Summary | |
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Symbol | GP9 |
Name | glycoprotein IX (platelet) |
Aliases | CD42a; GPIX; glycoprotein 9; CD antigen CD42a; GP-IX; Platelet glycoprotein IX |
Chromosomal Location | 3q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane; Single-pass type I membrane protein. |
Domain |
PF13855 Leucine rich repeat PF01462 Leucine rich repeat N-terminal domain |
Function |
The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis. GP-IX may provide for membrane insertion and orientation of GP-Ib. |
Biological Process |
GO:0007596 blood coagulation GO:0007597 blood coagulation, intrinsic pathway GO:0007599 hemostasis GO:0030168 platelet activation GO:0050817 coagulation GO:0050878 regulation of body fluid levels GO:0072376 protein activation cascade GO:0072378 blood coagulation, fibrin clot formation |
Molecular Function | - |
Cellular Component | - |
KEGG |
hsa04512 ECM-receptor interaction hsa04611 Platelet activation hsa04640 Hematopoietic cell lineage |
Reactome |
R-HSA-140877: Formation of Fibrin Clot (Clotting Cascade) R-HSA-430116: GP1b-IX-V activation signalling R-HSA-109582: Hemostasis R-HSA-140837: Intrinsic Pathway of Fibrin Clot Formation R-HSA-75892: Platelet Adhesion to exposed collagen R-HSA-76009: Platelet Aggregation (Plug Formation) R-HSA-76002: Platelet activation, signaling and aggregation |
Summary | |
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Symbol | GP9 |
Name | glycoprotein IX (platelet) |
Aliases | CD42a; GPIX; glycoprotein 9; CD antigen CD42a; GP-IX; Platelet glycoprotein IX |
Chromosomal Location | 3q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between GP9 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | GP9 |
Name | glycoprotein IX (platelet) |
Aliases | CD42a; GPIX; glycoprotein 9; CD antigen CD42a; GP-IX; Platelet glycoprotein IX |
Chromosomal Location | 3q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of GP9 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | GP9 |
Name | glycoprotein IX (platelet) |
Aliases | CD42a; GPIX; glycoprotein 9; CD antigen CD42a; GP-IX; Platelet glycoprotein IX |
Chromosomal Location | 3q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of GP9 in various data sets.
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Points in the above scatter plot represent the mutation difference of GP9 in various data sets.
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Summary | |
---|---|
Symbol | GP9 |
Name | glycoprotein IX (platelet) |
Aliases | CD42a; GPIX; glycoprotein 9; CD antigen CD42a; GP-IX; Platelet glycoprotein IX |
Chromosomal Location | 3q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GP9. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | GP9 |
Name | glycoprotein IX (platelet) |
Aliases | CD42a; GPIX; glycoprotein 9; CD antigen CD42a; GP-IX; Platelet glycoprotein IX |
Chromosomal Location | 3q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GP9. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GP9. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | GP9 |
Name | glycoprotein IX (platelet) |
Aliases | CD42a; GPIX; glycoprotein 9; CD antigen CD42a; GP-IX; Platelet glycoprotein IX |
Chromosomal Location | 3q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GP9. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | GP9 |
Name | glycoprotein IX (platelet) |
Aliases | CD42a; GPIX; glycoprotein 9; CD antigen CD42a; GP-IX; Platelet glycoprotein IX |
Chromosomal Location | 3q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of GP9 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | GP9 |
Name | glycoprotein IX (platelet) |
Aliases | CD42a; GPIX; glycoprotein 9; CD antigen CD42a; GP-IX; Platelet glycoprotein IX |
Chromosomal Location | 3q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between GP9 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | GP9 |
Name | glycoprotein IX (platelet) |
Aliases | CD42a; GPIX; glycoprotein 9; CD antigen CD42a; GP-IX; Platelet glycoprotein IX |
Chromosomal Location | 3q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting GP9 collected from DrugBank database. |
Details on drugs targeting GP9.
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