Summary | |
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Symbol | GPLD1 |
Name | glycosylphosphatidylinositol specific phospholipase D1 |
Aliases | GPIPLD; GPIPLDM; PIGPLD; PIGPLD1; GPI-PLD; GPI-specific phospholipase D; PI-G PLD; glycoprotein phospholipas ...... |
Chromosomal Location | 6p22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted. |
Domain |
PF01839 FG-GAP repeat PF00882 Zinc dependent phospholipase C |
Function |
This protein hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans (GPI-anchor) thus releasing these proteins from the membrane. |
Biological Process |
GO:0001501 skeletal system development GO:0001503 ossification GO:0001525 angiogenesis GO:0001667 ameboidal-type cell migration GO:0001678 cellular glucose homeostasis GO:0002040 sprouting angiogenesis GO:0002042 cell migration involved in sprouting angiogenesis GO:0002062 chondrocyte differentiation GO:0002429 immune response-activating cell surface receptor signaling pathway GO:0002430 complement receptor mediated signaling pathway GO:0002757 immune response-activating signal transduction GO:0002764 immune response-regulating signaling pathway GO:0002768 immune response-regulating cell surface receptor signaling pathway GO:0002790 peptide secretion GO:0002791 regulation of peptide secretion GO:0002793 positive regulation of peptide secretion GO:0005996 monosaccharide metabolic process GO:0006006 glucose metabolic process GO:0006109 regulation of carbohydrate metabolic process GO:0006505 GPI anchor metabolic process GO:0006507 GPI anchor release GO:0006509 membrane protein ectodomain proteolysis GO:0006638 neutral lipid metabolic process GO:0006639 acylglycerol metabolic process GO:0006641 triglyceride metabolic process GO:0006643 membrane lipid metabolic process GO:0006644 phospholipid metabolic process GO:0006650 glycerophospholipid metabolic process GO:0006664 glycolipid metabolic process GO:0008286 insulin receptor signaling pathway GO:0009268 response to pH GO:0009306 protein secretion GO:0009743 response to carbohydrate GO:0009746 response to hexose GO:0009749 response to glucose GO:0009894 regulation of catabolic process GO:0009895 negative regulation of catabolic process GO:0009896 positive regulation of catabolic process GO:0009914 hormone transport GO:0010035 response to inorganic substance GO:0010038 response to metal ion GO:0010594 regulation of endothelial cell migration GO:0010595 positive regulation of endothelial cell migration GO:0010631 epithelial cell migration GO:0010632 regulation of epithelial cell migration GO:0010634 positive regulation of epithelial cell migration GO:0010675 regulation of cellular carbohydrate metabolic process GO:0010676 positive regulation of cellular carbohydrate metabolic process GO:0010692 regulation of alkaline phosphatase activity GO:0010694 positive regulation of alkaline phosphatase activity GO:0010817 regulation of hormone levels GO:0010866 regulation of triglyceride biosynthetic process GO:0010867 positive regulation of triglyceride biosynthetic process GO:0010896 regulation of triglyceride catabolic process GO:0010897 negative regulation of triglyceride catabolic process GO:0010906 regulation of glucose metabolic process GO:0010907 positive regulation of glucose metabolic process GO:0010921 regulation of phosphatase activity GO:0010922 positive regulation of phosphatase activity GO:0010982 regulation of high-density lipoprotein particle clearance GO:0010983 positive regulation of high-density lipoprotein particle clearance GO:0010984 regulation of lipoprotein particle clearance GO:0010986 positive regulation of lipoprotein particle clearance GO:0015833 peptide transport GO:0016042 lipid catabolic process GO:0016311 dephosphorylation GO:0019216 regulation of lipid metabolic process GO:0019318 hexose metabolic process GO:0019432 triglyceride biosynthetic process GO:0019433 triglyceride catabolic process GO:0019835 cytolysis GO:0023061 signal release GO:0030072 peptide hormone secretion GO:0030073 insulin secretion GO:0030335 positive regulation of cell migration GO:0031329 regulation of cellular catabolic process GO:0031330 negative regulation of cellular catabolic process GO:0031331 positive regulation of cellular catabolic process GO:0032024 positive regulation of insulin secretion GO:0032844 regulation of homeostatic process GO:0032846 positive regulation of homeostatic process GO:0032868 response to insulin GO:0032869 cellular response to insulin stimulus GO:0033500 carbohydrate homeostasis GO:0033619 membrane protein proteolysis GO:0034014 response to triglyceride GO:0034284 response to monosaccharide GO:0034381 plasma lipoprotein particle clearance GO:0034384 high-density lipoprotein particle clearance GO:0035303 regulation of dephosphorylation GO:0035306 positive regulation of dephosphorylation GO:0035690 cellular response to drug GO:0035701 hematopoietic stem cell migration GO:0035773 insulin secretion involved in cellular response to glucose stimulus GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0036314 response to sterol GO:0036315 cellular response to sterol GO:0040017 positive regulation of locomotion GO:0042176 regulation of protein catabolic process GO:0042268 regulation of cytolysis GO:0042493 response to drug GO:0042593 glucose homeostasis GO:0042886 amide transport GO:0043434 response to peptide hormone GO:0043534 blood vessel endothelial cell migration GO:0043542 endothelial cell migration GO:0044242 cellular lipid catabolic process GO:0044262 cellular carbohydrate metabolic process GO:0044723 single-organism carbohydrate metabolic process GO:0045017 glycerolipid biosynthetic process GO:0045732 positive regulation of protein catabolic process GO:0045833 negative regulation of lipid metabolic process GO:0045834 positive regulation of lipid metabolic process GO:0045862 positive regulation of proteolysis GO:0045913 positive regulation of carbohydrate metabolic process GO:0045919 positive regulation of cytolysis GO:0046460 neutral lipid biosynthetic process GO:0046461 neutral lipid catabolic process GO:0046463 acylglycerol biosynthetic process GO:0046464 acylglycerol catabolic process GO:0046470 phosphatidylcholine metabolic process GO:0046486 glycerolipid metabolic process GO:0046488 phosphatidylinositol metabolic process GO:0046503 glycerolipid catabolic process GO:0046879 hormone secretion GO:0046883 regulation of hormone secretion GO:0046887 positive regulation of hormone secretion GO:0046889 positive regulation of lipid biosynthetic process GO:0046890 regulation of lipid biosynthetic process GO:0048514 blood vessel morphogenesis GO:0050708 regulation of protein secretion GO:0050714 positive regulation of protein secretion GO:0050796 regulation of insulin secretion GO:0050994 regulation of lipid catabolic process GO:0050995 negative regulation of lipid catabolic process GO:0051043 regulation of membrane protein ectodomain proteolysis GO:0051044 positive regulation of membrane protein ectodomain proteolysis GO:0051047 positive regulation of secretion GO:0051216 cartilage development GO:0051222 positive regulation of protein transport GO:0051272 positive regulation of cellular component movement GO:0051592 response to calcium ion GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus GO:0061448 connective tissue development GO:0070633 transepithelial transport GO:0070723 response to cholesterol GO:0071214 cellular response to abiotic stimulus GO:0071241 cellular response to inorganic substance GO:0071248 cellular response to metal ion GO:0071277 cellular response to calcium ion GO:0071322 cellular response to carbohydrate stimulus GO:0071326 cellular response to monosaccharide stimulus GO:0071331 cellular response to hexose stimulus GO:0071333 cellular response to glucose stimulus GO:0071375 cellular response to peptide hormone stimulus GO:0071396 cellular response to lipid GO:0071397 cellular response to cholesterol GO:0071401 cellular response to triglyceride GO:0071407 cellular response to organic cyclic compound GO:0071417 cellular response to organonitrogen compound GO:0071467 cellular response to pH GO:0090087 regulation of peptide transport GO:0090130 tissue migration GO:0090132 epithelium migration GO:0090207 regulation of triglyceride metabolic process GO:0090208 positive regulation of triglyceride metabolic process GO:0090209 negative regulation of triglyceride metabolic process GO:0090276 regulation of peptide hormone secretion GO:0090277 positive regulation of peptide hormone secretion GO:0097006 regulation of plasma lipoprotein particle levels GO:0097164 ammonium ion metabolic process GO:0097241 hematopoietic stem cell migration to bone marrow GO:0097305 response to alcohol GO:0097306 cellular response to alcohol GO:1900076 regulation of cellular response to insulin stimulus GO:1901652 response to peptide GO:1901653 cellular response to peptide GO:1903509 liposaccharide metabolic process GO:1903532 positive regulation of secretion by cell GO:1904951 positive regulation of establishment of protein localization GO:2000147 positive regulation of cell motility |
Molecular Function |
GO:0004620 phospholipase activity GO:0004621 glycosylphosphatidylinositol phospholipase D activity GO:0004630 phospholipase D activity GO:0008081 phosphoric diester hydrolase activity GO:0016247 channel regulator activity GO:0016298 lipase activity GO:0017080 sodium channel regulator activity GO:0042578 phosphoric ester hydrolase activity |
Cellular Component |
GO:0005578 proteinaceous extracellular matrix GO:0005765 lysosomal membrane GO:0098852 lytic vacuole membrane |
KEGG |
hsa00563 Glycosylphosphatidylinositol(GPI)-anchor biosynthesis |
Reactome |
R-HSA-392499: Metabolism of proteins R-HSA-163125: Post-translational modification R-HSA-597592: Post-translational protein modification |
Summary | |
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Symbol | GPLD1 |
Name | glycosylphosphatidylinositol specific phospholipase D1 |
Aliases | GPIPLD; GPIPLDM; PIGPLD; PIGPLD1; GPI-PLD; GPI-specific phospholipase D; PI-G PLD; glycoprotein phospholipas ...... |
Chromosomal Location | 6p22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between GPLD1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | GPLD1 |
Name | glycosylphosphatidylinositol specific phospholipase D1 |
Aliases | GPIPLD; GPIPLDM; PIGPLD; PIGPLD1; GPI-PLD; GPI-specific phospholipase D; PI-G PLD; glycoprotein phospholipas ...... |
Chromosomal Location | 6p22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of GPLD1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | GPLD1 |
Name | glycosylphosphatidylinositol specific phospholipase D1 |
Aliases | GPIPLD; GPIPLDM; PIGPLD; PIGPLD1; GPI-PLD; GPI-specific phospholipase D; PI-G PLD; glycoprotein phospholipas ...... |
Chromosomal Location | 6p22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of GPLD1 in various data sets.
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Points in the above scatter plot represent the mutation difference of GPLD1 in various data sets.
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Summary | |
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Symbol | GPLD1 |
Name | glycosylphosphatidylinositol specific phospholipase D1 |
Aliases | GPIPLD; GPIPLDM; PIGPLD; PIGPLD1; GPI-PLD; GPI-specific phospholipase D; PI-G PLD; glycoprotein phospholipas ...... |
Chromosomal Location | 6p22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GPLD1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | GPLD1 |
Name | glycosylphosphatidylinositol specific phospholipase D1 |
Aliases | GPIPLD; GPIPLDM; PIGPLD; PIGPLD1; GPI-PLD; GPI-specific phospholipase D; PI-G PLD; glycoprotein phospholipas ...... |
Chromosomal Location | 6p22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GPLD1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GPLD1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | GPLD1 |
Name | glycosylphosphatidylinositol specific phospholipase D1 |
Aliases | GPIPLD; GPIPLDM; PIGPLD; PIGPLD1; GPI-PLD; GPI-specific phospholipase D; PI-G PLD; glycoprotein phospholipas ...... |
Chromosomal Location | 6p22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GPLD1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | GPLD1 |
Name | glycosylphosphatidylinositol specific phospholipase D1 |
Aliases | GPIPLD; GPIPLDM; PIGPLD; PIGPLD1; GPI-PLD; GPI-specific phospholipase D; PI-G PLD; glycoprotein phospholipas ...... |
Chromosomal Location | 6p22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of GPLD1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | GPLD1 |
Name | glycosylphosphatidylinositol specific phospholipase D1 |
Aliases | GPIPLD; GPIPLDM; PIGPLD; PIGPLD1; GPI-PLD; GPI-specific phospholipase D; PI-G PLD; glycoprotein phospholipas ...... |
Chromosomal Location | 6p22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between GPLD1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | GPLD1 |
Name | glycosylphosphatidylinositol specific phospholipase D1 |
Aliases | GPIPLD; GPIPLDM; PIGPLD; PIGPLD1; GPI-PLD; GPI-specific phospholipase D; PI-G PLD; glycoprotein phospholipas ...... |
Chromosomal Location | 6p22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting GPLD1 collected from DrugBank database. |
There is no record. |