Summary | |
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Symbol | GNA11 |
Name | guanine nucleotide binding protein (G protein), alpha 11 (Gq class) |
Aliases | FBH; FBH2; FHH2; HHC2; hypocalciuric hypercalcemia 2; GNA-11; HYPOC2; G-protein subunit alpha-11; g alpha-11 ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Lipid-anchor Cytoplasm Note=In testicular cells, expressed exclusively in the cytoplasm. |
Domain |
PF00503 G-protein alpha subunit |
Function |
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C. |
Biological Process |
GO:0001501 skeletal system development GO:0001508 action potential GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway GO:0007212 dopamine receptor signaling pathway GO:0007213 G-protein coupled acetylcholine receptor signaling pathway GO:0007507 heart development GO:0007596 blood coagulation GO:0007599 hemostasis GO:0007602 phototransduction GO:0007603 phototransduction, visible light GO:0007623 circadian rhythm GO:0009268 response to pH GO:0009314 response to radiation GO:0009416 response to light stimulus GO:0009581 detection of external stimulus GO:0009582 detection of abiotic stimulus GO:0009583 detection of light stimulus GO:0009584 detection of visible light GO:0009649 entrainment of circadian clock GO:0030168 platelet activation GO:0030318 melanocyte differentiation GO:0042391 regulation of membrane potential GO:0042752 regulation of circadian rhythm GO:0043473 pigmentation GO:0045634 regulation of melanocyte differentiation GO:0048066 developmental pigmentation GO:0048070 regulation of developmental pigmentation GO:0048511 rhythmic process GO:0050817 coagulation GO:0050878 regulation of body fluid levels GO:0050931 pigment cell differentiation GO:0050932 regulation of pigment cell differentiation GO:0060158 phospholipase C-activating dopamine receptor signaling pathway GO:0060359 response to ammonium ion GO:0071214 cellular response to abiotic stimulus GO:0071242 cellular response to ammonium ion GO:0071467 cellular response to pH GO:0095500 acetylcholine receptor signaling pathway GO:1903831 signal transduction involved in cellular response to ammonium ion GO:1905144 response to acetylcholine GO:1905145 cellular response to acetylcholine |
Molecular Function |
GO:0001664 G-protein coupled receptor binding GO:0003924 GTPase activity GO:0005525 GTP binding GO:0019001 guanyl nucleotide binding GO:0031683 G-protein beta/gamma-subunit complex binding GO:0031821 G-protein coupled serotonin receptor binding GO:0031826 type 2A serotonin receptor binding GO:0032561 guanyl ribonucleotide binding |
Cellular Component |
GO:0001750 photoreceptor outer segment GO:0005765 lysosomal membrane GO:0005929 cilium GO:0031513 nonmotile primary cilium GO:0072372 primary cilium GO:0098852 lytic vacuole membrane |
KEGG |
hsa04020 Calcium signaling pathway hsa04022 cGMP-PKG signaling pathway hsa04270 Vascular smooth muscle contraction hsa04540 Gap junction hsa04725 Cholinergic synapse hsa04730 Long-term depression hsa04911 Insulin secretion hsa04912 GnRH signaling pathway |
Reactome |
R-HSA-418592: ADP signalling through P2Y purinoceptor 1 R-HSA-399997: Acetylcholine regulates insulin secretion R-HSA-434316: Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-400451: Free fatty acids regulate insulin secretion R-HSA-416476: G alpha (q) signalling events R-HSA-388396: GPCR downstream signaling R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-109582: Hemostasis R-HSA-163685: Integration of energy metabolism R-HSA-1430728: Metabolism R-HSA-76002: Platelet activation, signaling and aggregation R-HSA-422356: Regulation of insulin secretion R-HSA-162582: Signal Transduction R-HSA-392518: Signal amplification R-HSA-372790: Signaling by GPCR R-HSA-456926: Thrombin signalling through proteinase activated receptors (PARs) R-HSA-428930: Thromboxane signalling through TP receptor |
Summary | |
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Symbol | GNA11 |
Name | guanine nucleotide binding protein (G protein), alpha 11 (Gq class) |
Aliases | FBH; FBH2; FHH2; HHC2; hypocalciuric hypercalcemia 2; GNA-11; HYPOC2; G-protein subunit alpha-11; g alpha-11 ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between GNA11 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | GNA11 |
Name | guanine nucleotide binding protein (G protein), alpha 11 (Gq class) |
Aliases | FBH; FBH2; FHH2; HHC2; hypocalciuric hypercalcemia 2; GNA-11; HYPOC2; G-protein subunit alpha-11; g alpha-11 ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of GNA11 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | GNA11 |
Name | guanine nucleotide binding protein (G protein), alpha 11 (Gq class) |
Aliases | FBH; FBH2; FHH2; HHC2; hypocalciuric hypercalcemia 2; GNA-11; HYPOC2; G-protein subunit alpha-11; g alpha-11 ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of GNA11 in various data sets.
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Points in the above scatter plot represent the mutation difference of GNA11 in various data sets.
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Summary | |
---|---|
Symbol | GNA11 |
Name | guanine nucleotide binding protein (G protein), alpha 11 (Gq class) |
Aliases | FBH; FBH2; FHH2; HHC2; hypocalciuric hypercalcemia 2; GNA-11; HYPOC2; G-protein subunit alpha-11; g alpha-11 ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GNA11. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | GNA11 |
Name | guanine nucleotide binding protein (G protein), alpha 11 (Gq class) |
Aliases | FBH; FBH2; FHH2; HHC2; hypocalciuric hypercalcemia 2; GNA-11; HYPOC2; G-protein subunit alpha-11; g alpha-11 ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GNA11. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GNA11. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | GNA11 |
Name | guanine nucleotide binding protein (G protein), alpha 11 (Gq class) |
Aliases | FBH; FBH2; FHH2; HHC2; hypocalciuric hypercalcemia 2; GNA-11; HYPOC2; G-protein subunit alpha-11; g alpha-11 ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GNA11. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | GNA11 |
Name | guanine nucleotide binding protein (G protein), alpha 11 (Gq class) |
Aliases | FBH; FBH2; FHH2; HHC2; hypocalciuric hypercalcemia 2; GNA-11; HYPOC2; G-protein subunit alpha-11; g alpha-11 ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of GNA11 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | GNA11 |
Name | guanine nucleotide binding protein (G protein), alpha 11 (Gq class) |
Aliases | FBH; FBH2; FHH2; HHC2; hypocalciuric hypercalcemia 2; GNA-11; HYPOC2; G-protein subunit alpha-11; g alpha-11 ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between GNA11 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | GNA11 |
Name | guanine nucleotide binding protein (G protein), alpha 11 (Gq class) |
Aliases | FBH; FBH2; FHH2; HHC2; hypocalciuric hypercalcemia 2; GNA-11; HYPOC2; G-protein subunit alpha-11; g alpha-11 ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting GNA11 collected from DrugBank database. |
There is no record. |