0051047 positive regulation of secretion GO:0051222 positive regulation of protein transport GO:0051339 regulation of lyase activity GO:0051349 positive regulation of lyase activity GO:0051480 regulation of cytosolic calcium ion concentration GO:0051592 response to calcium ion GO:0052652 cyclic purine nucleotide metabolic process GO:0055074 calcium ion homeostasis GO:0070542 response to fatty acid GO:0072503 cellular divalent inorganic cation homeostasis GO:0072507 divalent inorganic cation homeostasis GO:0072522 purine-containing compound biosynthetic process GO:0090087 regulation of peptide transport GO:0090276 regulation of peptide hormone secretion GO:0090277 positive regulation of peptide hormone secretion GO:1900371 regulation of purine nucleotide biosynthetic process GO:1900373 positive regulation of purine nucleotide biosynthetic process GO:1900542 regulation of purine nucleotide metabolic process GO:1900544 positive regulation of purine nucleotide metabolic process GO:1901293 nucleoside phosphate biosynthetic process GO:1903532 positive regulation of secretion by cell GO:1904951 positive regulation of establishment of protein localization |
Molecular Function |
GO:0016519 gastric inhibitory peptide receptor activity GO:0017046 peptide hormone binding GO:0033218 amide binding GO:0042277 peptide binding GO:0042562 hormone binding |
Cellular Component | - |
KEGG |
hsa04024 cAMP signaling pathway hsa04080 Neuroactive ligand-receptor interaction |
Reactome |
R-HSA-373080: Class B/2 (Secretin family receptors) R-HSA-418555: G alpha (s) signalling events R-HSA-388396: GPCR downstream signaling R-HSA-500792: GPCR ligand binding R-HSA-420092: Glucagon-type ligand receptors R-HSA-162582: Signal Transduction R-HSA-372790: Signaling by GPCR |
Summary | |
---|---|
Symbol | GIPR |
Name | gastric inhibitory polypeptide receptor |
Aliases | PGQTL2; GIP-R; glucose-dependent insulinotropic polypeptide receptor |
Chromosomal Location | 19q13.2-q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between GIPR and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | GIPR |
Name | gastric inhibitory polypeptide receptor |
Aliases | PGQTL2; GIP-R; glucose-dependent insulinotropic polypeptide receptor |
Chromosomal Location | 19q13.2-q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of GIPR in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | GIPR |
Name | gastric inhibitory polypeptide receptor |
Aliases | PGQTL2; GIP-R; glucose-dependent insulinotropic polypeptide receptor |
Chromosomal Location | 19q13.2-q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of GIPR in various data sets.
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There is no record. |
Summary | |
---|---|
Symbol | GIPR |
Name | gastric inhibitory polypeptide receptor |
Aliases | PGQTL2; GIP-R; glucose-dependent insulinotropic polypeptide receptor |
Chromosomal Location | 19q13.2-q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GIPR. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | GIPR |
Name | gastric inhibitory polypeptide receptor |
Aliases | PGQTL2; GIP-R; glucose-dependent insulinotropic polypeptide receptor |
Chromosomal Location | 19q13.2-q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GIPR. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GIPR. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | GIPR |
Name | gastric inhibitory polypeptide receptor |
Aliases | PGQTL2; GIP-R; glucose-dependent insulinotropic polypeptide receptor |
Chromosomal Location | 19q13.2-q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GIPR. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | GIPR |
Name | gastric inhibitory polypeptide receptor |
Aliases | PGQTL2; GIP-R; glucose-dependent insulinotropic polypeptide receptor |
Chromosomal Location | 19q13.2-q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of GIPR expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | GIPR |
Name | gastric inhibitory polypeptide receptor |
Aliases | PGQTL2; GIP-R; glucose-dependent insulinotropic polypeptide receptor |
Chromosomal Location | 19q13.2-q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between GIPR and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | GIPR |
Name | gastric inhibitory polypeptide receptor |
Aliases | PGQTL2; GIP-R; glucose-dependent insulinotropic polypeptide receptor |
Chromosomal Location | 19q13.2-q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting GIPR collected from DrugBank database. |
There is no record. |