Summary | |
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Symbol | GJB4 |
Name | gap junction protein, beta 4, 30.3kDa |
Aliases | CX30.3; connexin 30.3; gap junction protein, beta 4 (connexin 30.3); gap junction protein, beta 4; connexin- ...... |
Chromosomal Location | 1p35-p34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane; Multi-pass membrane protein. Cell junction, gap junction. |
Domain |
PF00029 Connexin |
Function |
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. |
Biological Process |
GO:0007608 sensory perception of smell GO:0007635 chemosensory behavior GO:0042048 olfactory behavior GO:0044708 single-organism behavior |
Molecular Function | - |
Cellular Component |
GO:0005921 gap junction GO:0005922 connexin complex |
KEGG | - |
Reactome |
R-HSA-190861: Gap junction assembly R-HSA-190828: Gap junction trafficking R-HSA-157858: Gap junction trafficking and regulation R-HSA-199991: Membrane Trafficking R-HSA-5653656: Vesicle-mediated transport |
Summary | |
---|---|
Symbol | GJB4 |
Name | gap junction protein, beta 4, 30.3kDa |
Aliases | CX30.3; connexin 30.3; gap junction protein, beta 4 (connexin 30.3); gap junction protein, beta 4; connexin- ...... |
Chromosomal Location | 1p35-p34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between GJB4 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | GJB4 |
Name | gap junction protein, beta 4, 30.3kDa |
Aliases | CX30.3; connexin 30.3; gap junction protein, beta 4 (connexin 30.3); gap junction protein, beta 4; connexin- ...... |
Chromosomal Location | 1p35-p34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of GJB4 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | GJB4 |
Name | gap junction protein, beta 4, 30.3kDa |
Aliases | CX30.3; connexin 30.3; gap junction protein, beta 4 (connexin 30.3); gap junction protein, beta 4; connexin- ...... |
Chromosomal Location | 1p35-p34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of GJB4 in various data sets.
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Points in the above scatter plot represent the mutation difference of GJB4 in various data sets.
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Summary | |
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Symbol | GJB4 |
Name | gap junction protein, beta 4, 30.3kDa |
Aliases | CX30.3; connexin 30.3; gap junction protein, beta 4 (connexin 30.3); gap junction protein, beta 4; connexin- ...... |
Chromosomal Location | 1p35-p34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GJB4. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | GJB4 |
Name | gap junction protein, beta 4, 30.3kDa |
Aliases | CX30.3; connexin 30.3; gap junction protein, beta 4 (connexin 30.3); gap junction protein, beta 4; connexin- ...... |
Chromosomal Location | 1p35-p34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GJB4. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GJB4. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | GJB4 |
Name | gap junction protein, beta 4, 30.3kDa |
Aliases | CX30.3; connexin 30.3; gap junction protein, beta 4 (connexin 30.3); gap junction protein, beta 4; connexin- ...... |
Chromosomal Location | 1p35-p34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GJB4. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | GJB4 |
Name | gap junction protein, beta 4, 30.3kDa |
Aliases | CX30.3; connexin 30.3; gap junction protein, beta 4 (connexin 30.3); gap junction protein, beta 4; connexin- ...... |
Chromosomal Location | 1p35-p34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of GJB4 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | GJB4 |
Name | gap junction protein, beta 4, 30.3kDa |
Aliases | CX30.3; connexin 30.3; gap junction protein, beta 4 (connexin 30.3); gap junction protein, beta 4; connexin- ...... |
Chromosomal Location | 1p35-p34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between GJB4 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | GJB4 |
Name | gap junction protein, beta 4, 30.3kDa |
Aliases | CX30.3; connexin 30.3; gap junction protein, beta 4 (connexin 30.3); gap junction protein, beta 4; connexin- ...... |
Chromosomal Location | 1p35-p34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting GJB4 collected from DrugBank database. |
There is no record. |