Browse GP1BA

Summary
SymbolGP1BA
Nameglycoprotein Ib (platelet), alpha polypeptide
Aliases CD42b; GP1B; BDPLT3; BSS; CD42b-alpha; DBPLT3; GPIbA; VWDP; GP-Ib alpha; antigen CD42b-alpha; platelet membr ......
Chromosomal Location17p13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Membrane; Single-pass type I membrane protein.
Domain PF13855 Leucine rich repeat
PF01462 Leucine rich repeat N-terminal domain
Function

GP-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to the A1 domain of vWF, which is already bound to the subendothelium.

> Gene Ontology
 
Biological Process GO:0001933 negative regulation of protein phosphorylation
GO:0006469 negative regulation of protein kinase activity
GO:0007259 JAK-STAT cascade
GO:0007596 blood coagulation
GO:0007597 blood coagulation, intrinsic pathway
GO:0007599 hemostasis
GO:0030168 platelet activation
GO:0030193 regulation of blood coagulation
GO:0030195 negative regulation of blood coagulation
GO:0032102 negative regulation of response to external stimulus
GO:0033673 negative regulation of kinase activity
GO:0034109 homotypic cell-cell adhesion
GO:0042326 negative regulation of phosphorylation
GO:0042730 fibrinolysis
GO:0046425 regulation of JAK-STAT cascade
GO:0046426 negative regulation of JAK-STAT cascade
GO:0050817 coagulation
GO:0050818 regulation of coagulation
GO:0050819 negative regulation of coagulation
GO:0050878 regulation of body fluid levels
GO:0051348 negative regulation of transferase activity
GO:0061041 regulation of wound healing
GO:0061045 negative regulation of wound healing
GO:0070493 thrombin receptor signaling pathway
GO:0070527 platelet aggregation
GO:0072376 protein activation cascade
GO:0072378 blood coagulation, fibrin clot formation
GO:0097696 STAT cascade
GO:1900046 regulation of hemostasis
GO:1900047 negative regulation of hemostasis
GO:1902532 negative regulation of intracellular signal transduction
GO:1903034 regulation of response to wounding
GO:1903035 negative regulation of response to wounding
GO:1904892 regulation of STAT cascade
GO:1904893 negative regulation of STAT cascade
Molecular Function GO:0001653 peptide receptor activity
GO:0004857 enzyme inhibitor activity
GO:0004860 protein kinase inhibitor activity
GO:0008528 G-protein coupled peptide receptor activity
GO:0015057 thrombin receptor activity
GO:0019207 kinase regulator activity
GO:0019210 kinase inhibitor activity
GO:0019887 protein kinase regulator activity
Cellular Component GO:0009897 external side of plasma membrane
GO:0031225 anchored component of membrane
GO:0031233 intrinsic component of external side of plasma membrane
GO:0031362 anchored component of external side of plasma membrane
GO:0046658 anchored component of plasma membrane
GO:0098552 side of membrane
> KEGG and Reactome Pathway
 
KEGG hsa04512 ECM-receptor interaction
hsa04611 Platelet activation
hsa04640 Hematopoietic cell lineage
Reactome R-HSA-140877: Formation of Fibrin Clot (Clotting Cascade)
R-HSA-430116: GP1b-IX-V activation signalling
R-HSA-109582: Hemostasis
R-HSA-140837: Intrinsic Pathway of Fibrin Clot Formation
R-HSA-75892: Platelet Adhesion to exposed collagen
R-HSA-76009: Platelet Aggregation (Plug Formation)
R-HSA-76002: Platelet activation, signaling and aggregation
Summary
SymbolGP1BA
Nameglycoprotein Ib (platelet), alpha polypeptide
Aliases CD42b; GP1B; BDPLT3; BSS; CD42b-alpha; DBPLT3; GPIbA; VWDP; GP-Ib alpha; antigen CD42b-alpha; platelet membr ......
Chromosomal Location17p13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between GP1BA and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolGP1BA
Nameglycoprotein Ib (platelet), alpha polypeptide
Aliases CD42b; GP1B; BDPLT3; BSS; CD42b-alpha; DBPLT3; GPIbA; VWDP; GP-Ib alpha; antigen CD42b-alpha; platelet membr ......
Chromosomal Location17p13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of GP1BA in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolGP1BA
Nameglycoprotein Ib (platelet), alpha polypeptide
Aliases CD42b; GP1B; BDPLT3; BSS; CD42b-alpha; DBPLT3; GPIbA; VWDP; GP-Ib alpha; antigen CD42b-alpha; platelet membr ......
Chromosomal Location17p13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of GP1BA in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.3790.339
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.7590.253
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.0930.867
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.4830.227
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.4130.816
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.5820.816
729033130MelanomaallAnti-PD-1 (nivolumab) 26231.3750.00747
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15111.8380.0165
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.980.235
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.1580.721
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.1480.807
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.1660.634
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of GP1BA in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141714.3014.30.196
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 414250250.222
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.703.70.27
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.703.70.314
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47014.3-14.31
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 111307.7-7.71
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 51208.3-8.31
Summary
SymbolGP1BA
Nameglycoprotein Ib (platelet), alpha polypeptide
Aliases CD42b; GP1B; BDPLT3; BSS; CD42b-alpha; DBPLT3; GPIbA; VWDP; GP-Ib alpha; antigen CD42b-alpha; platelet membr ......
Chromosomal Location17p13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GP1BA. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolGP1BA
Nameglycoprotein Ib (platelet), alpha polypeptide
Aliases CD42b; GP1B; BDPLT3; BSS; CD42b-alpha; DBPLT3; GPIbA; VWDP; GP-Ib alpha; antigen CD42b-alpha; platelet membr ......
Chromosomal Location17p13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GP1BA. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GP1BA.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolGP1BA
Nameglycoprotein Ib (platelet), alpha polypeptide
Aliases CD42b; GP1B; BDPLT3; BSS; CD42b-alpha; DBPLT3; GPIbA; VWDP; GP-Ib alpha; antigen CD42b-alpha; platelet membr ......
Chromosomal Location17p13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GP1BA. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolGP1BA
Nameglycoprotein Ib (platelet), alpha polypeptide
Aliases CD42b; GP1B; BDPLT3; BSS; CD42b-alpha; DBPLT3; GPIbA; VWDP; GP-Ib alpha; antigen CD42b-alpha; platelet membr ......
Chromosomal Location17p13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of GP1BA expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolGP1BA
Nameglycoprotein Ib (platelet), alpha polypeptide
Aliases CD42b; GP1B; BDPLT3; BSS; CD42b-alpha; DBPLT3; GPIbA; VWDP; GP-Ib alpha; antigen CD42b-alpha; platelet membr ......
Chromosomal Location17p13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between GP1BA and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolGP1BA
Nameglycoprotein Ib (platelet), alpha polypeptide
Aliases CD42b; GP1B; BDPLT3; BSS; CD42b-alpha; DBPLT3; GPIbA; VWDP; GP-Ib alpha; antigen CD42b-alpha; platelet membr ......
Chromosomal Location17p13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting GP1BA collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting GP1BA.
ID Name Drug Type Targets #Targets
DB05202Egaptivon pegolBiotechGP1BA, VWF2
DB05391liposomal prostaglandin E1Small MoleculeGP1BA1