Summary | |
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Symbol | GNE |
Name | glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase |
Aliases | Uae1; IBM2; UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase; DMRV; GLCNE; N-acylmannosamine k ...... |
Chromosomal Location | 9p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm |
Domain |
PF02350 UDP-N-acetylglucosamine 2-epimerase PF00480 ROK family |
Function |
Regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. Plays an essential role in early development (By similarity). Required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells. |
Biological Process |
GO:0006040 amino sugar metabolic process GO:0006044 N-acetylglucosamine metabolic process GO:0006045 N-acetylglucosamine biosynthetic process GO:0006047 UDP-N-acetylglucosamine metabolic process GO:0006054 N-acetylneuraminate metabolic process GO:0009225 nucleotide-sugar metabolic process GO:0044262 cellular carbohydrate metabolic process GO:0046349 amino sugar biosynthetic process GO:0046835 carbohydrate phosphorylation GO:1901071 glucosamine-containing compound metabolic process GO:1901073 glucosamine-containing compound biosynthetic process |
Molecular Function |
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GO:0008761 UDP-N-acetylglucosamine 2-epimerase activity GO:0009384 N-acylmannosamine kinase activity GO:0016798 hydrolase activity, acting on glycosyl bonds GO:0016853 isomerase activity GO:0016854 racemase and epimerase activity GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GO:0019200 carbohydrate kinase activity |
Cellular Component | - |
KEGG |
hsa00520 Amino sugar and nucleotide sugar metabolism hsa01100 Metabolic pathways |
Reactome |
R-HSA-446203: Asparagine N-linked glycosylation R-HSA-446193: Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-392499: Metabolism of proteins R-HSA-597592: Post-translational protein modification R-HSA-4085001: Sialic acid metabolism R-HSA-446219: Synthesis of substrates in N-glycan biosythesis |
Summary | |
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Symbol | GNE |
Name | glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase |
Aliases | Uae1; IBM2; UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase; DMRV; GLCNE; N-acylmannosamine k ...... |
Chromosomal Location | 9p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between GNE and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | GNE |
Name | glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase |
Aliases | Uae1; IBM2; UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase; DMRV; GLCNE; N-acylmannosamine k ...... |
Chromosomal Location | 9p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of GNE in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | GNE |
Name | glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase |
Aliases | Uae1; IBM2; UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase; DMRV; GLCNE; N-acylmannosamine k ...... |
Chromosomal Location | 9p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of GNE in various data sets.
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Points in the above scatter plot represent the mutation difference of GNE in various data sets.
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Summary | |
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Symbol | GNE |
Name | glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase |
Aliases | Uae1; IBM2; UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase; DMRV; GLCNE; N-acylmannosamine k ...... |
Chromosomal Location | 9p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GNE. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | GNE |
Name | glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase |
Aliases | Uae1; IBM2; UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase; DMRV; GLCNE; N-acylmannosamine k ...... |
Chromosomal Location | 9p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GNE. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GNE. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | GNE |
Name | glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase |
Aliases | Uae1; IBM2; UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase; DMRV; GLCNE; N-acylmannosamine k ...... |
Chromosomal Location | 9p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GNE. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | GNE |
Name | glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase |
Aliases | Uae1; IBM2; UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase; DMRV; GLCNE; N-acylmannosamine k ...... |
Chromosomal Location | 9p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of GNE expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | GNE |
Name | glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase |
Aliases | Uae1; IBM2; UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase; DMRV; GLCNE; N-acylmannosamine k ...... |
Chromosomal Location | 9p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between GNE and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | GNE |
Name | glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase |
Aliases | Uae1; IBM2; UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase; DMRV; GLCNE; N-acylmannosamine k ...... |
Chromosomal Location | 9p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting GNE collected from DrugBank database. |
There is no record. |