Summary | |
---|---|
Symbol | GNL2 |
Name | guanine nucleotide binding protein-like 2 (nucleolar) |
Aliases | Ngp-1; HUMAUANTIG; Nog2; Nug2; nucleostemin-2; NGP1; autoantigen NGP-1; novel nucleolar guanosine 5'-triphos ...... |
Chromosomal Location | 1p34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus, nucleolus |
Domain |
PF01926 50S ribosome-binding GTPase PF08153 NGP1NT (NUC091) domain |
Function |
GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation (By similarity). May promote cell proliferation possibly by increasing p53/TP53 protein levels, and consequently those of its downstream product CDKN1A/p21, and decreasing RPL23A protein levels (PubMed:26203195). |
Biological Process |
GO:0022613 ribonucleoprotein complex biogenesis GO:0042254 ribosome biogenesis |
Molecular Function |
GO:0003924 GTPase activity GO:0005525 GTP binding GO:0019001 guanyl nucleotide binding GO:0032561 guanyl ribonucleotide binding |
Cellular Component | - |
KEGG |
hsa03008 Ribosome biogenesis in eukaryotes |
Reactome | - |
Summary | |
---|---|
Symbol | GNL2 |
Name | guanine nucleotide binding protein-like 2 (nucleolar) |
Aliases | Ngp-1; HUMAUANTIG; Nog2; Nug2; nucleostemin-2; NGP1; autoantigen NGP-1; novel nucleolar guanosine 5'-triphos ...... |
Chromosomal Location | 1p34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between GNL2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | GNL2 |
Name | guanine nucleotide binding protein-like 2 (nucleolar) |
Aliases | Ngp-1; HUMAUANTIG; Nog2; Nug2; nucleostemin-2; NGP1; autoantigen NGP-1; novel nucleolar guanosine 5'-triphos ...... |
Chromosomal Location | 1p34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of GNL2 in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | GNL2 |
Name | guanine nucleotide binding protein-like 2 (nucleolar) |
Aliases | Ngp-1; HUMAUANTIG; Nog2; Nug2; nucleostemin-2; NGP1; autoantigen NGP-1; novel nucleolar guanosine 5'-triphos ...... |
Chromosomal Location | 1p34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of GNL2 in various data sets.
|
Points in the above scatter plot represent the mutation difference of GNL2 in various data sets.
|
Summary | |
---|---|
Symbol | GNL2 |
Name | guanine nucleotide binding protein-like 2 (nucleolar) |
Aliases | Ngp-1; HUMAUANTIG; Nog2; Nug2; nucleostemin-2; NGP1; autoantigen NGP-1; novel nucleolar guanosine 5'-triphos ...... |
Chromosomal Location | 1p34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GNL2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | GNL2 |
Name | guanine nucleotide binding protein-like 2 (nucleolar) |
Aliases | Ngp-1; HUMAUANTIG; Nog2; Nug2; nucleostemin-2; NGP1; autoantigen NGP-1; novel nucleolar guanosine 5'-triphos ...... |
Chromosomal Location | 1p34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GNL2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GNL2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | GNL2 |
Name | guanine nucleotide binding protein-like 2 (nucleolar) |
Aliases | Ngp-1; HUMAUANTIG; Nog2; Nug2; nucleostemin-2; NGP1; autoantigen NGP-1; novel nucleolar guanosine 5'-triphos ...... |
Chromosomal Location | 1p34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GNL2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | GNL2 |
Name | guanine nucleotide binding protein-like 2 (nucleolar) |
Aliases | Ngp-1; HUMAUANTIG; Nog2; Nug2; nucleostemin-2; NGP1; autoantigen NGP-1; novel nucleolar guanosine 5'-triphos ...... |
Chromosomal Location | 1p34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of GNL2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | GNL2 |
Name | guanine nucleotide binding protein-like 2 (nucleolar) |
Aliases | Ngp-1; HUMAUANTIG; Nog2; Nug2; nucleostemin-2; NGP1; autoantigen NGP-1; novel nucleolar guanosine 5'-triphos ...... |
Chromosomal Location | 1p34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between GNL2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | GNL2 |
Name | guanine nucleotide binding protein-like 2 (nucleolar) |
Aliases | Ngp-1; HUMAUANTIG; Nog2; Nug2; nucleostemin-2; NGP1; autoantigen NGP-1; novel nucleolar guanosine 5'-triphos ...... |
Chromosomal Location | 1p34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting GNL2 collected from DrugBank database. |
There is no record. |