Summary | |
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Symbol | GML |
Name | glycosylphosphatidylinositol anchored molecule like |
Aliases | LY6DL; GPI anchored molecule like protein; glycosylphosphatidylinositol anchored molecule like protein; Glyc ...... |
Chromosomal Location | 8q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Lipid-anchor, GPI-anchor |
Domain | - |
Function |
May play a role in the apoptotic pathway or cell-cycle regulation induced by p53/TP53 after DNA damage. |
Biological Process |
GO:0000075 cell cycle checkpoint GO:0000077 DNA damage checkpoint GO:0000082 G1/S transition of mitotic cell cycle GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0007050 cell cycle arrest GO:0007093 mitotic cell cycle checkpoint GO:0007346 regulation of mitotic cell cycle GO:0010948 negative regulation of cell cycle process GO:0030330 DNA damage response, signal transduction by p53 class mediator GO:0031570 DNA integrity checkpoint GO:0031571 mitotic G1 DNA damage checkpoint GO:0042770 signal transduction in response to DNA damage GO:0044770 cell cycle phase transition GO:0044772 mitotic cell cycle phase transition GO:0044773 mitotic DNA damage checkpoint GO:0044774 mitotic DNA integrity checkpoint GO:0044783 G1 DNA damage checkpoint GO:0044819 mitotic G1/S transition checkpoint GO:0044843 cell cycle G1/S phase transition GO:0045786 negative regulation of cell cycle GO:0045787 positive regulation of cell cycle GO:0045930 negative regulation of mitotic cell cycle GO:0071156 regulation of cell cycle arrest GO:0071158 positive regulation of cell cycle arrest GO:0072331 signal transduction by p53 class mediator GO:0072395 signal transduction involved in cell cycle checkpoint GO:0072401 signal transduction involved in DNA integrity checkpoint GO:0072413 signal transduction involved in mitotic cell cycle checkpoint GO:0072422 signal transduction involved in DNA damage checkpoint GO:0072431 signal transduction involved in mitotic G1 DNA damage checkpoint GO:0090068 positive regulation of cell cycle process GO:1901987 regulation of cell cycle phase transition GO:1901988 negative regulation of cell cycle phase transition GO:1901990 regulation of mitotic cell cycle phase transition GO:1901991 negative regulation of mitotic cell cycle phase transition GO:1902400 intracellular signal transduction involved in G1 DNA damage checkpoint GO:1902402 signal transduction involved in mitotic DNA damage checkpoint GO:1902403 signal transduction involved in mitotic DNA integrity checkpoint GO:1902806 regulation of cell cycle G1/S phase transition GO:1902807 negative regulation of cell cycle G1/S phase transition GO:2000045 regulation of G1/S transition of mitotic cell cycle GO:2000134 negative regulation of G1/S transition of mitotic cell cycle |
Molecular Function | - |
Cellular Component |
GO:0019898 extrinsic component of membrane GO:0031225 anchored component of membrane |
KEGG | - |
Reactome |
R-HSA-3371568: Attenuation phase R-HSA-3371556: Cellular response to heat stress R-HSA-2262752: Cellular responses to stress R-HSA-3371511: HSF1 activation R-HSA-3371571: HSF1-dependent transactivation R-HSA-3371453: Regulation of HSF1-mediated heat shock response |
Summary | |
---|---|
Symbol | GML |
Name | glycosylphosphatidylinositol anchored molecule like |
Aliases | LY6DL; GPI anchored molecule like protein; glycosylphosphatidylinositol anchored molecule like protein; Glyc ...... |
Chromosomal Location | 8q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between GML and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | GML |
Name | glycosylphosphatidylinositol anchored molecule like |
Aliases | LY6DL; GPI anchored molecule like protein; glycosylphosphatidylinositol anchored molecule like protein; Glyc ...... |
Chromosomal Location | 8q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of GML in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | GML |
Name | glycosylphosphatidylinositol anchored molecule like |
Aliases | LY6DL; GPI anchored molecule like protein; glycosylphosphatidylinositol anchored molecule like protein; Glyc ...... |
Chromosomal Location | 8q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of GML in various data sets.
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Points in the above scatter plot represent the mutation difference of GML in various data sets.
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Summary | |
---|---|
Symbol | GML |
Name | glycosylphosphatidylinositol anchored molecule like |
Aliases | LY6DL; GPI anchored molecule like protein; glycosylphosphatidylinositol anchored molecule like protein; Glyc ...... |
Chromosomal Location | 8q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GML. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | GML |
Name | glycosylphosphatidylinositol anchored molecule like |
Aliases | LY6DL; GPI anchored molecule like protein; glycosylphosphatidylinositol anchored molecule like protein; Glyc ...... |
Chromosomal Location | 8q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GML. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GML. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | GML |
Name | glycosylphosphatidylinositol anchored molecule like |
Aliases | LY6DL; GPI anchored molecule like protein; glycosylphosphatidylinositol anchored molecule like protein; Glyc ...... |
Chromosomal Location | 8q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GML. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | GML |
Name | glycosylphosphatidylinositol anchored molecule like |
Aliases | LY6DL; GPI anchored molecule like protein; glycosylphosphatidylinositol anchored molecule like protein; Glyc ...... |
Chromosomal Location | 8q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of GML expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | GML |
Name | glycosylphosphatidylinositol anchored molecule like |
Aliases | LY6DL; GPI anchored molecule like protein; glycosylphosphatidylinositol anchored molecule like protein; Glyc ...... |
Chromosomal Location | 8q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between GML and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | GML |
Name | glycosylphosphatidylinositol anchored molecule like |
Aliases | LY6DL; GPI anchored molecule like protein; glycosylphosphatidylinositol anchored molecule like protein; Glyc ...... |
Chromosomal Location | 8q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting GML collected from DrugBank database. |
There is no record. |