Summary | |
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Symbol | GMDS |
Name | GDP-mannose 4,6-dehydratase |
Aliases | GMD; SDR3E1; short chain dehydrogenase/reductase family 3E, member 1; GDP-D-mannose dehydratase; GDP-mannose ...... |
Chromosomal Location | 6p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | - |
Domain |
PF16363 GDP-mannose 4 |
Function |
Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose. |
Biological Process |
GO:0007219 Notch signaling pathway GO:0009225 nucleotide-sugar metabolic process GO:0009226 nucleotide-sugar biosynthetic process GO:0019673 GDP-mannose metabolic process GO:0042350 GDP-L-fucose biosynthetic process GO:0042351 'de novo' GDP-L-fucose biosynthetic process GO:0046368 GDP-L-fucose metabolic process |
Molecular Function |
GO:0008446 GDP-mannose 4,6-dehydratase activity GO:0016829 lyase activity GO:0016835 carbon-oxygen lyase activity GO:0016836 hydro-lyase activity GO:0048037 cofactor binding GO:0050661 NADP binding GO:0050662 coenzyme binding GO:0070401 NADP+ binding |
Cellular Component | - |
KEGG |
hsa00051 Fructose and mannose metabolism hsa00520 Amino sugar and nucleotide sugar metabolism hsa01100 Metabolic pathways |
Reactome |
R-HSA-446203: Asparagine N-linked glycosylation R-HSA-446193: Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-6787639: GDP-fucose biosynthesis R-HSA-392499: Metabolism of proteins R-HSA-597592: Post-translational protein modification R-HSA-446219: Synthesis of substrates in N-glycan biosythesis |
Summary | |
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Symbol | GMDS |
Name | GDP-mannose 4,6-dehydratase |
Aliases | GMD; SDR3E1; short chain dehydrogenase/reductase family 3E, member 1; GDP-D-mannose dehydratase; GDP-mannose ...... |
Chromosomal Location | 6p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between GMDS and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between GMDS and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | GMDS |
Name | GDP-mannose 4,6-dehydratase |
Aliases | GMD; SDR3E1; short chain dehydrogenase/reductase family 3E, member 1; GDP-D-mannose dehydratase; GDP-mannose ...... |
Chromosomal Location | 6p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of GMDS in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | GMDS |
Name | GDP-mannose 4,6-dehydratase |
Aliases | GMD; SDR3E1; short chain dehydrogenase/reductase family 3E, member 1; GDP-D-mannose dehydratase; GDP-mannose ...... |
Chromosomal Location | 6p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of GMDS in various data sets.
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Points in the above scatter plot represent the mutation difference of GMDS in various data sets.
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Summary | |
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Symbol | GMDS |
Name | GDP-mannose 4,6-dehydratase |
Aliases | GMD; SDR3E1; short chain dehydrogenase/reductase family 3E, member 1; GDP-D-mannose dehydratase; GDP-mannose ...... |
Chromosomal Location | 6p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GMDS. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | GMDS |
Name | GDP-mannose 4,6-dehydratase |
Aliases | GMD; SDR3E1; short chain dehydrogenase/reductase family 3E, member 1; GDP-D-mannose dehydratase; GDP-mannose ...... |
Chromosomal Location | 6p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GMDS. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GMDS. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | GMDS |
Name | GDP-mannose 4,6-dehydratase |
Aliases | GMD; SDR3E1; short chain dehydrogenase/reductase family 3E, member 1; GDP-D-mannose dehydratase; GDP-mannose ...... |
Chromosomal Location | 6p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GMDS. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | GMDS |
Name | GDP-mannose 4,6-dehydratase |
Aliases | GMD; SDR3E1; short chain dehydrogenase/reductase family 3E, member 1; GDP-D-mannose dehydratase; GDP-mannose ...... |
Chromosomal Location | 6p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of GMDS expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | GMDS |
Name | GDP-mannose 4,6-dehydratase |
Aliases | GMD; SDR3E1; short chain dehydrogenase/reductase family 3E, member 1; GDP-D-mannose dehydratase; GDP-mannose ...... |
Chromosomal Location | 6p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between GMDS and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | GMDS |
Name | GDP-mannose 4,6-dehydratase |
Aliases | GMD; SDR3E1; short chain dehydrogenase/reductase family 3E, member 1; GDP-D-mannose dehydratase; GDP-mannose ...... |
Chromosomal Location | 6p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting GMDS collected from DrugBank database. |
Details on drugs targeting GMDS.
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