Summary | |
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Symbol | GPI |
Name | glucose-6-phosphate isomerase |
Aliases | AMF; glucose phosphate isomerase; PHI; SA-36; SA36; autocrine motility factor; hexose monophosphate isomeras ...... |
Chromosomal Location | 19q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Secreted |
Domain |
PF00342 Phosphoglucose isomerase |
Function |
Besides it's role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons. |
Biological Process |
GO:0001525 angiogenesis GO:0001701 in utero embryonic development GO:0001704 formation of primary germ layer GO:0001707 mesoderm formation GO:0002262 myeloid cell homeostasis GO:0005996 monosaccharide metabolic process GO:0006006 glucose metabolic process GO:0006007 glucose catabolic process GO:0006081 cellular aldehyde metabolic process GO:0006090 pyruvate metabolic process GO:0006091 generation of precursor metabolites and energy GO:0006094 gluconeogenesis GO:0006096 glycolytic process GO:0006165 nucleoside diphosphate phosphorylation GO:0006732 coenzyme metabolic process GO:0006733 oxidoreduction coenzyme metabolic process GO:0006734 NADH metabolic process GO:0006735 NADH regeneration GO:0006757 ATP generation from ADP GO:0006959 humoral immune response GO:0007369 gastrulation GO:0007498 mesoderm development GO:0007599 hemostasis GO:0007611 learning or memory GO:0009116 nucleoside metabolic process GO:0009119 ribonucleoside metabolic process GO:0009123 nucleoside monophosphate metabolic process GO:0009126 purine nucleoside monophosphate metabolic process GO:0009132 nucleoside diphosphate metabolic process GO:0009135 purine nucleoside diphosphate metabolic process GO:0009141 nucleoside triphosphate metabolic process GO:0009144 purine nucleoside triphosphate metabolic process GO:0009150 purine ribonucleotide metabolic process GO:0009161 ribonucleoside monophosphate metabolic process GO:0009167 purine ribonucleoside monophosphate metabolic process GO:0009179 purine ribonucleoside diphosphate metabolic process GO:0009185 ribonucleoside diphosphate metabolic process GO:0009199 ribonucleoside triphosphate metabolic process GO:0009205 purine ribonucleoside triphosphate metabolic process GO:0009438 methylglyoxal metabolic process GO:0009612 response to mechanical stimulus GO:0010035 response to inorganic substance GO:0010038 response to metal ion GO:0010466 negative regulation of peptidase activity GO:0010951 negative regulation of endopeptidase activity GO:0014072 response to isoquinoline alkaloid GO:0016051 carbohydrate biosynthetic process GO:0016052 carbohydrate catabolic process GO:0019242 methylglyoxal biosynthetic process GO:0019318 hexose metabolic process GO:0019319 hexose biosynthetic process GO:0019320 hexose catabolic process GO:0019362 pyridine nucleotide metabolic process GO:0019674 NAD metabolic process GO:0032355 response to estradiol GO:0032570 response to progesterone GO:0033500 carbohydrate homeostasis GO:0033574 response to testosterone GO:0034101 erythrocyte homeostasis GO:0035902 response to immobilization stress GO:0035994 response to muscle stretch GO:0042180 cellular ketone metabolic process GO:0042181 ketone biosynthetic process GO:0042278 purine nucleoside metabolic process GO:0042593 glucose homeostasis GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043278 response to morphine GO:0043279 response to alkaloid GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043523 regulation of neuron apoptotic process GO:0043524 negative regulation of neuron apoptotic process GO:0044282 small molecule catabolic process GO:0044283 small molecule biosynthetic process GO:0044708 single-organism behavior GO:0044723 single-organism carbohydrate metabolic process GO:0044724 single-organism carbohydrate catabolic process GO:0045861 negative regulation of proteolysis GO:0046031 ADP metabolic process GO:0046034 ATP metabolic process GO:0046128 purine ribonucleoside metabolic process GO:0046184 aldehyde biosynthetic process GO:0046185 aldehyde catabolic process GO:0046364 monosaccharide biosynthetic process GO:0046365 monosaccharide catabolic process GO:0046496 nicotinamide nucleotide metabolic process GO:0046686 response to cadmium ion GO:0046939 nucleotide phosphorylation GO:0048332 mesoderm morphogenesis GO:0048514 blood vessel morphogenesis GO:0048545 response to steroid hormone GO:0048872 homeostasis of number of cells GO:0050878 regulation of body fluid levels GO:0050890 cognition GO:0051156 glucose 6-phosphate metabolic process GO:0051186 cofactor metabolic process GO:0051346 negative regulation of hydrolase activity GO:0051402 neuron apoptotic process GO:0052547 regulation of peptidase activity GO:0052548 regulation of endopeptidase activity GO:0061615 glycolytic process through fructose-6-phosphate GO:0061620 glycolytic process through glucose-6-phosphate GO:0061621 canonical glycolysis GO:0061718 glucose catabolic process to pyruvate GO:0070997 neuron death GO:0072524 pyridine-containing compound metabolic process GO:1901214 regulation of neuron death GO:1901215 negative regulation of neuron death GO:1901654 response to ketone GO:1901657 glycosyl compound metabolic process GO:2000116 regulation of cysteine-type endopeptidase activity GO:2000117 negative regulation of cysteine-type endopeptidase activity |
Molecular Function |
GO:0004347 glucose-6-phosphate isomerase activity GO:0005125 cytokine activity GO:0008083 growth factor activity GO:0016853 isomerase activity GO:0016860 intramolecular oxidoreductase activity GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses GO:0016866 intramolecular transferase activity GO:0030246 carbohydrate binding GO:0031625 ubiquitin protein ligase binding GO:0044389 ubiquitin-like protein ligase binding GO:0048029 monosaccharide binding |
Cellular Component |
GO:0005929 cilium GO:0031253 cell projection membrane GO:0043209 myelin sheath GO:0044441 ciliary part GO:0060170 ciliary membrane |
KEGG |
hsa00010 Glycolysis / Gluconeogenesis hsa00030 Pentose phosphate pathway hsa00500 Starch and sucrose metabolism hsa00520 Amino sugar and nucleotide sugar metabolism hsa01100 Metabolic pathways hsa01200 Carbon metabolism |
Reactome |
R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-70263: Gluconeogenesis R-HSA-70326: Glucose metabolism R-HSA-70171: Glycolysis R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-1430728: Metabolism R-HSA-71387: Metabolism of carbohydrates R-HSA-6798695: Neutrophil degranulation R-HSA-5628897: TP53 Regulates Metabolic Genes R-HSA-3700989: Transcriptional Regulation by TP53 |
Summary | |
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Symbol | GPI |
Name | glucose-6-phosphate isomerase |
Aliases | AMF; glucose phosphate isomerase; PHI; SA-36; SA36; autocrine motility factor; hexose monophosphate isomeras ...... |
Chromosomal Location | 19q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between GPI and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | GPI |
Name | glucose-6-phosphate isomerase |
Aliases | AMF; glucose phosphate isomerase; PHI; SA-36; SA36; autocrine motility factor; hexose monophosphate isomeras ...... |
Chromosomal Location | 19q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of GPI in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | GPI |
Name | glucose-6-phosphate isomerase |
Aliases | AMF; glucose phosphate isomerase; PHI; SA-36; SA36; autocrine motility factor; hexose monophosphate isomeras ...... |
Chromosomal Location | 19q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of GPI in various data sets.
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Points in the above scatter plot represent the mutation difference of GPI in various data sets.
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Summary | |
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Symbol | GPI |
Name | glucose-6-phosphate isomerase |
Aliases | AMF; glucose phosphate isomerase; PHI; SA-36; SA36; autocrine motility factor; hexose monophosphate isomeras ...... |
Chromosomal Location | 19q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GPI. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | GPI |
Name | glucose-6-phosphate isomerase |
Aliases | AMF; glucose phosphate isomerase; PHI; SA-36; SA36; autocrine motility factor; hexose monophosphate isomeras ...... |
Chromosomal Location | 19q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GPI. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GPI. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | GPI |
Name | glucose-6-phosphate isomerase |
Aliases | AMF; glucose phosphate isomerase; PHI; SA-36; SA36; autocrine motility factor; hexose monophosphate isomeras ...... |
Chromosomal Location | 19q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GPI. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | GPI |
Name | glucose-6-phosphate isomerase |
Aliases | AMF; glucose phosphate isomerase; PHI; SA-36; SA36; autocrine motility factor; hexose monophosphate isomeras ...... |
Chromosomal Location | 19q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of GPI expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | GPI |
Name | glucose-6-phosphate isomerase |
Aliases | AMF; glucose phosphate isomerase; PHI; SA-36; SA36; autocrine motility factor; hexose monophosphate isomeras ...... |
Chromosomal Location | 19q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between GPI and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | GPI |
Name | glucose-6-phosphate isomerase |
Aliases | AMF; glucose phosphate isomerase; PHI; SA-36; SA36; autocrine motility factor; hexose monophosphate isomeras ...... |
Chromosomal Location | 19q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting GPI collected from DrugBank database. |
Details on drugs targeting GPI.
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