Summary | |
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Symbol | GPC3 |
Name | glypican 3 |
Aliases | OCI-5; SGBS; SGBS1; SGB; DGSX; glypican proteoglycan 3; SDYS; GTR2-2; MXR7; heparan sulphate proteoglycan; i ...... |
Chromosomal Location | Xq26 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Lipid-anchor, GPI-anchor Extracellular side ; SUBCELLULAR LOCATION: Secreted glypican-3: Secreted, extracellular space |
Domain |
PF01153 Glypican |
Function |
Cell surface proteoglycan that bears heparan sulfate. Inhibits the dipeptidyl peptidase activity of DPP4. May be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs. May play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. May regulate growth and tumor predisposition. |
Biological Process |
GO:0001503 ossification GO:0001523 retinoid metabolic process GO:0001655 urogenital system development GO:0001656 metanephros development GO:0001657 ureteric bud development GO:0001658 branching involved in ureteric bud morphogenesis GO:0001736 establishment of planar polarity GO:0001738 morphogenesis of a polarized epithelium GO:0001763 morphogenesis of a branching structure GO:0001822 kidney development GO:0001823 mesonephros development GO:0002521 leukocyte differentiation GO:0002573 myeloid leukocyte differentiation GO:0003002 regionalization GO:0006022 aminoglycan metabolic process GO:0006023 aminoglycan biosynthetic process GO:0006024 glycosaminoglycan biosynthetic process GO:0006026 aminoglycan catabolic process GO:0006027 glycosaminoglycan catabolic process GO:0006720 isoprenoid metabolic process GO:0006721 terpenoid metabolic process GO:0007164 establishment of tissue polarity GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007224 smoothened signaling pathway GO:0007389 pattern specification process GO:0007507 heart development GO:0008589 regulation of smoothened signaling pathway GO:0008643 carbohydrate transport GO:0008645 hexose transport GO:0009798 axis specification GO:0009894 regulation of catabolic process GO:0009896 positive regulation of catabolic process GO:0009948 anterior/posterior axis specification GO:0009952 anterior/posterior pattern specification GO:0010171 body morphogenesis GO:0010463 mesenchymal cell proliferation GO:0010466 negative regulation of peptidase activity GO:0010827 regulation of glucose transport GO:0010828 positive regulation of glucose transport GO:0015749 monosaccharide transport GO:0015758 glucose transport GO:0016055 Wnt signaling pathway GO:0016101 diterpenoid metabolic process GO:0030099 myeloid cell differentiation GO:0030100 regulation of endocytosis GO:0030111 regulation of Wnt signaling pathway GO:0030177 positive regulation of Wnt signaling pathway GO:0030178 negative regulation of Wnt signaling pathway GO:0030203 glycosaminoglycan metabolic process GO:0030282 bone mineralization GO:0030316 osteoclast differentiation GO:0030323 respiratory tube development GO:0030324 lung development GO:0030326 embryonic limb morphogenesis GO:0030509 BMP signaling pathway GO:0030510 regulation of BMP signaling pathway GO:0030513 positive regulation of BMP signaling pathway GO:0031214 biomineral tissue development GO:0035107 appendage morphogenesis GO:0035108 limb morphogenesis GO:0035113 embryonic appendage morphogenesis GO:0035116 embryonic hindlimb morphogenesis GO:0035137 hindlimb morphogenesis GO:0035239 tube morphogenesis GO:0035567 non-canonical Wnt signaling pathway GO:0042176 regulation of protein catabolic process GO:0045732 positive regulation of protein catabolic process GO:0045807 positive regulation of endocytosis GO:0045861 negative regulation of proteolysis GO:0045879 negative regulation of smoothened signaling pathway GO:0045880 positive regulation of smoothened signaling pathway GO:0045926 negative regulation of growth GO:0046323 glucose import GO:0046324 regulation of glucose import GO:0046326 positive regulation of glucose import GO:0048736 appendage development GO:0048754 branching morphogenesis of an epithelial tube GO:0050673 epithelial cell proliferation GO:0050678 regulation of epithelial cell proliferation GO:0050680 negative regulation of epithelial cell proliferation GO:0051346 negative regulation of hydrolase activity GO:0052547 regulation of peptidase activity GO:0060070 canonical Wnt signaling pathway GO:0060071 Wnt signaling pathway, planar cell polarity pathway GO:0060173 limb development GO:0060541 respiratory system development GO:0060562 epithelial tube morphogenesis GO:0060627 regulation of vesicle-mediated transport GO:0060675 ureteric bud morphogenesis GO:0060828 regulation of canonical Wnt signaling pathway GO:0060976 coronary vasculature development GO:0060993 kidney morphogenesis GO:0061138 morphogenesis of a branching epithelium GO:0061209 cell proliferation involved in mesonephros development GO:0061326 renal tubule development GO:0061333 renal tubule morphogenesis GO:0071772 response to BMP GO:0071773 cellular response to BMP stimulus GO:0072001 renal system development GO:0072006 nephron development GO:0072009 nephron epithelium development GO:0072028 nephron morphogenesis GO:0072073 kidney epithelium development GO:0072078 nephron tubule morphogenesis GO:0072080 nephron tubule development GO:0072088 nephron epithelium morphogenesis GO:0072111 cell proliferation involved in kidney development GO:0072138 mesenchymal cell proliferation involved in ureteric bud development GO:0072163 mesonephric epithelium development GO:0072164 mesonephric tubule development GO:0072171 mesonephric tubule morphogenesis GO:0072176 nephric duct development GO:0072177 mesonephric duct development GO:0072178 nephric duct morphogenesis GO:0072180 mesonephric duct morphogenesis GO:0072203 cell proliferation involved in metanephros development GO:0090090 negative regulation of canonical Wnt signaling pathway GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway GO:0090175 regulation of establishment of planar polarity GO:0090287 regulation of cellular response to growth factor stimulus GO:0198738 cell-cell signaling by wnt GO:1901136 carbohydrate derivative catabolic process GO:1901565 organonitrogen compound catabolic process GO:1905330 regulation of morphogenesis of an epithelium GO:2000027 regulation of organ morphogenesis GO:2000050 regulation of non-canonical Wnt signaling pathway GO:2000052 positive regulation of non-canonical Wnt signaling pathway GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway |
Molecular Function |
GO:0001948 glycoprotein binding GO:0004857 enzyme inhibitor activity GO:0030414 peptidase inhibitor activity GO:0043394 proteoglycan binding GO:0043395 heparan sulfate proteoglycan binding GO:0060422 peptidyl-dipeptidase inhibitor activity GO:0061134 peptidase regulator activity GO:1901681 sulfur compound binding |
Cellular Component |
GO:0005578 proteinaceous extracellular matrix GO:0005775 vacuolar lumen GO:0005796 Golgi lumen GO:0031225 anchored component of membrane GO:0043202 lysosomal lumen GO:0046658 anchored component of plasma membrane |
KEGG | - |
Reactome |
R-HSA-1971475: A tetrasaccharide linker sequence is required for GAG synthesis R-HSA-1793185: Chondroitin sulfate/dermatan sulfate metabolism R-HSA-4420332: Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-3560801: Defective B3GAT3 causes JDSSDHD R-HSA-3560783: Defective B4GALT7 causes EDS, progeroid type R-HSA-3656253: Defective EXT1 causes exostoses 1, TRPS2 and CHDS R-HSA-3656237: Defective EXT2 causes exostoses 2 R-HSA-1643685: Disease R-HSA-3560782: Diseases associated with glycosaminoglycan metabolism R-HSA-3781865: Diseases of glycosylation R-HSA-1630316: Glycosaminoglycan metabolism R-HSA-2022928: HS-GAG biosynthesis R-HSA-2024096: HS-GAG degradation R-HSA-1638091: Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1430728: Metabolism R-HSA-71387: Metabolism of carbohydrates R-HSA-6806667: Metabolism of fat-soluble vitamins R-HSA-196854: Metabolism of vitamins and cofactors R-HSA-975634: Retinoid metabolism and transport R-HSA-162582: Signal Transduction R-HSA-2187338: Visual phototransduction |
Summary | |
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Symbol | GPC3 |
Name | glypican 3 |
Aliases | OCI-5; SGBS; SGBS1; SGB; DGSX; glypican proteoglycan 3; SDYS; GTR2-2; MXR7; heparan sulphate proteoglycan; i ...... |
Chromosomal Location | Xq26 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between GPC3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between GPC3 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | GPC3 |
Name | glypican 3 |
Aliases | OCI-5; SGBS; SGBS1; SGB; DGSX; glypican proteoglycan 3; SDYS; GTR2-2; MXR7; heparan sulphate proteoglycan; i ...... |
Chromosomal Location | Xq26 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of GPC3 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | GPC3 |
Name | glypican 3 |
Aliases | OCI-5; SGBS; SGBS1; SGB; DGSX; glypican proteoglycan 3; SDYS; GTR2-2; MXR7; heparan sulphate proteoglycan; i ...... |
Chromosomal Location | Xq26 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of GPC3 in various data sets.
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Points in the above scatter plot represent the mutation difference of GPC3 in various data sets.
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Summary | |
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Symbol | GPC3 |
Name | glypican 3 |
Aliases | OCI-5; SGBS; SGBS1; SGB; DGSX; glypican proteoglycan 3; SDYS; GTR2-2; MXR7; heparan sulphate proteoglycan; i ...... |
Chromosomal Location | Xq26 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GPC3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | GPC3 |
Name | glypican 3 |
Aliases | OCI-5; SGBS; SGBS1; SGB; DGSX; glypican proteoglycan 3; SDYS; GTR2-2; MXR7; heparan sulphate proteoglycan; i ...... |
Chromosomal Location | Xq26 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GPC3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GPC3. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | GPC3 |
Name | glypican 3 |
Aliases | OCI-5; SGBS; SGBS1; SGB; DGSX; glypican proteoglycan 3; SDYS; GTR2-2; MXR7; heparan sulphate proteoglycan; i ...... |
Chromosomal Location | Xq26 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GPC3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | GPC3 |
Name | glypican 3 |
Aliases | OCI-5; SGBS; SGBS1; SGB; DGSX; glypican proteoglycan 3; SDYS; GTR2-2; MXR7; heparan sulphate proteoglycan; i ...... |
Chromosomal Location | Xq26 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of GPC3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | GPC3 |
Name | glypican 3 |
Aliases | OCI-5; SGBS; SGBS1; SGB; DGSX; glypican proteoglycan 3; SDYS; GTR2-2; MXR7; heparan sulphate proteoglycan; i ...... |
Chromosomal Location | Xq26 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between GPC3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | GPC3 |
Name | glypican 3 |
Aliases | OCI-5; SGBS; SGBS1; SGB; DGSX; glypican proteoglycan 3; SDYS; GTR2-2; MXR7; heparan sulphate proteoglycan; i ...... |
Chromosomal Location | Xq26 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting GPC3 collected from DrugBank database. |
There is no record. |