Summary | |
---|---|
Symbol | GLYAT |
Name | glycine-N-acyltransferase |
Aliases | GAT; ACGNAT; AAc; HRP-1(CLP); acyl-CoA:glycine N-acyltransferase; aralkyl acyl-CoA N-acyltransferase; aralky ...... |
Chromosomal Location | 11q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Mitochondrion |
Domain |
PF08444 Aralkyl acyl-CoA PF06021 Aralkyl acyl-CoA |
Function |
Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate numerous substrates to form a variety of N-acylglycines, with a preference for benzoyl-CoA over phenylacetyl-CoA as acyl donors. Thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid. |
Biological Process |
GO:0006520 cellular amino acid metabolic process GO:0006544 glycine metabolic process GO:0006637 acyl-CoA metabolic process GO:0006732 coenzyme metabolic process GO:0006790 sulfur compound metabolic process GO:0006805 xenobiotic metabolic process GO:0009069 serine family amino acid metabolic process GO:0009410 response to xenobiotic stimulus GO:0009636 response to toxic substance GO:0035383 thioester metabolic process GO:0051186 cofactor metabolic process GO:0071466 cellular response to xenobiotic stimulus GO:1901605 alpha-amino acid metabolic process |
Molecular Function |
GO:0016410 N-acyltransferase activity GO:0016746 transferase activity, transferring acyl groups GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GO:0047961 glycine N-acyltransferase activity GO:0047962 glycine N-benzoyltransferase activity |
Cellular Component |
GO:0005759 mitochondrial matrix |
KEGG |
hsa00360 Phenylalanine metabolism |
Reactome |
R-HSA-156587: Amino Acid conjugation R-HSA-211859: Biological oxidations R-HSA-177135: Conjugation of benzoate with glycine R-HSA-159424: Conjugation of carboxylic acids R-HSA-177128: Conjugation of salicylate with glycine R-HSA-1430728: Metabolism R-HSA-156580: Phase II conjugation |
Summary | |
---|---|
Symbol | GLYAT |
Name | glycine-N-acyltransferase |
Aliases | GAT; ACGNAT; AAc; HRP-1(CLP); acyl-CoA:glycine N-acyltransferase; aralkyl acyl-CoA N-acyltransferase; aralky ...... |
Chromosomal Location | 11q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between GLYAT and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | GLYAT |
Name | glycine-N-acyltransferase |
Aliases | GAT; ACGNAT; AAc; HRP-1(CLP); acyl-CoA:glycine N-acyltransferase; aralkyl acyl-CoA N-acyltransferase; aralky ...... |
Chromosomal Location | 11q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of GLYAT in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | GLYAT |
Name | glycine-N-acyltransferase |
Aliases | GAT; ACGNAT; AAc; HRP-1(CLP); acyl-CoA:glycine N-acyltransferase; aralkyl acyl-CoA N-acyltransferase; aralky ...... |
Chromosomal Location | 11q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of GLYAT in various data sets.
|
Points in the above scatter plot represent the mutation difference of GLYAT in various data sets.
|
Summary | |
---|---|
Symbol | GLYAT |
Name | glycine-N-acyltransferase |
Aliases | GAT; ACGNAT; AAc; HRP-1(CLP); acyl-CoA:glycine N-acyltransferase; aralkyl acyl-CoA N-acyltransferase; aralky ...... |
Chromosomal Location | 11q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GLYAT. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | GLYAT |
Name | glycine-N-acyltransferase |
Aliases | GAT; ACGNAT; AAc; HRP-1(CLP); acyl-CoA:glycine N-acyltransferase; aralkyl acyl-CoA N-acyltransferase; aralky ...... |
Chromosomal Location | 11q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GLYAT. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GLYAT. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | GLYAT |
Name | glycine-N-acyltransferase |
Aliases | GAT; ACGNAT; AAc; HRP-1(CLP); acyl-CoA:glycine N-acyltransferase; aralkyl acyl-CoA N-acyltransferase; aralky ...... |
Chromosomal Location | 11q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GLYAT. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | GLYAT |
Name | glycine-N-acyltransferase |
Aliases | GAT; ACGNAT; AAc; HRP-1(CLP); acyl-CoA:glycine N-acyltransferase; aralkyl acyl-CoA N-acyltransferase; aralky ...... |
Chromosomal Location | 11q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of GLYAT expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | GLYAT |
Name | glycine-N-acyltransferase |
Aliases | GAT; ACGNAT; AAc; HRP-1(CLP); acyl-CoA:glycine N-acyltransferase; aralkyl acyl-CoA N-acyltransferase; aralky ...... |
Chromosomal Location | 11q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between GLYAT and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | GLYAT |
Name | glycine-N-acyltransferase |
Aliases | GAT; ACGNAT; AAc; HRP-1(CLP); acyl-CoA:glycine N-acyltransferase; aralkyl acyl-CoA N-acyltransferase; aralky ...... |
Chromosomal Location | 11q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting GLYAT collected from DrugBank database. |
Details on drugs targeting GLYAT.
|