Summary | |
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Symbol | GOSR2 |
Name | golgi SNAP receptor complex member 2 |
Aliases | GS27; EPM6; 27 kDa Golgi SNARE protein; membrin |
Chromosomal Location | 17q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Golgi apparatus, cis-Golgi network membrane Single-pass type IV membrane protein Golgi apparatus membrane Endoplasmic reticulum membrane Note=Concentrated most in the intermediate compartment/cis-Golgi network and the cis-Golgi cisternae 1 and 2. Greatly reduced in concentration at the trans end of the Golgi apparatus. |
Domain | - |
Function |
Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network. |
Biological Process |
GO:0006623 protein targeting to vacuole GO:0006888 ER to Golgi vesicle-mediated transport GO:0006891 intra-Golgi vesicle-mediated transport GO:0006892 post-Golgi vesicle-mediated transport GO:0006896 Golgi to vacuole transport GO:0006900 membrane budding GO:0006901 vesicle coating GO:0006903 vesicle targeting GO:0006906 vesicle fusion GO:0006986 response to unfolded protein GO:0007034 vacuolar transport GO:0016050 vesicle organization GO:0016197 endosomal transport GO:0016482 cytosolic transport GO:0030968 endoplasmic reticulum unfolded protein response GO:0034620 cellular response to unfolded protein GO:0034976 response to endoplasmic reticulum stress GO:0035966 response to topologically incorrect protein GO:0035967 cellular response to topologically incorrect protein GO:0036498 IRE1-mediated unfolded protein response GO:0042147 retrograde transport, endosome to Golgi GO:0044801 single-organism membrane fusion GO:0048193 Golgi vesicle transport GO:0048199 vesicle targeting, to, from or within Golgi GO:0048207 vesicle targeting, rough ER to cis-Golgi GO:0048208 COPII vesicle coating GO:0048280 vesicle fusion with Golgi apparatus GO:0048284 organelle fusion GO:0051640 organelle localization GO:0051648 vesicle localization GO:0051650 establishment of vesicle localization GO:0051656 establishment of organelle localization GO:0061025 membrane fusion GO:0072665 protein localization to vacuole GO:0072666 establishment of protein localization to vacuole GO:0090114 COPII-coated vesicle budding GO:0090174 organelle membrane fusion |
Molecular Function |
GO:0000149 SNARE binding GO:0005484 SNAP receptor activity |
Cellular Component |
GO:0005770 late endosome GO:0005793 endoplasmic reticulum-Golgi intermediate compartment GO:0010008 endosome membrane GO:0012507 ER to Golgi transport vesicle membrane GO:0030133 transport vesicle GO:0030134 ER to Golgi transport vesicle GO:0030135 coated vesicle GO:0030658 transport vesicle membrane GO:0030659 cytoplasmic vesicle membrane GO:0030662 coated vesicle membrane GO:0031201 SNARE complex GO:0031902 late endosome membrane GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane GO:0044440 endosomal part |
KEGG |
hsa04130 SNARE interactions in vesicular transport |
Reactome |
R-HSA-446203: Asparagine N-linked glycosylation R-HSA-6807878: COPI-mediated anterograde transport R-HSA-204005: COPII (Coat Protein 2) Mediated Vesicle Transport R-HSA-5694530: Cargo concentration in the ER R-HSA-199977: ER to Golgi Anterograde Transport R-HSA-381070: IRE1alpha activates chaperones R-HSA-6811442: Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811438: Intra-Golgi traffic R-HSA-199991: Membrane Trafficking R-HSA-392499: Metabolism of proteins R-HSA-597592: Post-translational protein modification R-HSA-948021: Transport to the Golgi and subsequent modification R-HSA-381119: Unfolded Protein Response (UPR) R-HSA-5653656: Vesicle-mediated transport R-HSA-381038: XBP1(S) activates chaperone genes |
Summary | |
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Symbol | GOSR2 |
Name | golgi SNAP receptor complex member 2 |
Aliases | GS27; EPM6; 27 kDa Golgi SNARE protein; membrin |
Chromosomal Location | 17q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between GOSR2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | GOSR2 |
Name | golgi SNAP receptor complex member 2 |
Aliases | GS27; EPM6; 27 kDa Golgi SNARE protein; membrin |
Chromosomal Location | 17q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of GOSR2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | GOSR2 |
Name | golgi SNAP receptor complex member 2 |
Aliases | GS27; EPM6; 27 kDa Golgi SNARE protein; membrin |
Chromosomal Location | 17q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of GOSR2 in various data sets.
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Points in the above scatter plot represent the mutation difference of GOSR2 in various data sets.
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Summary | |
---|---|
Symbol | GOSR2 |
Name | golgi SNAP receptor complex member 2 |
Aliases | GS27; EPM6; 27 kDa Golgi SNARE protein; membrin |
Chromosomal Location | 17q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GOSR2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | GOSR2 |
Name | golgi SNAP receptor complex member 2 |
Aliases | GS27; EPM6; 27 kDa Golgi SNARE protein; membrin |
Chromosomal Location | 17q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GOSR2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GOSR2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | GOSR2 |
Name | golgi SNAP receptor complex member 2 |
Aliases | GS27; EPM6; 27 kDa Golgi SNARE protein; membrin |
Chromosomal Location | 17q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GOSR2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | GOSR2 |
Name | golgi SNAP receptor complex member 2 |
Aliases | GS27; EPM6; 27 kDa Golgi SNARE protein; membrin |
Chromosomal Location | 17q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of GOSR2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | GOSR2 |
Name | golgi SNAP receptor complex member 2 |
Aliases | GS27; EPM6; 27 kDa Golgi SNARE protein; membrin |
Chromosomal Location | 17q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between GOSR2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |