Summary | |
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Symbol | GOSR1 |
Name | golgi SNAP receptor complex member 1 |
Aliases | GOS28; GS28; GOS-28; GOLIM2; golgi integral membrane protein 2; GOS28/P28; 28 kDa Golgi SNARE protein; 28 kD ...... |
Chromosomal Location | 17q11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Golgi apparatus membrane Single-pass type IV membrane protein Note=Localizes throughout the Golgi apparatus, with lowest levels in the trans-Golgi network (By similarity). Enriched on vesicular components at the terminal rims of the Golgi. Found in Golgi microtubules at low temperature (15 degrees Celsius). |
Domain | - |
Function |
Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi. |
Biological Process |
GO:0006888 ER to Golgi vesicle-mediated transport GO:0006891 intra-Golgi vesicle-mediated transport GO:0006903 vesicle targeting GO:0006906 vesicle fusion GO:0007034 vacuolar transport GO:0016050 vesicle organization GO:0016197 endosomal transport GO:0016482 cytosolic transport GO:0042147 retrograde transport, endosome to Golgi GO:0044801 single-organism membrane fusion GO:0048193 Golgi vesicle transport GO:0048199 vesicle targeting, to, from or within Golgi GO:0048209 regulation of vesicle targeting, to, from or within Golgi GO:0048284 organelle fusion GO:0051640 organelle localization GO:0051648 vesicle localization GO:0051650 establishment of vesicle localization GO:0051656 establishment of organelle localization GO:0060627 regulation of vesicle-mediated transport GO:0061025 membrane fusion GO:0090174 organelle membrane fusion |
Molecular Function |
GO:0000149 SNARE binding GO:0005484 SNAP receptor activity |
Cellular Component |
GO:0005795 Golgi stack GO:0005797 Golgi medial cisterna GO:0005801 cis-Golgi network GO:0030133 transport vesicle GO:0031201 SNARE complex GO:0031984 organelle subcompartment GO:0031985 Golgi cisterna GO:0098791 Golgi subcompartment |
KEGG |
hsa04130 SNARE interactions in vesicular transport |
Reactome |
R-HSA-446203: Asparagine N-linked glycosylation R-HSA-6807878: COPI-mediated anterograde transport R-HSA-199977: ER to Golgi Anterograde Transport R-HSA-6811442: Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811438: Intra-Golgi traffic R-HSA-199991: Membrane Trafficking R-HSA-392499: Metabolism of proteins R-HSA-597592: Post-translational protein modification R-HSA-948021: Transport to the Golgi and subsequent modification R-HSA-5653656: Vesicle-mediated transport |
Summary | |
---|---|
Symbol | GOSR1 |
Name | golgi SNAP receptor complex member 1 |
Aliases | GOS28; GS28; GOS-28; GOLIM2; golgi integral membrane protein 2; GOS28/P28; 28 kDa Golgi SNARE protein; 28 kD ...... |
Chromosomal Location | 17q11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between GOSR1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | GOSR1 |
Name | golgi SNAP receptor complex member 1 |
Aliases | GOS28; GS28; GOS-28; GOLIM2; golgi integral membrane protein 2; GOS28/P28; 28 kDa Golgi SNARE protein; 28 kD ...... |
Chromosomal Location | 17q11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of GOSR1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | GOSR1 |
Name | golgi SNAP receptor complex member 1 |
Aliases | GOS28; GS28; GOS-28; GOLIM2; golgi integral membrane protein 2; GOS28/P28; 28 kDa Golgi SNARE protein; 28 kD ...... |
Chromosomal Location | 17q11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of GOSR1 in various data sets.
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Points in the above scatter plot represent the mutation difference of GOSR1 in various data sets.
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Summary | |
---|---|
Symbol | GOSR1 |
Name | golgi SNAP receptor complex member 1 |
Aliases | GOS28; GS28; GOS-28; GOLIM2; golgi integral membrane protein 2; GOS28/P28; 28 kDa Golgi SNARE protein; 28 kD ...... |
Chromosomal Location | 17q11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GOSR1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | GOSR1 |
Name | golgi SNAP receptor complex member 1 |
Aliases | GOS28; GS28; GOS-28; GOLIM2; golgi integral membrane protein 2; GOS28/P28; 28 kDa Golgi SNARE protein; 28 kD ...... |
Chromosomal Location | 17q11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GOSR1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GOSR1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | GOSR1 |
Name | golgi SNAP receptor complex member 1 |
Aliases | GOS28; GS28; GOS-28; GOLIM2; golgi integral membrane protein 2; GOS28/P28; 28 kDa Golgi SNARE protein; 28 kD ...... |
Chromosomal Location | 17q11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GOSR1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | GOSR1 |
Name | golgi SNAP receptor complex member 1 |
Aliases | GOS28; GS28; GOS-28; GOLIM2; golgi integral membrane protein 2; GOS28/P28; 28 kDa Golgi SNARE protein; 28 kD ...... |
Chromosomal Location | 17q11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of GOSR1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | GOSR1 |
Name | golgi SNAP receptor complex member 1 |
Aliases | GOS28; GS28; GOS-28; GOLIM2; golgi integral membrane protein 2; GOS28/P28; 28 kDa Golgi SNARE protein; 28 kD ...... |
Chromosomal Location | 17q11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between GOSR1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | GOSR1 |
Name | golgi SNAP receptor complex member 1 |
Aliases | GOS28; GS28; GOS-28; GOLIM2; golgi integral membrane protein 2; GOS28/P28; 28 kDa Golgi SNARE protein; 28 kD ...... |
Chromosomal Location | 17q11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting GOSR1 collected from DrugBank database. |
There is no record. |