Summary | |
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Symbol | GLI1 |
Name | GLI family zinc finger 1 |
Aliases | GLI; glioma-associated oncogene homolog 1 (zinc finger protein); glioma-associated oncogene family zinc fing ...... |
Chromosomal Location | 12q13.2-q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Nucleus Note=Tethered in the cytoplasm by binding to SUFU (PubMed:10806483). Activation and translocation to the nucleus is promoted by interaction with STK36 (PubMed:10806483). Phosphorylation by ULK3 may promote nuclear localization (PubMed:19878745). Translocation to the nucleus is promoted by interaction with ZIC1 (PubMed:11238441). ; SUBCELLULAR LOCATION: Isoform 2: Cytoplasm Nucleus |
Domain | - |
Function |
Acts as a transcriptional activator (PubMed:19706761, PubMed:10806483, PubMed:19878745, PubMed:24311597, PubMed:24217340). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:2105456, PubMed:8378770, PubMed:24217340). May regulate the transcription of specific genes during normal development (PubMed:19706761). May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761). Plays a role in cell proliferation and differentiation via its role in SHH signaling (Probable). ; FUNCTION: Isoform 2: Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration. |
Biological Process |
GO:0001503 ossification GO:0001649 osteoblast differentiation GO:0001889 liver development GO:0003002 regionalization GO:0006260 DNA replication GO:0006275 regulation of DNA replication GO:0007224 smoothened signaling pathway GO:0007283 spermatogenesis GO:0007389 pattern specification process GO:0007418 ventral midline development GO:0008544 epidermis development GO:0008589 regulation of smoothened signaling pathway GO:0009913 epidermal cell differentiation GO:0009953 dorsal/ventral pattern formation GO:0009954 proximal/distal pattern formation GO:0016055 Wnt signaling pathway GO:0021536 diencephalon development GO:0021549 cerebellum development GO:0021575 hindbrain morphogenesis GO:0021587 cerebellum morphogenesis GO:0021695 cerebellar cortex development GO:0021696 cerebellar cortex morphogenesis GO:0021936 regulation of cerebellar granule cell precursor proliferation GO:0021937 cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation GO:0021938 smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation GO:0021940 positive regulation of cerebellar granule cell precursor proliferation GO:0021983 pituitary gland development GO:0022037 metencephalon development GO:0022612 gland morphogenesis GO:0030111 regulation of Wnt signaling pathway GO:0030178 negative regulation of Wnt signaling pathway GO:0030278 regulation of ossification GO:0030323 respiratory tube development GO:0030324 lung development GO:0030900 forebrain development GO:0030902 hindbrain development GO:0030903 notochord development GO:0031099 regeneration GO:0031100 animal organ regeneration GO:0035239 tube morphogenesis GO:0035270 endocrine system development GO:0045667 regulation of osteoblast differentiation GO:0045740 positive regulation of DNA replication GO:0045880 positive regulation of smoothened signaling pathway GO:0048232 male gamete generation GO:0048546 digestive tract morphogenesis GO:0048562 embryonic organ morphogenesis GO:0048565 digestive tract development GO:0048568 embryonic organ development GO:0048570 notochord morphogenesis GO:0048732 gland development GO:0050673 epithelial cell proliferation GO:0050678 regulation of epithelial cell proliferation GO:0051052 regulation of DNA metabolic process GO:0051054 positive regulation of DNA metabolic process GO:0051962 positive regulation of nervous system development GO:0055123 digestive system development GO:0060032 notochord regression GO:0060033 anatomical structure regression GO:0060070 canonical Wnt signaling pathway GO:0060541 respiratory system development GO:0060828 regulation of canonical Wnt signaling pathway GO:0061008 hepaticobiliary system development GO:0072574 hepatocyte proliferation GO:0072575 epithelial cell proliferation involved in liver morphogenesis GO:0072576 liver morphogenesis GO:0090090 negative regulation of canonical Wnt signaling pathway GO:0097421 liver regeneration GO:0198738 cell-cell signaling by wnt GO:2000027 regulation of organ morphogenesis GO:2000177 regulation of neural precursor cell proliferation GO:2000179 positive regulation of neural precursor cell proliferation GO:2000345 regulation of hepatocyte proliferation |
Molecular Function |
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000987 core promoter proximal region sequence-specific DNA binding GO:0001159 core promoter proximal region DNA binding GO:0003682 chromatin binding GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding GO:0008017 microtubule binding GO:0015631 tubulin binding |
Cellular Component |
GO:0005929 cilium GO:0005930 axoneme GO:0044441 ciliary part GO:0072372 primary cilium GO:0097014 ciliary plasm GO:0097542 ciliary tip GO:0097546 ciliary base |
KEGG |
hsa04024 cAMP signaling pathway hsa04340 Hedgehog signaling pathway |
Reactome |
R-HSA-5610780: Degradation of GLI1 by the proteasome R-HSA-5635851: GLI proteins bind promoters of Hh responsive genes to promote transcription R-HSA-5610787: Hedgehog 'off' state R-HSA-5632684: Hedgehog 'on' state R-HSA-162582: Signal Transduction R-HSA-5358351: Signaling by Hedgehog |
Summary | |
---|---|
Symbol | GLI1 |
Name | GLI family zinc finger 1 |
Aliases | GLI; glioma-associated oncogene homolog 1 (zinc finger protein); glioma-associated oncogene family zinc fing ...... |
Chromosomal Location | 12q13.2-q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between GLI1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | GLI1 |
Name | GLI family zinc finger 1 |
Aliases | GLI; glioma-associated oncogene homolog 1 (zinc finger protein); glioma-associated oncogene family zinc fing ...... |
Chromosomal Location | 12q13.2-q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of GLI1 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | GLI1 |
Name | GLI family zinc finger 1 |
Aliases | GLI; glioma-associated oncogene homolog 1 (zinc finger protein); glioma-associated oncogene family zinc fing ...... |
Chromosomal Location | 12q13.2-q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of GLI1 in various data sets.
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Points in the above scatter plot represent the mutation difference of GLI1 in various data sets.
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Summary | |
---|---|
Symbol | GLI1 |
Name | GLI family zinc finger 1 |
Aliases | GLI; glioma-associated oncogene homolog 1 (zinc finger protein); glioma-associated oncogene family zinc fing ...... |
Chromosomal Location | 12q13.2-q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GLI1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | GLI1 |
Name | GLI family zinc finger 1 |
Aliases | GLI; glioma-associated oncogene homolog 1 (zinc finger protein); glioma-associated oncogene family zinc fing ...... |
Chromosomal Location | 12q13.2-q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GLI1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GLI1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | GLI1 |
Name | GLI family zinc finger 1 |
Aliases | GLI; glioma-associated oncogene homolog 1 (zinc finger protein); glioma-associated oncogene family zinc fing ...... |
Chromosomal Location | 12q13.2-q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GLI1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | GLI1 |
Name | GLI family zinc finger 1 |
Aliases | GLI; glioma-associated oncogene homolog 1 (zinc finger protein); glioma-associated oncogene family zinc fing ...... |
Chromosomal Location | 12q13.2-q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of GLI1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | GLI1 |
Name | GLI family zinc finger 1 |
Aliases | GLI; glioma-associated oncogene homolog 1 (zinc finger protein); glioma-associated oncogene family zinc fing ...... |
Chromosomal Location | 12q13.2-q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between GLI1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | GLI1 |
Name | GLI family zinc finger 1 |
Aliases | GLI; glioma-associated oncogene homolog 1 (zinc finger protein); glioma-associated oncogene family zinc fing ...... |
Chromosomal Location | 12q13.2-q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting GLI1 collected from DrugBank database. |
There is no record. |