Browse GJA1

Summary
SymbolGJA1
Namegap junction protein, alpha 1, 43kDa
Aliases CX43; ODOD; SDTY3; oculodentodigital dysplasia (syndactyly type III); connexin 43; ODDD; GJAL; gap junction ......
Chromosomal Location6q22.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane Multi-pass membrane protein Cell junction, gap junction Endoplasmic reticulum Note=Localizes at the intercalated disk (ICD) in cardiomyocytes and the proper localization at ICD is dependent on TMEM65.
Domain PF00029 Connexin
PF03508 Gap junction alpha-1 protein (Cx43)
Function

Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity). May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles (By similarity).

> Gene Ontology
 
Biological Process GO:0001503 ossification
GO:0001508 action potential
GO:0001558 regulation of cell growth
GO:0001649 osteoblast differentiation
GO:0001654 eye development
GO:0001662 behavioral fear response
GO:0001701 in utero embryonic development
GO:0001764 neuron migration
GO:0001935 endothelial cell proliferation
GO:0001936 regulation of endothelial cell proliferation
GO:0001937 negative regulation of endothelial cell proliferation
GO:0001947 heart looping
GO:0001977 renal system process involved in regulation of blood volume
GO:0002064 epithelial cell development
GO:0002070 epithelial cell maturation
GO:0002088 lens development in camera-type eye
GO:0002209 behavioral defense response
GO:0002544 chronic inflammatory response
GO:0002790 peptide secretion
GO:0002791 regulation of peptide secretion
GO:0002793 positive regulation of peptide secretion
GO:0003007 heart morphogenesis
GO:0003012 muscle system process
GO:0003013 circulatory system process
GO:0003014 renal system process
GO:0003015 heart process
GO:0003018 vascular process in circulatory system
GO:0003071 renal system process involved in regulation of systemic arterial blood pressure
GO:0003073 regulation of systemic arterial blood pressure
GO:0003093 regulation of glomerular filtration
GO:0003094 glomerular filtration
GO:0003104 positive regulation of glomerular filtration
GO:0003143 embryonic heart tube morphogenesis
GO:0003158 endothelium development
GO:0003254 regulation of membrane depolarization
GO:0003294 atrial ventricular junction remodeling
GO:0006816 calcium ion transport
GO:0006862 nucleotide transport
GO:0006874 cellular calcium ion homeostasis
GO:0006875 cellular metal ion homeostasis
GO:0006936 muscle contraction
GO:0006941 striated muscle contraction
GO:0007043 cell-cell junction assembly
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0007368 determination of left/right symmetry
GO:0007389 pattern specification process
GO:0007423 sensory organ development
GO:0007507 heart development
GO:0007512 adult heart development
GO:0007517 muscle organ development
GO:0008015 blood circulation
GO:0008016 regulation of heart contraction
GO:0008217 regulation of blood pressure
GO:0009268 response to pH
GO:0009306 protein secretion
GO:0009612 response to mechanical stimulus
GO:0009743 response to carbohydrate
GO:0009746 response to hexose
GO:0009749 response to glucose
GO:0009799 specification of symmetry
GO:0009855 determination of bilateral symmetry
GO:0009894 regulation of catabolic process
GO:0009896 positive regulation of catabolic process
GO:0009914 hormone transport
GO:0010232 vascular transport
GO:0010643 cell communication by chemical coupling
GO:0010644 cell communication by electrical coupling
GO:0010645 regulation of cell communication by chemical coupling
GO:0010652 positive regulation of cell communication by chemical coupling
GO:0010817 regulation of hormone levels
GO:0010959 regulation of metal ion transport
GO:0014706 striated muscle tissue development
GO:0014855 striated muscle cell proliferation
GO:0015748 organophosphate ester transport
GO:0015833 peptide transport
GO:0015858 nucleoside transport
GO:0015865 purine nucleotide transport
GO:0015867 ATP transport
GO:0015868 purine ribonucleotide transport
GO:0015931 nucleobase-containing compound transport
GO:0016049 cell growth
GO:0016202 regulation of striated muscle tissue development
GO:0016264 gap junction assembly
GO:0019229 regulation of vasoconstriction
GO:0021700 developmental maturation
GO:0023061 signal release
GO:0030048 actin filament-based movement
GO:0030072 peptide hormone secretion
GO:0030073 insulin secretion
GO:0030278 regulation of ossification
GO:0030282 bone mineralization
GO:0030308 negative regulation of cell growth
GO:0030326 embryonic limb morphogenesis
GO:0030500 regulation of bone mineralization
GO:0031099 regeneration
GO:0031214 biomineral tissue development
GO:0031349 positive regulation of defense response
GO:0032024 positive regulation of insulin secretion
GO:0032102 negative regulation of response to external stimulus
GO:0032844 regulation of homeostatic process
GO:0033002 muscle cell proliferation
GO:0033555 multicellular organismal response to stress
GO:0034103 regulation of tissue remodeling
GO:0034284 response to monosaccharide
GO:0034329 cell junction assembly
GO:0034330 cell junction organization
GO:0034405 response to fluid shear stress
GO:0034762 regulation of transmembrane transport
GO:0034765 regulation of ion transmembrane transport
GO:0035050 embryonic heart tube development
GO:0035107 appendage morphogenesis
GO:0035108 limb morphogenesis
GO:0035113 embryonic appendage morphogenesis
GO:0035150 regulation of tube size
GO:0035239 tube morphogenesis
GO:0035265 organ growth
GO:0035637 multicellular organismal signaling
GO:0042176 regulation of protein catabolic process
GO:0042246 tissue regeneration
GO:0042310 vasoconstriction
GO:0042311 vasodilation
GO:0042312 regulation of vasodilation
GO:0042391 regulation of membrane potential
GO:0042596 fear response
GO:0042733 embryonic digit morphogenesis
GO:0042886 amide transport
GO:0043010 camera-type eye development
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043297 apical junction assembly
GO:0043403 skeletal muscle tissue regeneration
GO:0043434 response to peptide hormone
GO:0044057 regulation of system process
GO:0044708 single-organism behavior
GO:0045216 cell-cell junction organization
GO:0045667 regulation of osteoblast differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0045732 positive regulation of protein catabolic process
GO:0045778 positive regulation of ossification
GO:0045843 negative regulation of striated muscle tissue development
GO:0045844 positive regulation of striated muscle tissue development
GO:0045907 positive regulation of vasoconstriction
GO:0045909 positive regulation of vasodilation
GO:0045926 negative regulation of growth
GO:0046620 regulation of organ growth
GO:0046621 negative regulation of organ growth
GO:0046849 bone remodeling
GO:0046850 regulation of bone remodeling
GO:0046879 hormone secretion
GO:0046883 regulation of hormone secretion
GO:0046887 positive regulation of hormone secretion
GO:0048469 cell maturation
GO:0048514 blood vessel morphogenesis
GO:0048520 positive regulation of behavior
GO:0048562 embryonic organ morphogenesis
GO:0048568 embryonic organ development
GO:0048634 regulation of muscle organ development
GO:0048635 negative regulation of muscle organ development
GO:0048636 positive regulation of muscle organ development
GO:0048638 regulation of developmental growth
GO:0048640 negative regulation of developmental growth
GO:0048736 appendage development
GO:0048738 cardiac muscle tissue development
GO:0048771 tissue remodeling
GO:0050673 epithelial cell proliferation
GO:0050678 regulation of epithelial cell proliferation
GO:0050680 negative regulation of epithelial cell proliferation
GO:0050708 regulation of protein secretion
GO:0050714 positive regulation of protein secretion
GO:0050795 regulation of behavior
GO:0050796 regulation of insulin secretion
GO:0050878 regulation of body fluid levels
GO:0050880 regulation of blood vessel size
GO:0051047 positive regulation of secretion
GO:0051052 regulation of DNA metabolic process
GO:0051053 negative regulation of DNA metabolic process
GO:0051222 positive regulation of protein transport
GO:0051259 protein oligomerization
GO:0051480 regulation of cytosolic calcium ion concentration
GO:0051503 adenine nucleotide transport
GO:0051899 membrane depolarization
GO:0051924 regulation of calcium ion transport
GO:0055017 cardiac muscle tissue growth
GO:0055021 regulation of cardiac muscle tissue growth
GO:0055022 negative regulation of cardiac muscle tissue growth
GO:0055024 regulation of cardiac muscle tissue development
GO:0055026 negative regulation of cardiac muscle tissue development
GO:0055074 calcium ion homeostasis
GO:0060004 reflex
GO:0060038 cardiac muscle cell proliferation
GO:0060043 regulation of cardiac muscle cell proliferation
GO:0060044 negative regulation of cardiac muscle cell proliferation
GO:0060047 heart contraction
GO:0060048 cardiac muscle contraction
GO:0060156 milk ejection
GO:0060173 limb development
GO:0060306 regulation of membrane repolarization
GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization
GO:0060371 regulation of atrial cardiac muscle cell membrane depolarization
GO:0060373 regulation of ventricular cardiac muscle cell membrane depolarization
GO:0060419 heart growth
GO:0060420 regulation of heart growth
GO:0060537 muscle tissue development
GO:0060562 epithelial tube morphogenesis
GO:0061041 regulation of wound healing
GO:0061045 negative regulation of wound healing
GO:0061117 negative regulation of heart growth
GO:0061337 cardiac conduction
GO:0061371 determination of heart left/right asymmetry
GO:0070167 regulation of biomineral tissue development
GO:0070252 actin-mediated cell contraction
GO:0070830 bicellular tight junction assembly
GO:0070838 divalent metal ion transport
GO:0071214 cellular response to abiotic stimulus
GO:0071260 cellular response to mechanical stimulus
GO:0071496 cellular response to external stimulus
GO:0071897 DNA biosynthetic process
GO:0072503 cellular divalent inorganic cation homeostasis
GO:0072507 divalent inorganic cation homeostasis
GO:0072511 divalent inorganic cation transport
GO:0086001 cardiac muscle cell action potential
GO:0086002 cardiac muscle cell action potential involved in contraction
GO:0086003 cardiac muscle cell contraction
GO:0086009 membrane repolarization
GO:0086014 atrial cardiac muscle cell action potential
GO:0086019 cell-cell signaling involved in cardiac conduction
GO:0086026 atrial cardiac muscle cell to AV node cell signaling
GO:0086064 cell communication by electrical coupling involved in cardiac conduction
GO:0086065 cell communication involved in cardiac conduction
GO:0086066 atrial cardiac muscle cell to AV node cell communication
GO:0090066 regulation of anatomical structure size
GO:0090087 regulation of peptide transport
GO:0090276 regulation of peptide hormone secretion
GO:0090277 positive regulation of peptide hormone secretion
GO:0097205 renal filtration
GO:0098801 regulation of renal system process
GO:0099622 cardiac muscle cell membrane repolarization
GO:0099623 regulation of cardiac muscle cell membrane repolarization
GO:0099625 ventricular cardiac muscle cell membrane repolarization
GO:1901264 carbohydrate derivative transport
GO:1901652 response to peptide
GO:1901861 regulation of muscle tissue development
GO:1901862 negative regulation of muscle tissue development
GO:1901863 positive regulation of muscle tissue development
GO:1901888 regulation of cell junction assembly
GO:1903034 regulation of response to wounding
GO:1903035 negative regulation of response to wounding
GO:1903365 regulation of fear response
GO:1903367 positive regulation of fear response
GO:1903522 regulation of blood circulation
GO:1903524 positive regulation of blood circulation
GO:1903532 positive regulation of secretion by cell
GO:1904951 positive regulation of establishment of protein localization
GO:2000021 regulation of ion homeostasis
GO:2000278 regulation of DNA biosynthetic process
GO:2000279 negative regulation of DNA biosynthetic process
GO:2000810 regulation of bicellular tight junction assembly
GO:2000822 regulation of behavioral fear response
GO:2000987 positive regulation of behavioral fear response
Molecular Function GO:0005243 gap junction channel activity
GO:0015267 channel activity
GO:0015631 tubulin binding
GO:0017124 SH3 domain binding
GO:0022803 passive transmembrane transporter activity
GO:0022829 wide pore channel activity
GO:0030165 PDZ domain binding
GO:0048487 beta-tubulin binding
GO:0071253 connexin binding
GO:0086075 gap junction channel activity involved in cardiac conduction electrical coupling
GO:0097110 scaffold protein binding
GO:1903763 gap junction channel activity involved in cell communication by electrical coupling
Cellular Component GO:0005741 mitochondrial outer membrane
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005771 multivesicular body
GO:0005798 Golgi-associated vesicle
GO:0005882 intermediate filament
GO:0005913 cell-cell adherens junction
GO:0005916 fascia adherens
GO:0005921 gap junction
GO:0005922 connexin complex
GO:0005924 cell-substrate adherens junction
GO:0005925 focal adhesion
GO:0014704 intercalated disc
GO:0016324 apical plasma membrane
GO:0016328 lateral plasma membrane
GO:0019867 outer membrane
GO:0030055 cell-substrate junction
GO:0030660 Golgi-associated vesicle membrane
GO:0031968 organelle outer membrane
GO:0043292 contractile fiber
GO:0044291 cell-cell contact zone
GO:0045111 intermediate filament cytoskeleton
GO:0045121 membrane raft
GO:0045177 apical part of cell
GO:0098589 membrane region
GO:0098857 membrane microdomain
> KEGG and Reactome Pathway
 
KEGG hsa04540 Gap junction
Reactome R-HSA-196025: Formation of annular gap junctions
R-HSA-190861: Gap junction assembly
R-HSA-190873: Gap junction degradation
R-HSA-190828: Gap junction trafficking
R-HSA-157858: Gap junction trafficking and regulation
R-HSA-199991: Membrane Trafficking
R-HSA-190840: Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
R-HSA-190704: Oligomerization of connexins into connexons
R-HSA-191650: Regulation of gap junction activity
R-HSA-190827: Transport of connexins along the secretory pathway
R-HSA-190872: Transport of connexons to the plasma membrane
R-HSA-5653656: Vesicle-mediated transport
R-HSA-191647: c-src mediated regulation of Cx43 function and closure of gap junctions
Summary
SymbolGJA1
Namegap junction protein, alpha 1, 43kDa
Aliases CX43; ODOD; SDTY3; oculodentodigital dysplasia (syndactyly type III); connexin 43; ODDD; GJAL; gap junction ......
Chromosomal Location6q22.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between GJA1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between GJA1 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
26221040MelanomaPromote immunity (NK cell function)The Selective Degradation of Synaptic Connexin 43 Protein by Hypoxia-induced Autophagy Impairs Natural Killer Cell-mediated Tumor Cell Killing.
Summary
SymbolGJA1
Namegap junction protein, alpha 1, 43kDa
Aliases CX43; ODOD; SDTY3; oculodentodigital dysplasia (syndactyly type III); connexin 43; ODDD; GJAL; gap junction ......
Chromosomal Location6q22.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of GJA1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolGJA1
Namegap junction protein, alpha 1, 43kDa
Aliases CX43; ODOD; SDTY3; oculodentodigital dysplasia (syndactyly type III); connexin 43; ODDD; GJAL; gap junction ......
Chromosomal Location6q22.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of GJA1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.4010.52
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.6830.738
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.1750.891
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.5580.239
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.7510.708
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.320.893
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.4130.481
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.3930.818
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.4550.81
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.4670.789
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.0870.651
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.4170.0229
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of GJA1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277302.7-2.71
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275903.4-3.41
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 382703.7-3.70.415
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 221307.7-7.70.371
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolGJA1
Namegap junction protein, alpha 1, 43kDa
Aliases CX43; ODOD; SDTY3; oculodentodigital dysplasia (syndactyly type III); connexin 43; ODDD; GJAL; gap junction ......
Chromosomal Location6q22.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GJA1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolGJA1
Namegap junction protein, alpha 1, 43kDa
Aliases CX43; ODOD; SDTY3; oculodentodigital dysplasia (syndactyly type III); connexin 43; ODDD; GJAL; gap junction ......
Chromosomal Location6q22.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GJA1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GJA1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolGJA1
Namegap junction protein, alpha 1, 43kDa
Aliases CX43; ODOD; SDTY3; oculodentodigital dysplasia (syndactyly type III); connexin 43; ODDD; GJAL; gap junction ......
Chromosomal Location6q22.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GJA1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolGJA1
Namegap junction protein, alpha 1, 43kDa
Aliases CX43; ODOD; SDTY3; oculodentodigital dysplasia (syndactyly type III); connexin 43; ODDD; GJAL; gap junction ......
Chromosomal Location6q22.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of GJA1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolGJA1
Namegap junction protein, alpha 1, 43kDa
Aliases CX43; ODOD; SDTY3; oculodentodigital dysplasia (syndactyly type III); connexin 43; ODDD; GJAL; gap junction ......
Chromosomal Location6q22.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between GJA1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolGJA1
Namegap junction protein, alpha 1, 43kDa
Aliases CX43; ODOD; SDTY3; oculodentodigital dysplasia (syndactyly type III); connexin 43; ODDD; GJAL; gap junction ......
Chromosomal Location6q22.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting GJA1 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting GJA1.
ID Name Drug Type Targets #Targets
DB01136CarvedilolSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, GJA1 ......17