Summary | |
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Symbol | GLS2 |
Name | glutaminase 2 (liver, mitochondrial) |
Aliases | LGA; hLGA; breast cell glutaminase; glutaminase I; phosphate-activated glutaminase; phosphate-dependent glut ...... |
Chromosomal Location | 12q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Mitochondrion |
Domain |
PF12796 Ankyrin repeats (3 copies) PF04960 Glutaminase |
Function |
Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation. |
Biological Process |
GO:0006520 cellular amino acid metabolic process GO:0006536 glutamate metabolic process GO:0006537 glutamate biosynthetic process GO:0006541 glutamine metabolic process GO:0006543 glutamine catabolic process GO:0006626 protein targeting to mitochondrion GO:0006820 anion transport GO:0006835 dicarboxylic acid transport GO:0006839 mitochondrial transport GO:0008652 cellular amino acid biosynthetic process GO:0009063 cellular amino acid catabolic process GO:0009064 glutamine family amino acid metabolic process GO:0009065 glutamine family amino acid catabolic process GO:0009084 glutamine family amino acid biosynthetic process GO:0010821 regulation of mitochondrion organization GO:0010822 positive regulation of mitochondrion organization GO:0014047 glutamate secretion GO:0015711 organic anion transport GO:0016053 organic acid biosynthetic process GO:0016054 organic acid catabolic process GO:0032386 regulation of intracellular transport GO:0032388 positive regulation of intracellular transport GO:0033157 regulation of intracellular protein transport GO:0043648 dicarboxylic acid metabolic process GO:0043650 dicarboxylic acid biosynthetic process GO:0044282 small molecule catabolic process GO:0044283 small molecule biosynthetic process GO:0046394 carboxylic acid biosynthetic process GO:0046395 carboxylic acid catabolic process GO:0046942 carboxylic acid transport GO:0051222 positive regulation of protein transport GO:0070585 protein localization to mitochondrion GO:0072593 reactive oxygen species metabolic process GO:0072655 establishment of protein localization to mitochondrion GO:0090316 positive regulation of intracellular protein transport GO:1901565 organonitrogen compound catabolic process GO:1901605 alpha-amino acid metabolic process GO:1901606 alpha-amino acid catabolic process GO:1901607 alpha-amino acid biosynthetic process GO:1903214 regulation of protein targeting to mitochondrion GO:1903533 regulation of protein targeting GO:1903747 regulation of establishment of protein localization to mitochondrion GO:1903749 positive regulation of establishment of protein localization to mitochondrion GO:1903829 positive regulation of cellular protein localization GO:1903955 positive regulation of protein targeting to mitochondrion GO:1904951 positive regulation of establishment of protein localization |
Molecular Function |
GO:0004359 glutaminase activity GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
Cellular Component |
GO:0005759 mitochondrial matrix |
KEGG |
hsa04724 Glutamatergic synapse hsa04727 GABAergic synapse hsa04964 Proximal tubule bicarbonate reclamation hsa00250 Alanine, aspartate and glutamate metabolism hsa00471 D-Glutamine and D-glutamate metabolism hsa01100 Metabolic pathways |
Reactome |
R-HSA-70614: Amino acid synthesis and interconversion (transamination) R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-210500: Glutamate Neurotransmitter Release Cycle R-HSA-1430728: Metabolism R-HSA-71291: Metabolism of amino acids and derivatives R-HSA-112316: Neuronal System R-HSA-112310: Neurotransmitter Release Cycle R-HSA-5628897: TP53 Regulates Metabolic Genes R-HSA-3700989: Transcriptional Regulation by TP53 R-HSA-112315: Transmission across Chemical Synapses |
Summary | |
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Symbol | GLS2 |
Name | glutaminase 2 (liver, mitochondrial) |
Aliases | LGA; hLGA; breast cell glutaminase; glutaminase I; phosphate-activated glutaminase; phosphate-dependent glut ...... |
Chromosomal Location | 12q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between GLS2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | GLS2 |
Name | glutaminase 2 (liver, mitochondrial) |
Aliases | LGA; hLGA; breast cell glutaminase; glutaminase I; phosphate-activated glutaminase; phosphate-dependent glut ...... |
Chromosomal Location | 12q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of GLS2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | GLS2 |
Name | glutaminase 2 (liver, mitochondrial) |
Aliases | LGA; hLGA; breast cell glutaminase; glutaminase I; phosphate-activated glutaminase; phosphate-dependent glut ...... |
Chromosomal Location | 12q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of GLS2 in various data sets.
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Points in the above scatter plot represent the mutation difference of GLS2 in various data sets.
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Summary | |
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Symbol | GLS2 |
Name | glutaminase 2 (liver, mitochondrial) |
Aliases | LGA; hLGA; breast cell glutaminase; glutaminase I; phosphate-activated glutaminase; phosphate-dependent glut ...... |
Chromosomal Location | 12q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GLS2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | GLS2 |
Name | glutaminase 2 (liver, mitochondrial) |
Aliases | LGA; hLGA; breast cell glutaminase; glutaminase I; phosphate-activated glutaminase; phosphate-dependent glut ...... |
Chromosomal Location | 12q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GLS2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GLS2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | GLS2 |
Name | glutaminase 2 (liver, mitochondrial) |
Aliases | LGA; hLGA; breast cell glutaminase; glutaminase I; phosphate-activated glutaminase; phosphate-dependent glut ...... |
Chromosomal Location | 12q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GLS2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | GLS2 |
Name | glutaminase 2 (liver, mitochondrial) |
Aliases | LGA; hLGA; breast cell glutaminase; glutaminase I; phosphate-activated glutaminase; phosphate-dependent glut ...... |
Chromosomal Location | 12q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of GLS2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | GLS2 |
Name | glutaminase 2 (liver, mitochondrial) |
Aliases | LGA; hLGA; breast cell glutaminase; glutaminase I; phosphate-activated glutaminase; phosphate-dependent glut ...... |
Chromosomal Location | 12q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between GLS2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | GLS2 |
Name | glutaminase 2 (liver, mitochondrial) |
Aliases | LGA; hLGA; breast cell glutaminase; glutaminase I; phosphate-activated glutaminase; phosphate-dependent glut ...... |
Chromosomal Location | 12q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting GLS2 collected from DrugBank database. |
Details on drugs targeting GLS2.
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