Browse GNL2

Summary
SymbolGNL2
Nameguanine nucleotide binding protein-like 2 (nucleolar)
Aliases Ngp-1; HUMAUANTIG; Nog2; Nug2; nucleostemin-2; NGP1; autoantigen NGP-1; novel nucleolar guanosine 5'-triphos ......
Chromosomal Location1p34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus, nucleolus
Domain PF01926 50S ribosome-binding GTPase
PF08153 NGP1NT (NUC091) domain
Function

GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation (By similarity). May promote cell proliferation possibly by increasing p53/TP53 protein levels, and consequently those of its downstream product CDKN1A/p21, and decreasing RPL23A protein levels (PubMed:26203195).

> Gene Ontology
 
Biological Process GO:0022613 ribonucleoprotein complex biogenesis
GO:0042254 ribosome biogenesis
Molecular Function GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0019001 guanyl nucleotide binding
GO:0032561 guanyl ribonucleotide binding
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa03008 Ribosome biogenesis in eukaryotes
Reactome -
Summary
SymbolGNL2
Nameguanine nucleotide binding protein-like 2 (nucleolar)
Aliases Ngp-1; HUMAUANTIG; Nog2; Nug2; nucleostemin-2; NGP1; autoantigen NGP-1; novel nucleolar guanosine 5'-triphos ......
Chromosomal Location1p34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between GNL2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolGNL2
Nameguanine nucleotide binding protein-like 2 (nucleolar)
Aliases Ngp-1; HUMAUANTIG; Nog2; Nug2; nucleostemin-2; NGP1; autoantigen NGP-1; novel nucleolar guanosine 5'-triphos ......
Chromosomal Location1p34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of GNL2 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.56 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolGNL2
Nameguanine nucleotide binding protein-like 2 (nucleolar)
Aliases Ngp-1; HUMAUANTIG; Nog2; Nug2; nucleostemin-2; NGP1; autoantigen NGP-1; novel nucleolar guanosine 5'-triphos ......
Chromosomal Location1p34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of GNL2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.1310.435
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.0110.996
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.2150.893
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.1130.661
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.010.996
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.2440.923
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.0540.889
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.2010.907
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.3540.851
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.1630.913
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.6710.766
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.1240.051
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of GNL2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277302.7-2.71
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275903.4-3.41
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolGNL2
Nameguanine nucleotide binding protein-like 2 (nucleolar)
Aliases Ngp-1; HUMAUANTIG; Nog2; Nug2; nucleostemin-2; NGP1; autoantigen NGP-1; novel nucleolar guanosine 5'-triphos ......
Chromosomal Location1p34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GNL2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolGNL2
Nameguanine nucleotide binding protein-like 2 (nucleolar)
Aliases Ngp-1; HUMAUANTIG; Nog2; Nug2; nucleostemin-2; NGP1; autoantigen NGP-1; novel nucleolar guanosine 5'-triphos ......
Chromosomal Location1p34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GNL2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GNL2.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolGNL2
Nameguanine nucleotide binding protein-like 2 (nucleolar)
Aliases Ngp-1; HUMAUANTIG; Nog2; Nug2; nucleostemin-2; NGP1; autoantigen NGP-1; novel nucleolar guanosine 5'-triphos ......
Chromosomal Location1p34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GNL2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolGNL2
Nameguanine nucleotide binding protein-like 2 (nucleolar)
Aliases Ngp-1; HUMAUANTIG; Nog2; Nug2; nucleostemin-2; NGP1; autoantigen NGP-1; novel nucleolar guanosine 5'-triphos ......
Chromosomal Location1p34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of GNL2 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolGNL2
Nameguanine nucleotide binding protein-like 2 (nucleolar)
Aliases Ngp-1; HUMAUANTIG; Nog2; Nug2; nucleostemin-2; NGP1; autoantigen NGP-1; novel nucleolar guanosine 5'-triphos ......
Chromosomal Location1p34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between GNL2 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolGNL2
Nameguanine nucleotide binding protein-like 2 (nucleolar)
Aliases Ngp-1; HUMAUANTIG; Nog2; Nug2; nucleostemin-2; NGP1; autoantigen NGP-1; novel nucleolar guanosine 5'-triphos ......
Chromosomal Location1p34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting GNL2 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.