Browse GPBAR1

Summary
SymbolGPBAR1
NameG protein-coupled bile acid receptor 1
Aliases BG37; TGR5; M-BAR; GPCR19; GPR131; MGC40597; G-protein coupled bile acid receptor BG37; G-protein coupled re ......
Chromosomal Location2q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane Multi-pass membrane protein
Domain PF00001 7 transmembrane receptor (rhodopsin family)
Function

Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids.

> Gene Ontology
 
Biological Process GO:0007043 cell-cell junction assembly
GO:0034329 cell junction assembly
GO:0034330 cell junction organization
GO:0038183 bile acid signaling pathway
GO:0038184 cell surface bile acid receptor signaling pathway
GO:0043297 apical junction assembly
GO:0045216 cell-cell junction organization
GO:0070830 bicellular tight junction assembly
GO:1901888 regulation of cell junction assembly
GO:2000810 regulation of bicellular tight junction assembly
Molecular Function GO:0038181 bile acid receptor activity
GO:0038182 G-protein coupled bile acid receptor activity
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-373076: Class A/1 (Rhodopsin-like receptors)
R-HSA-418555: G alpha (s) signalling events
R-HSA-388396: GPCR downstream signaling
R-HSA-500792: GPCR ligand binding
R-HSA-162582: Signal Transduction
R-HSA-372790: Signaling by GPCR
Summary
SymbolGPBAR1
NameG protein-coupled bile acid receptor 1
Aliases BG37; TGR5; M-BAR; GPCR19; GPR131; MGC40597; G-protein coupled bile acid receptor BG37; G-protein coupled re ......
Chromosomal Location2q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between GPBAR1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolGPBAR1
NameG protein-coupled bile acid receptor 1
Aliases BG37; TGR5; M-BAR; GPCR19; GPR131; MGC40597; G-protein coupled bile acid receptor BG37; G-protein coupled re ......
Chromosomal Location2q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of GPBAR1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolGPBAR1
NameG protein-coupled bile acid receptor 1
Aliases BG37; TGR5; M-BAR; GPCR19; GPR131; MGC40597; G-protein coupled bile acid receptor BG37; G-protein coupled re ......
Chromosomal Location2q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of GPBAR1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.2710.361
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.5520.301
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.0670.884
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.4310.419
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.2330.816
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.6990.645
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.070.902
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.8480.337
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.8920.319
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 481.4670.044
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.9810.355
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.2110.127
> Mutation difference between responders and non-responders
 

There is no record.
Summary
SymbolGPBAR1
NameG protein-coupled bile acid receptor 1
Aliases BG37; TGR5; M-BAR; GPCR19; GPR131; MGC40597; G-protein coupled bile acid receptor BG37; G-protein coupled re ......
Chromosomal Location2q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GPBAR1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolGPBAR1
NameG protein-coupled bile acid receptor 1
Aliases BG37; TGR5; M-BAR; GPCR19; GPR131; MGC40597; G-protein coupled bile acid receptor BG37; G-protein coupled re ......
Chromosomal Location2q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GPBAR1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GPBAR1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolGPBAR1
NameG protein-coupled bile acid receptor 1
Aliases BG37; TGR5; M-BAR; GPCR19; GPR131; MGC40597; G-protein coupled bile acid receptor BG37; G-protein coupled re ......
Chromosomal Location2q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GPBAR1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolGPBAR1
NameG protein-coupled bile acid receptor 1
Aliases BG37; TGR5; M-BAR; GPCR19; GPR131; MGC40597; G-protein coupled bile acid receptor BG37; G-protein coupled re ......
Chromosomal Location2q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of GPBAR1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolGPBAR1
NameG protein-coupled bile acid receptor 1
Aliases BG37; TGR5; M-BAR; GPCR19; GPR131; MGC40597; G-protein coupled bile acid receptor BG37; G-protein coupled re ......
Chromosomal Location2q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between GPBAR1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolGPBAR1
NameG protein-coupled bile acid receptor 1
Aliases BG37; TGR5; M-BAR; GPCR19; GPR131; MGC40597; G-protein coupled bile acid receptor BG37; G-protein coupled re ......
Chromosomal Location2q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting GPBAR1 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting GPBAR1.
ID Name Drug Type Targets #Targets
DB02659Cholic AcidSmall MoleculeADH1C, CES1, COX4I1, COX5A, COX5B, COX6A2, COX6B1, COX6C, COX7A1, ......21
DB03619Deoxycholic AcidSmall MoleculeEFTUD1, GPBAR1, GSTP1, NR1H44
DB06777Chenodeoxycholic acidSmall MoleculeAKR1C2, GPBAR1, NR1H4, NR1I24