Summary | |
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Symbol | GLB1 |
Name | galactosidase, beta 1 |
Aliases | ELNR1; elastin receptor 1, 67kDa; elastin receptor 1 (67kD); MPS4B; acid beta-galactosidase; Elastin recepto ...... |
Chromosomal Location | 3p22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Isoform 1: Lysosome ; SUBCELLULAR LOCATION: Isoform 2: Cytoplasm, perinuclear region Note=Localized to the perinuclear area of the cytoplasm but not to lysosomes. |
Domain |
PF13364 Beta-galactosidase jelly roll domain PF01301 Glycosyl hydrolases family 35 |
Function |
Isoform 1: Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans. ; FUNCTION: Isoform 2: Has no beta-galactosidase catalytic activity, but plays functional roles in the formation of extracellular elastic fibers (elastogenesis) and in the development of connective tissue. Seems to be identical to the elastin-binding protein (EBP), a major component of the non-integrin cell surface receptor expressed on fibroblasts, smooth muscle cells, chondroblasts, leukocytes, and certain cancer cell types. In elastin producing cells, associates with tropoelastin intracellularly and functions as a recycling molecular chaperone which facilitates the secretions of tropoelastin and its assembly into elastic fibers. |
Biological Process |
GO:0005996 monosaccharide metabolic process GO:0006012 galactose metabolic process GO:0006022 aminoglycan metabolic process GO:0006026 aminoglycan catabolic process GO:0006027 glycosaminoglycan catabolic process GO:0006643 membrane lipid metabolic process GO:0006664 glycolipid metabolic process GO:0006665 sphingolipid metabolic process GO:0006687 glycosphingolipid metabolic process GO:0006790 sulfur compound metabolic process GO:0016052 carbohydrate catabolic process GO:0019318 hexose metabolic process GO:0019320 hexose catabolic process GO:0019388 galactose catabolic process GO:0030203 glycosaminoglycan metabolic process GO:0042339 keratan sulfate metabolic process GO:0042340 keratan sulfate catabolic process GO:0044262 cellular carbohydrate metabolic process GO:0044273 sulfur compound catabolic process GO:0044282 small molecule catabolic process GO:0044723 single-organism carbohydrate metabolic process GO:0044724 single-organism carbohydrate catabolic process GO:0046365 monosaccharide catabolic process GO:1901136 carbohydrate derivative catabolic process GO:1901565 organonitrogen compound catabolic process GO:1903509 liposaccharide metabolic process GO:1903510 mucopolysaccharide metabolic process |
Molecular Function |
GO:0004308 exo-alpha-sialidase activity GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GO:0004565 beta-galactosidase activity GO:0015925 galactosidase activity GO:0016798 hydrolase activity, acting on glycosyl bonds GO:0016936 galactoside binding GO:0016997 alpha-sialidase activity |
Cellular Component |
GO:0005775 vacuolar lumen GO:0043202 lysosomal lumen |
KEGG |
hsa04142 Lysosome hsa00052 Galactose metabolism hsa00511 Other glycan degradation hsa00531 Glycosaminoglycan degradation hsa00600 Sphingolipid metabolism hsa00604 Glycosphingolipid biosynthesis - ganglio series hsa01100 Metabolic pathways |
Reactome |
R-HSA-446203: Asparagine N-linked glycosylation R-HSA-446193: Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-1630316: Glycosaminoglycan metabolism R-HSA-1660662: Glycosphingolipid metabolism R-HSA-2024096: HS-GAG degradation R-HSA-1638091: Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-2022857: Keratan sulfate degradation R-HSA-1638074: Keratan sulfate/keratin metabolism R-HSA-1430728: Metabolism R-HSA-71387: Metabolism of carbohydrates R-HSA-556833: Metabolism of lipids and lipoproteins R-HSA-392499: Metabolism of proteins R-HSA-6798695: Neutrophil degranulation R-HSA-597592: Post-translational protein modification R-HSA-4085001: Sialic acid metabolism R-HSA-428157: Sphingolipid metabolism R-HSA-446219: Synthesis of substrates in N-glycan biosythesis |
Summary | |
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Symbol | GLB1 |
Name | galactosidase, beta 1 |
Aliases | ELNR1; elastin receptor 1, 67kDa; elastin receptor 1 (67kD); MPS4B; acid beta-galactosidase; Elastin recepto ...... |
Chromosomal Location | 3p22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between GLB1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between GLB1 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | GLB1 |
Name | galactosidase, beta 1 |
Aliases | ELNR1; elastin receptor 1, 67kDa; elastin receptor 1 (67kD); MPS4B; acid beta-galactosidase; Elastin recepto ...... |
Chromosomal Location | 3p22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of GLB1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | GLB1 |
Name | galactosidase, beta 1 |
Aliases | ELNR1; elastin receptor 1, 67kDa; elastin receptor 1 (67kD); MPS4B; acid beta-galactosidase; Elastin recepto ...... |
Chromosomal Location | 3p22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of GLB1 in various data sets.
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Points in the above scatter plot represent the mutation difference of GLB1 in various data sets.
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Summary | |
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Symbol | GLB1 |
Name | galactosidase, beta 1 |
Aliases | ELNR1; elastin receptor 1, 67kDa; elastin receptor 1 (67kD); MPS4B; acid beta-galactosidase; Elastin recepto ...... |
Chromosomal Location | 3p22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GLB1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | GLB1 |
Name | galactosidase, beta 1 |
Aliases | ELNR1; elastin receptor 1, 67kDa; elastin receptor 1 (67kD); MPS4B; acid beta-galactosidase; Elastin recepto ...... |
Chromosomal Location | 3p22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GLB1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GLB1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | GLB1 |
Name | galactosidase, beta 1 |
Aliases | ELNR1; elastin receptor 1, 67kDa; elastin receptor 1 (67kD); MPS4B; acid beta-galactosidase; Elastin recepto ...... |
Chromosomal Location | 3p22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GLB1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | GLB1 |
Name | galactosidase, beta 1 |
Aliases | ELNR1; elastin receptor 1, 67kDa; elastin receptor 1 (67kD); MPS4B; acid beta-galactosidase; Elastin recepto ...... |
Chromosomal Location | 3p22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of GLB1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | GLB1 |
Name | galactosidase, beta 1 |
Aliases | ELNR1; elastin receptor 1, 67kDa; elastin receptor 1 (67kD); MPS4B; acid beta-galactosidase; Elastin recepto ...... |
Chromosomal Location | 3p22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between GLB1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | GLB1 |
Name | galactosidase, beta 1 |
Aliases | ELNR1; elastin receptor 1, 67kDa; elastin receptor 1 (67kD); MPS4B; acid beta-galactosidase; Elastin recepto ...... |
Chromosomal Location | 3p22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting GLB1 collected from DrugBank database. |
There is no record. |