Browse GPIHBP1

Summary
SymbolGPIHBP1
Nameglycosylphosphatidylinositol anchored high density lipoprotein binding protein 1
Aliases LOC338328; GPI-HBP1; endothelial cell LPL transporter; GPI anchored high density lipoprotein binding protein ......
Chromosomal Location8q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Apical cell membrane Lipid-anchor, GPI-anchor Basolateral cell membrane Lipid-anchor, GPI-anchor Cell membrane Peripheral membrane protein Extracellular side
Domain PF00021 u-PAR/Ly-6 domain
Function

Plays a key role in the lipolytic processing of chylomicrons. Required for the transport of lipoprotein lipase LPL into the capillary lumen (By similarity).

> Gene Ontology
 
Biological Process GO:0006869 lipid transport
GO:0010876 lipid localization
GO:0010984 regulation of lipoprotein particle clearance
GO:0010986 positive regulation of lipoprotein particle clearance
GO:0017038 protein import
GO:0031647 regulation of protein stability
GO:0034381 plasma lipoprotein particle clearance
GO:0034382 chylomicron remnant clearance
GO:0034394 protein localization to cell surface
GO:0042632 cholesterol homeostasis
GO:0045056 transcytosis
GO:0050821 protein stabilization
GO:0051004 regulation of lipoprotein lipase activity
GO:0051006 positive regulation of lipoprotein lipase activity
GO:0055088 lipid homeostasis
GO:0055090 acylglycerol homeostasis
GO:0055092 sterol homeostasis
GO:0060191 regulation of lipase activity
GO:0060193 positive regulation of lipase activity
GO:0061365 positive regulation of triglyceride lipase activity
GO:0070328 triglyceride homeostasis
GO:0071503 response to heparin
GO:0071806 protein transmembrane transport
GO:0071830 triglyceride-rich lipoprotein particle clearance
GO:0090320 regulation of chylomicron remnant clearance
GO:0090321 positive regulation of chylomicron remnant clearance
GO:0097006 regulation of plasma lipoprotein particle levels
Molecular Function GO:0008035 high-density lipoprotein particle binding
GO:0008320 protein transmembrane transporter activity
GO:0008565 protein transporter activity
GO:0022884 macromolecule transmembrane transporter activity
GO:0035473 lipase binding
GO:0035478 chylomicron binding
GO:0071813 lipoprotein particle binding
GO:0071814 protein-lipid complex binding
Cellular Component GO:0009897 external side of plasma membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0031225 anchored component of membrane
GO:0031233 intrinsic component of external side of plasma membrane
GO:0031362 anchored component of external side of plasma membrane
GO:0032994 protein-lipid complex
GO:0034358 plasma lipoprotein particle
GO:0034364 high-density lipoprotein particle
GO:0045177 apical part of cell
GO:0046658 anchored component of plasma membrane
GO:0098552 side of membrane
GO:1990777 lipoprotein particle
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-174800: Chylomicron-mediated lipid transport
R-HSA-73923: Lipid digestion, mobilization, and transport
R-HSA-174824: Lipoprotein metabolism
R-HSA-1430728: Metabolism
R-HSA-6806667: Metabolism of fat-soluble vitamins
R-HSA-556833: Metabolism of lipids and lipoproteins
R-HSA-392499: Metabolism of proteins
R-HSA-196854: Metabolism of vitamins and cofactors
R-HSA-163125: Post-translational modification
R-HSA-597592: Post-translational protein modification
R-HSA-975634: Retinoid metabolism and transport
R-HSA-162582: Signal Transduction
R-HSA-2187338: Visual phototransduction
Summary
SymbolGPIHBP1
Nameglycosylphosphatidylinositol anchored high density lipoprotein binding protein 1
Aliases LOC338328; GPI-HBP1; endothelial cell LPL transporter; GPI anchored high density lipoprotein binding protein ......
Chromosomal Location8q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between GPIHBP1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolGPIHBP1
Nameglycosylphosphatidylinositol anchored high density lipoprotein binding protein 1
Aliases LOC338328; GPI-HBP1; endothelial cell LPL transporter; GPI anchored high density lipoprotein binding protein ......
Chromosomal Location8q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of GPIHBP1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolGPIHBP1
Nameglycosylphosphatidylinositol anchored high density lipoprotein binding protein 1
Aliases LOC338328; GPI-HBP1; endothelial cell LPL transporter; GPI anchored high density lipoprotein binding protein ......
Chromosomal Location8q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of GPIHBP1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.5430.117
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.4410.485
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.6070.205
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.3790.599
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.40.72
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 471.3730.307
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.2270.702
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.0190.982
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.560.545
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 4801
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 2801
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.6770.00161
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of GPIHBP1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27730001
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211705.9-5.90.447
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)86016.7-16.70.429
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolGPIHBP1
Nameglycosylphosphatidylinositol anchored high density lipoprotein binding protein 1
Aliases LOC338328; GPI-HBP1; endothelial cell LPL transporter; GPI anchored high density lipoprotein binding protein ......
Chromosomal Location8q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GPIHBP1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolGPIHBP1
Nameglycosylphosphatidylinositol anchored high density lipoprotein binding protein 1
Aliases LOC338328; GPI-HBP1; endothelial cell LPL transporter; GPI anchored high density lipoprotein binding protein ......
Chromosomal Location8q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GPIHBP1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GPIHBP1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolGPIHBP1
Nameglycosylphosphatidylinositol anchored high density lipoprotein binding protein 1
Aliases LOC338328; GPI-HBP1; endothelial cell LPL transporter; GPI anchored high density lipoprotein binding protein ......
Chromosomal Location8q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GPIHBP1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolGPIHBP1
Nameglycosylphosphatidylinositol anchored high density lipoprotein binding protein 1
Aliases LOC338328; GPI-HBP1; endothelial cell LPL transporter; GPI anchored high density lipoprotein binding protein ......
Chromosomal Location8q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of GPIHBP1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolGPIHBP1
Nameglycosylphosphatidylinositol anchored high density lipoprotein binding protein 1
Aliases LOC338328; GPI-HBP1; endothelial cell LPL transporter; GPI anchored high density lipoprotein binding protein ......
Chromosomal Location8q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between GPIHBP1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolGPIHBP1
Nameglycosylphosphatidylinositol anchored high density lipoprotein binding protein 1
Aliases LOC338328; GPI-HBP1; endothelial cell LPL transporter; GPI anchored high density lipoprotein binding protein ......
Chromosomal Location8q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting GPIHBP1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.